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Senior Clinical Bioinformatics Jobs (NOW HIRING)

BiomeSense

Senior Bioinformatics Engineer

Chicago, IL · On-site

$125K - $200K/yr

Senior Bioinformatics Engineer Compensation: $125K - $200K base + 0.25% - 0.5% equity stock options ... Familiarity with clinical ontologies (SNOMED, ICD-11, ATC, LOINC) * Familiarity with AWS & best ...

Insmed Incorporated

Are you? About the Role: We're looking for a Senior Scientist, Bioinformatics on the Analytical ... medicine, clinical development, platform development, and data science. You'll also: * Design ...

ChromoLogic

Senior Scientist, Bioinformatics

Monrovia, CA · On-site

$90K - $120K/yr

We are seeking an innovative and highly motivated Senior Scientist, Bioinformatics to lead the ... Partner with molecular biologists, experimental scientists, clinicians, and external collaborators ...

ChromoLogic

Senior Scientist, Bioinformatics

Monrovia, CA · On-site

$90K - $120K/yr

We are seeking an innovative and highly motivated Senior Scientist, Bioinformatics to lead the ... Partner with molecular biologists, experimental scientists, clinicians, and external collaborators ...

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Senior Clinical Bioinformatics information

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$102.3K

$119.5K

How much do senior clinical bioinformatics jobs pay per year?

As of Aug 14, 2026, the average yearly pay for senior clinical bioinformatics in the United States is $102,271.00, according to ZipRecruiter salary data. Most workers in this role earn between $94,500.00 and $110,000.00 per year, depending on experience, location, and employer.

What is the difference between Senior Clinical Bioinformatics vs Clinical Bioinformatics Specialist?

AspectSenior Clinical BioinformaticsClinical Bioinformatics Specialist
CredentialsTypically requires advanced degrees (Master's or PhD) and experienceUsually requires a relevant bachelor's or master's degree, with less emphasis on extensive experience
Work EnvironmentOften involved in leadership, project management, and strategic planning within healthcare or biotech companiesPrimarily focused on data analysis, pipeline development, and supporting clinical research teams
Employer & Industry UsageUsed in hospitals, biotech firms, and research institutions for overseeing clinical genomics projectsCommonly employed in clinical laboratories, research institutions, and healthcare settings for data processing

The main difference between Senior Clinical Bioinformatics and Clinical Bioinformatics Specialist lies in experience level, responsibilities, and scope. Senior roles typically involve leadership and strategic planning, while specialists focus on data analysis and technical support. Both roles require strong bioinformatics skills, but senior positions demand more extensive experience and often involve managing projects or teams.

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Cities with the most Senior Clinical Bioinformatics job openings:

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Senior Clinical Bioinformatics jobs near you
Infographic showing various Senior Clinical Bioinformatics job openings in the United States as of August 2026, with employment types broken down into 3% As Needed, 72% Full Time, 17% Part Time, and 8% Contract. Highlights an 95% Physical, 1% Hybrid, and 4% Remote job distribution, with an average salary of $102,271 per year, or $49.2 per hour.

Senior Bioinformatics Engineer

BiomeSense

Chicago, IL • On-site

$125K - $200K/yr

Full-time

Re-posted 24 days ago

Job description

Senior Bioinformatics Engineer
Compensation: $125K – $200K base +  0.25% - 0.5% equity stock options
About BiomeSense
BiomeSense is a life sciences startup applying gut microbiome (GMB) technologies (GutLab, MetaBiome) to advance personalized medicine. We partner with UCSF, UCSD, NIH & the University of Chicago & are backed by LabCorp Ventures, Bluestein Ventures, Seerave Foundation & Emil Capital Partners.
Position
Help build our MetaBiome platform, a software solution for collecting, curating & analyzing longitudinal GMB & health data at scale. Own the infra, pipelines & analytical workflows that turn raw sequencing data into intelligence, with room to grow into a platform leader.
Responsibilities:
  • Bioinformatics Architecture & Infrastructure - design, implement & maintain auditable backend for GMB data from raw shotgun metagenomic sequencing
  • Data Engineering – build & maintain cloud infra: databases, distributed computing workflows & REST endpoints for microbial sequence & clinical metadata
  • Statistical Analysis – Lead design, execution & documentation of reproducible computational experiments end-to-end
  • Methods Development – Develop & implement novel analytical methodologies & algorithms informed by experimental findings & validated via rigorous evaluation
  • Frontend / Backend Development – Design & implement robust data ingestion interfaces leveraging APIs & clinical ontologies, following best practices

Qualifications
Required
  • B.S. /M.S. /PhD in Computational Biology, Bioinformatics or a related field with 3+ yrs industry experience (biotech start-up ideal)
  • Proficiency in Python & JavaScript & experience in production-quality software
  • PostgreSQL or other relational SQL database proficiency
  • Familiarity with clinical ontologies (SNOMED, ICD-11, ATC, LOINC)
  • Familiarity with AWS & best practices in computer security
  • Proficiency with modern frontend web technologies
  • Excellent communication; translates complex scientific concepts to diverse stakeholders
  • Strong ownership mindset & the ability to execute in fast-moving environments
  • Expertise in bioinformatics pipelines, QC & reproducibility

Preferred
  • NGS data experience
  • Familiarity with longitudinal / repeated-measures biological datasets & GMB-specific challenges (compositional data, variability, confounders)
  • Experience integrating ontologies / standardized vocabularies
  • Exposure to cloud infrastructure, workflow orchestration or containerization
  • Interest in AI/ML for large biological datasets

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