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Senior Director Protein Engineering Jobs (NOW HIRING)

Systimmune

Director, Protein Engineering

Redmond, WA · On-site

$180K - $240K/yr

SystImmune is seeking a Director of Protein Engineering to lead the FUSE team. This is a hands-on ... senior leadership and external partners. Preferred Qualifications * Experience in oncology ...

Jj

Director, Protein Sciences

Spring House, PA · On-site

The Director, Protein Sciences will integrate target biology insight, computational protein design, cell engineering, and experimental protein sciences to drive the generation of high-quality ...

Jj

Director, Protein Sciences

Cambridge, MA · On-site

The Director, Protein Sciences will integrate target biology insight, computational protein design, cell engineering, and experimental protein sciences to drive the generation of high-quality ...

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Senior Director Protein Engineering information

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$35K

$120.8K

$192K

How much do senior director protein engineering jobs pay per year?

As of Sep 7, 2026, the average yearly pay for senior director protein engineering in the United States is $120,836.00, according to ZipRecruiter salary data. Most workers in this role earn between $75,000.00 and $156,000.00 per year, depending on experience, location, and employer.

What is the difference between Senior Director Protein Engineering vs Principal Scientist Protein Engineering?

AspectSenior Director Protein EngineeringPrincipal Scientist Protein Engineering
CredentialsAdvanced degree (PhD/MSc), extensive industry experience, leadership skillsPhD preferred, strong research background, technical expertise
Work EnvironmentLeadership role overseeing teams, strategic planning, cross-functional collaborationResearch-focused, hands-on scientific work, experimental design
Employer & Industry UsageBiotech, pharma companies, large R&D organizationsResearch institutes, biotech firms, pharma companies
Search & Comparison IntentUnderstanding leadership roles in protein engineeringTechnical expertise and research focus in protein engineering

The Senior Director Protein Engineering typically holds a leadership position, managing teams and setting strategic direction, while the Principal Scientist Protein Engineering is more research-focused, emphasizing technical expertise and experimental work. Both roles require advanced degrees and industry experience, but differ mainly in scope and responsibilities.

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Senior Director Protein Engineering jobs near you
Infographic showing various Senior Director Protein Engineering job openings in the United States as of August 2026, with employment types broken down into 92% Full Time, 4% Part Time, 3% Contract, and 1% Nights. Highlights an 86% Physical, 4% Hybrid, and 10% Remote job distribution, with an average salary of $120,836 per year, or $58.1 per hour.

Senior Scientific Director, Protein Engineering

Scorpion Therapeutics

San Diego, CA • On-site

$250 - $350/hr

Other

Posted 8 days ago

Job description

About The Role

Senior Scientific Director, Protein Engineering provides scientific and strategic leadership for Neurocrine’s protein engineering and biologics discovery capabilities. Leads a team of protein engineers and expands technical expertise/platforms to enable next-generation biotherapeutics.

Your ContributionsScientific Leadership
  • Lead and provide strategic direction for the Protein Engineering function; set scientific priorities for the biologics portfolio
  • Guide programs from target assessment through lead generation, optimization, candidate selection, and transition into development
  • Drive innovation in antibody and protein engineering technologies
  • Evaluate and implement emerging technologies, platforms, and computational approaches
Organizational Leadership
  • Lead, mentor, and develop protein engineering talent; recruit additional scientific talent
  • Foster a collaborative, innovative, inclusive scientific culture
  • Build capabilities via investment in new technologies, workflows, and expertise
  • Establish/maintain collaborations with CROs, academics, and technology providers
Drug Discovery & Cross-Functional Collaboration
  • Partner cross-functionally to advance biologics programs through discovery and IND-enabling studies
  • Lead candidate selection, developability assessment, and optimization strategies
  • Provide data-driven recommendations for governance and portfolio decisions
  • Ensure protein engineering work aligns with timelines, quality standards, and objectives
RequirementsRequired
  • PhD (10+ years) OR Master’s (20+ years) OR Bachelor’s (22+ years) in relevant discipline
  • Demonstrated scientific leadership advancing antibody/protein therapeutics from discovery through IND-enabling development
  • Extensive expertise in protein/antibody engineering and structure-function relationships
  • Expertise in protein conjugation, multispecifics, ADCs, or other next-gen biologics
  • Experience leading high-performing scientific teams and building protein engineering capabilities
  • Deep knowledge of biologics discovery workflows (molecular design, lead optimization, developability, candidate selection)
  • Strong construct design, recombinant expression (mammalian/microbial), purification, biochemical/biophysical characterization
  • Knowledge of antibody discovery technologies (e.g., display platforms, affinity maturation, engineered scaffolds)
  • Experience managing CRO/external collaborations; strong publication/patent record
  • Excellent scientific communication; ability to translate strategy into executable plans
Preferred
  • Experience developing therapeutic antibodies/biologics in neuroscience, endocrinology, immunology, or inflammation
  • Computational protein design, ML-enabled engineering, or AI-assisted design
  • High-throughput screening, protein display, developability assessment
  • Familiarity with LC-MS characterization
  • Knowledge of regulatory expectations for IND submission
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