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Senior Director Clinical Operations information

See Indiana salary details

$57.1K

$138.9K

$268.8K

How much do senior director clinical operations jobs pay per year?

As of Aug 11, 2026, the average yearly pay for senior director clinical operations in Indiana is $138,899.00, according to ZipRecruiter salary data. Most workers in this role earn between $97,100.00 and $165,100.00 per year, depending on experience, location, and employer.

What are the primary responsibilities of a senior director clinical operations?

A Senior Director Clinical Operations typically oversees multiple clinical trial programs, ensuring they run efficiently, meet quality and compliance standards, and stay within budget. They provide leadership and direction to clinical operations teams, collaborate closely with cross-functional departments like regulatory affairs, data management, and medical affairs, and engage with external vendors or partners as needed. Regular responsibilities also include monitoring project progress, addressing operational challenges, managing timelines, and developing process improvements. This role is highly collaborative and requires the ability to make strategic decisions that impact the success of trial outcomes and organizational goals.

What is a senior director clinical operations?

A Senior Director of Clinical Operations oversees the planning, execution, and management of clinical trials to ensure compliance with regulatory guidelines and company objectives. They lead cross-functional teams, manage budgets, and develop strategies to optimize trial efficiency. This role requires strong leadership, strategic planning, and operational expertise to drive successful trial outcomes. They also collaborate with stakeholders, monitor trial progress, and implement process improvements.

What are the key skills and qualifications needed to thrive in the senior director clinical operations position?

To thrive as a Senior Director Clinical Operations, you need extensive experience in clinical research or healthcare management, a strong understanding of regulatory requirements (such as GCP and ICH), and typically hold an advanced degree in life sciences or a related field. Familiarity with clinical trial management systems (CTMS), project management software, and regulatory submission tools is essential, and a certification such as PMP or ACRP can be advantageous. Outstanding leadership, strategic thinking, and communication skills help you effectively manage teams and build relationships with stakeholders. These competencies ensure operational excellence, compliant trial execution, and the ability to lead large, complex projects to successful outcomes.

What are popular job titles related to Senior Director Clinical Operations jobs in Indiana? For Senior Director Clinical Operations jobs in Indiana, the most frequently searched job titles are:
What job categories do people searching Senior Director Clinical Operations jobs in Indiana look for? The top searched job categories for Senior Director Clinical Operations jobs in Indiana are:
What cities in Indiana are hiring for Senior Director Clinical Operations jobs? Cities in Indiana with the most Senior Director Clinical Operations job openings:
Senior Director Clinical Operations jobs near you
Infographic showing various Senior Director Clinical Operations job openings in Indiana as of August 2026, with employment types broken down into 84% Full Time, 13% Part Time, 1% Temporary, and 2% Contract. Highlights an 94% Physical, 2% Hybrid, and 4% Remote job distribution, with an average salary of $138,899 per year, or $66.8 per hour.

Senior Director - Clinical Tech Design and Operations

Initial Therapeutics, Inc.

Indianapolis, IN • On-site

$157.50 - $231/hr

Other

Medical, Dental, Vision, Life, Retirement, PTO

Posted 6 days ago

Job description

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us.

Position Summary

This M3 leader directs the technology strategy and delivery for Clinical Design and Operations, leading through subordinate managers and holding leadership responsibility for a portfolio of clinical technology capabilities. The role requires technical knowledge and cross-functional leadership, an understanding of how clinical design and operations interacts with other business areas to achieve functionalobjectives, and the judgment to make decisions with significant impact on the function. Consistent with Lilly's technology direction, this leader is technically fluent and deeply AI-aware—championing AI and agentic adoption, resolving complex technical challenges, and ensuring teams build modern, compliant, high-value solutions.

Key Responsibilities
  • Lead the Clinical Design and Operations technology portfolio through subordinate managers, developing business-area plans and managing resources to meet financial and operationalobjectives.
  • Set and drive the technical and AI strategy, championing AI, agentic workflows, and intelligent automation to raise capability and value.
  • Evaluate and resolve complex business, operational, and technical challenges spanning multiple clinical capabilities.
  • Make decisions, guided by functional strategy, that significantlyimpactthe clinical design and operations function.
  • Build collaborative relationships and influence internal and external partners across multiple business areas toalign ontechnology direction.
  • Ensure portfolio solutions meetGxP, security, and quality requirements from design through delivery.
  • Maintain technical depth sufficient to guide architecture, engineering, and AI-adoption decisions and to challenge solution trade-offs.
  • Build technical and AI capability across managers and engineers through knowledge-sharing and upskilling.
  • Forecast and manage resources to meet operational and financialobjectivesacross the portfolio.
  • Represent clinical design and operations technology in governance forums, contributing to standards and investment decisions.
Basic Qualifications
  • Bachelor's degree in Computer Science, Software Engineering, Information Technology or related field.
  • Minimum 8+ years' experience in technology delivery or engineering leadership, including leadership through subordinate managers.
  • Experience delivering within Agile/SAFeenvironments and product-led operating models.
  • Strong stakeholder management, able to influence across multiple business areas and with external partners.
Preferred Qualifications
  • Technical knowledge and cross-functional leadership, with understanding of how clinical design and operationsinteractswith other business areas.
  • Hands-on experienceleveragingAI in day-to-day delivery and championing its adoption across teams.
  • Proven ability to evaluate and resolve complex business, operational, and technical problems.
  • Experience managing budgets and resources to meet financial and operationalobjectives.
  • Experience in clinical development, Good Clinical Practice (GCP), or a regulated (GxP) environment within pharmaceutical, biotech, or healthcare.
  • Advanced degree ina technical, scientific, or business discipline.
  • Working knowledge of AI/ML and agentic capabilities and their applicability to clinical operations.
  • Familiarity with enterprise/clinical architecture and platform strategy.
  • Experienceoperatingwithin a formal IT governance or product operating model.
  • Relevant leadership, Agile/SAFe, cloud, or AI certifications.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women’s Initiative for Leading at Lilly (WILL).

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is

$157,500 - $231,000

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities). Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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