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Senior Bioinformatics Scientist Jobs (NOW HIRING)

Natera

Senior Bioinformatics Scientist

San Carlos, CA · On-site

Natera is seeking a Senior Bioinformatics Scientist to lead the architecture, development, and automation of high-throughput genomic pipelines. This role is responsible for building production-grade ...

Natera

OR · On-site

Natera is seeking a Senior Bioinformatics Scientist to lead the architecture, development, and automation of high-throughput genomic pipelines. This role is responsible for building production-grade ...

Foundation Medicine

Sr. Bioinformatics Scientist

Boston, MA · Hybrid

$145K - $170K/yr

The Senior Bioinformatics Scientist is responsible for supporting novel biomarker definition, biomarker analysis, development, and validation for FMI CDx programs. The incumbent mentors or supervises ...

Vivo HealthStaff

Bioinformatics Scientist

Boston, MA · On-site

$170K - $190K/yr

Bioinformatics Scientist (Mid/Senior) Compensation: $170,000 - $190,000 Location: South San Francisco, CA Job Type: Full-time ( Hybrid ) Equity: Highly Competitive Equity About Our Client ...

Vivo HealthStaff

Bioinformatics Scientist

Boston, MA · On-site

$170K - $190K/yr

Bioinformatics Scientist (Mid/Senior) Compensation: $170,000 - $190,000 Location: South San Francisco, CA Job Type: Full-time ( Hybrid ) Equity: Highly Competitive Equity About Our Client ...

Apply Early

Vivo HealthStaff

Bioinformatics Scientist

Winter Park, FL · On-site

$150K - $180K/yr

Bioinformatics Scientist (Mid/Senior) Compensation: $150,000 - $180,000 Location: San Francisco, CA Job Type: Full-time ( Hybrid ) Equity: Highly Competitive Equity About Our Client Vivo HealthStaff ...

Vivo HealthStaff

Bioinformatics Scientist

Boston, MA

$170K - $190K/yr

Bioinformatics Scientist (Mid/Senior) Compensation: $170,000 - $190,000 Location: South San Francisco, CA Job Type: Full-time ( Hybrid ) Equity: Highly Competitive Equity About Our Client ...

Vivo HealthStaff

Bioinformatics Scientist

Boston, MA

$170K - $190K/yr

Bioinformatics Scientist (Mid/Senior) Compensation: $170,000 - $190,000 Location: South San Francisco, CA Job Type: Full-time ( Hybrid ) Equity: Highly Competitive Equity About Our Client ...

Vivo HealthStaff

Bioinformatics Scientist

Boston, MA · On-site

$170K - $190K/yr

Bioinformatics Scientist (Mid/Senior) Compensation: $170,000 - $190,000 Location: South San Francisco, CA Job Type: Full-time ( Hybrid ) Equity: Highly Competitive Equity About Our Client ...

Apply Early

Vivo HealthStaff

Bioinformatics Scientist

Winter Park, FL · On-site

$170K - $190K/yr

Bioinformatics Scientist (Mid/Senior) Compensation: $150,000 - $180,000 Location: San Francisco, CA Job Type: Full-time ( Hybrid ) Equity: Highly Competitive Equity About Our Client Vivo HealthStaff ...

Vivo HealthStaff

Bioinformatics Scientist

Winter Park, FL · On-site

$170K - $190K/yr

Bioinformatics Scientist (Mid/Senior) Compensation: $150,000 - $180,000 Location: San Francisco, CA Job Type: Full-time ( Hybrid ) Equity: Highly Competitive Equity About Our Client Vivo HealthStaff ...

Apply Early

Vivo HealthStaff

Bioinformatics Scientist

Ann Arbor, MI · On-site

$170K - $190K/yr

Bioinformatics Scientist (Mid/Senior) Compensation: $170,000 - $190,000 Location: South San Francisco, CA Job Type: Full-time ( Hybrid ) Equity: Highly Competitive Equity About Our Client ...

Apply Early

Vivo HealthStaff

Bioinformatics Scientist

Boston, MA · On-site

$170K - $190K/yr

Bioinformatics Scientist (Mid/Senior) Compensation: $170,000 - $190,000 Location: South San Francisco, CA Job Type: Full-time ( Hybrid ) Equity: Highly Competitive Equity About Our Client ...

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Senior Bioinformatics Scientist information

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How much do senior bioinformatics scientist jobs pay per year?

As of Jul 3, 2026, the average yearly pay for senior bioinformatics scientist in the United States is $101,443.00, according to ZipRecruiter salary data. Most workers in this role earn between $57,500.00 and $137,500.00 per year, depending on experience, location, and employer.

What are the primary responsibilities of a Senior Bioinformatics Scientist on a day-to-day basis?

Senior Bioinformatics Scientists typically design and implement analytical workflows to process large-scale biological datasets, such as genomic or transcriptomic data. They frequently collaborate with laboratory scientists and research teams to interpret results and guide experimental design. Additional responsibilities often include developing custom software tools, publishing research findings, mentoring junior team members, and staying updated on emerging technologies in the field. This combination of tasks ensures both the quality of analyses and the continuous innovation within research projects.

What are the key skills and qualifications needed to thrive in the Senior Bioinformatics Scientist position, and why are they important?

To thrive as a Senior Bioinformatics Scientist, you need expertise in computational biology, data analysis, and molecular biology, typically with an advanced degree such as a PhD in bioinformatics, computational biology, or a related field. Familiarity with programming languages (such as Python, R), bioinformatics pipelines, databases, and experience with high-performance computing environments is crucial. Strong problem-solving skills, effective communication, and the ability to lead cross-disciplinary teams are key soft skills in this role. These abilities ensure accurate data interpretation, successful project collaboration, and advancement of scientific research initiatives.

What does a Senior Bioinformatics Scientist do?

A Senior Bioinformatics Scientist analyzes complex biological data using computational tools and algorithms, often focusing on genomics, proteomics, or transcriptomics. They design and implement bioinformatics pipelines, develop software solutions, and collaborate with biologists to interpret results. Their role includes managing large datasets, optimizing data processing workflows, and contributing to scientific publications. Additionally, they may mentor junior scientists and lead research projects to advance biological discoveries.

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Senior Bioinformatics Scientist jobs near you
Infographic showing various Senior Bioinformatics Scientist job openings in the United States as of June 2026, with employment types broken down into 6% As Needed, 63% Full Time, 1% Part Time, and 30% Contract. Highlights an 92% Physical, 2% Hybrid, and 6% Remote job distribution, with an average salary of $101,443 per year, or $48.8 per hour.
Senior Bioinformatics Scientist

Senior Bioinformatics Scientist

Natera

San Carlos, CA • On-site

Other

Posted 14 days ago

Natera rating

7.7

Company rating: 7.7 out of 10

Based on 35 frontline employees who took The Breakroom Quiz

50th of 103 rated laboratories

Job description

Natera is seeking a Senior Bioinformatics Scientist to lead the architecture, development, and automation of high-throughput genomic pipelines. This role is responsible for building production-grade software tools to analyze next-generation sequencing (NGS) data including variant calling, fusion detection, and data quality control. The ideal candidate combines a deep understanding of sequence alignment algorithms with strong object-oriented programming skills to design scalable computational workflows in a fast-paced, mission-driven environment.

Primary Responsibilities:

  • Analyze complex genomic datasets leveraging scaled in-house pipelines, partnering cross-functionally with wet-lab scientists and statisticians to rapidly deliver data-driven answers to critical research goals.
  • Architect, build, and deploy automated analysis pipelines for diagnostic tests, integrating robust capabilities for fusion detection, variant calling, and automated quality control metrics.
  • Engineer novel genomic analysis tools and proactively identify optimization pathways to enhance pipeline accuracy and efficiency.
  • Participate in code reviews, technical documentation, and the continuous improvement of core computational workflows.
  • Coordinate directly with downstream infrastructure teams to ensure R&D tools scale efficiently into production systems.

Qualifications:

  • Ph.D. in Bioinformatics, Computer Science, Engineering, Biochemistry, or a related quantitative field with 0-3 years of professional experience
  • Masters in Bioinformatics, Computer Science, Engineering, Biochemistry, or a related quantitative field with 4-6 years of professional experience 

Knowledge, Skills, and Abilities:

  • Deep theoretical and practical understanding of high-throughput DNA sequence data analysis, including mapping, sequence alignment, and variant calling workflows.
  • Advanced understanding of data structures, algorithm design, and computational complexity.
  • Strong Python programming skills, including fluency with the scientific computing stack (NumPy, Pandas, Scikit-learn) for data manipulation, analysis, and automation.
  • Proficiency with workflow languages - Nextflow or WDL strongly preferred - for developing, versioning, and deploying scalable bioinformatics pipelines.
  • Extensive experience in distributed computing and cloud environments; AWS strongly preferred, with hands-on use of cloud-native tools such as AWS Batch, S3, or Lambda.
  • Deep expertise navigating Linux environments, utilizing command-line tools, and writing efficient shell scripts.
  • Demonstrated technical autonomy and rigorous data discipline when troubleshooting high-complexity algorithmic challenges.
  • Excellent communication skills with a proven track record of explaining computational results clearly to cross-functional stakeholders.
  • Prior experience working with relational databases, particularly MySQL, is highly desirable.

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