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Senior Clinical Bioinformatics Jobs (NOW HIRING)

NYULMC

Senior Bioinformatics Programmer

New York, NY · On-site

... clinical bioinformatics team. We have an exciting opportunity to join our team as a Senior ... Bioinformatics Programmer. The successful candidate will be primarily responsible for the ...

BiomeSense

Senior Bioinformatics Engineer

Chicago, IL · On-site

$125K - $200K/yr

Senior Bioinformatics Engineer Compensation: $125K - $200K base + 0.25% - 0.5% equity stock options ... Familiarity with clinical ontologies (SNOMED, ICD-11, ATC, LOINC) * Familiarity with AWS & best ...

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Senior Clinical Bioinformatics information

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$119.5K

How much do senior clinical bioinformatics jobs pay per year?

As of Jul 2, 2026, the average yearly pay for senior clinical bioinformatics in the United States is $102,271.00, according to ZipRecruiter salary data. Most workers in this role earn between $94,500.00 and $110,000.00 per year, depending on experience, location, and employer.

What is the difference between Senior Clinical Bioinformatics vs Clinical Bioinformatics Specialist?

AspectSenior Clinical BioinformaticsClinical Bioinformatics Specialist
CredentialsTypically requires advanced degrees (Master's or PhD) and experienceUsually requires a relevant bachelor's or master's degree, with less emphasis on extensive experience
Work EnvironmentOften involved in leadership, project management, and strategic planning within healthcare or biotech companiesPrimarily focused on data analysis, pipeline development, and supporting clinical research teams
Employer & Industry UsageUsed in hospitals, biotech firms, and research institutions for overseeing clinical genomics projectsCommonly employed in clinical laboratories, research institutions, and healthcare settings for data processing

The main difference between Senior Clinical Bioinformatics and Clinical Bioinformatics Specialist lies in experience level, responsibilities, and scope. Senior roles typically involve leadership and strategic planning, while specialists focus on data analysis and technical support. Both roles require strong bioinformatics skills, but senior positions demand more extensive experience and often involve managing projects or teams.

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Senior Clinical Bioinformatics jobs near you

Sr. Clinical Bioinformatics Scientist

myDNA, Inc.

Houston, TX • On-site

Full-time

Medical, Dental, Vision, Retirement, PTO

Posted 12 days ago

Job description

Our Purpose
Our mission is to build a healthier and more connected world with precision health and genealogy services. We empower individuals with actionable insights into their genetic makeup, fostering a deeper understanding of their ancestry, health, and wellness. By integrating the experience of Gene by Gene Laboratory Services, FamilyTreeDNA genealogy, and myDNA reporting services, we strive to deliver cutting-edge genetic testing and personalized solutions that inspire informed decisions and enhance quality of life. Our team is dedicated to advancing the field of genomics through innovation, research, and a commitment to excellence.
Our Values
All employees are expected to demonstrate our values of Innovate, One Team, and Integrity when carrying out the accountabilities and responsibilities of their role. This how we show up every day for ourselves, our colleagues and our customers and strategic partners to deliver our vision and strategic goals.
Position Overview
Gene By Gene is seeking a senior-level Clinical Bioinformatics Scientist to develop and maintain high-throughput genomic pipelines in a regulated clinical laboratory environment (CLIA/CAP). The position will involve transforming raw next generation sequencing (NGS) data into actionable clinical insights, ensuring the accuracy, scalability, and security of diagnostic assays.
Accountabilities and Responsibilities
  • Pipeline Development: Design, optimize, and validate new automated bioinformatics workflows for genetic variant calling, including the following:
    • Using or developing software to receive, process, and analyze genetic data.
    • Assessing software and programs for suitability to achieve desired analysis goals
    • Determination of appropriate analysis parameters and thresholds for identification and evaluation of genetic markers of interest
    • Designing defined analysis protocols within the software for routine use by other data analysts, including pre-set filters and settings
    • Validation of developed protocols to demonstrate accurate generation and reporting of results
    • Writing or revising code to aid in the processing or analysis of samples though the lab
  • Variant Analysis: Use developed analysis pipelines to implement algorithms for detection of SNV's, Indels, CNV's, and structural variants from genetic data.
  • Clinical Validation: Complete and document the analytical validation of bioinformatics tools to meet regulatory requirements for clinical use, including the analytical validity of risk models to satisfy CLIA / CAP / ACMG requirements.
  • Data Management: Oversee large-scale genomic datasets, ensuring data integrity, security, and HIPAA compliance
  • Quality Control: Establish automated QC metrics to monitor run performance and data integrity.
  • Collaboration: Work with laboratory directors, clinical geneticists, the research and development team, and IT professionals to integrate and implement bioinformatics tools to fulfill client reporting requirements.
  • Report Generation: Work with laboratory directors, clinical geneticists, and IT professionals to create clinically validated reporting pipelines for genetic data interpretation, including Monogenic and Polygenic Risk Scores, Pharmagogenomics (PGx) interpretation, and Carrier Screening.
  • Troubleshooting: Resolve technical issues in production pipelines to prevent delays in client report generation and delivery.

Position Requirements
  • Doctoral Degree in Bioinformatics, Computational Biology, Statistical Genetics, or a related field with 5+ years post-graduate experience.
  • Understanding of general molecular biology and genetic laboratory procedures.
  • Ability to apply theoretical knowledge of genetics towards interpretation of genetic data to generate clinical reports.
  • Expertise with bioinformatics principles and ability to apply this knowledge towards implementation of genetic analysis programs and clinical report generation pipelines.
  • Knowledge of clinical laboratory regulatory requirements for clinical diagnostics and reporting, including familiarity with HIPAA, CLIA, NYSDOH CLEP standards, and ACMG variant interpretation classifications.
  • Understanding of population genetics and statistical modeling to account for ancestry, ethnicity, and environmental factors in the calculation of risk scores for complex traits.
  • Understanding of genetic imputation and haplotype phasing determination, and ability to ensure that imputed data meets strict quality control thresholds for clinical use.
  • Familiarity with machine learning for genomic functional prediction and pattern recognition.
  • Familiarity with multiple NGS instrumentation platforms and their file formats (eg. Illumina, Ultima Genomics, Complete Genomics, Oxford Nanopore, etc.) and ability to create platform agnostic analysis pipelines, adaptable to various platforms.
  • Expertise or Familiarity with the following (or similar) environments, databases, coding languages, software suites, data analysis tools, etc.:
    • Command Line, Python, R, Java, shell scripting (Bash)
    • SQL and database administration
    • Strong command of Linux/Unix environments
    • Cloud computing (AWS, Google Cloud, or Azure)
    • Containerization (Docker, Kubernetes)
    • Software version control tools (Git)
    • NGS analysis tools and variant annotation databases: FastQC, Samtools, Bamtools, VCFTools, BWA, GATK, ClinVar, gnomAD
    • Bioinformatics tools for analysis of large-scale genomic data (PLINK, Eagle2, Beagle, etc.)
    • Workflow managers (Nextflow or similar)
    • Genetic databases and reference standard repositories (NCBI GenBank, RefSeq, ENSEMBL, Genome Reference Consortium etc.)
    • Global and population-specific genetic reference panels (TOPMed, 1000 Genomes Project, Haplotype Reference Consortium, GenomeAsia, African Genome Resource, etc.)

Why Join Us
At Gene by Gene, you'll join a mission-driven team advancing the science of genetics and discovery. You'll have the opportunity to shape meaningful campaigns, tell compelling brand stories, and collaborate with talented professionals who share your passion for creativity, curiosity, and impact.
Comprehensive Benefits
  • Medical & Health Savings: Choice of 3 medical tiers generously sponsored by the company, with a monthly $50-$100 employer HSA contribution based on plan type and dependent level.
  • 100% Covered Dental & Vision: No premium costs for employees or dependents.
  • 401(k) Matching: Generous 50% company match up to 6% of annual base salary.
  • Diverse PTO Framework: Structured time off incorporating vacation, sick leave, mental health days, personal days, company holidays, and a flexible floating holiday.
  • Income Protection & Family Leave: Full company sponsorship of Short-Term and Long-Term Disability (STD/LTD) alongside Paid Family Leave offerings.

Apply