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Remote Trial Master File Jobs in Massachusetts (NOW HIRING)

Dana-Farber Cancer Institute

This position's work location is fully remote with occasional time on-campus in [enter location ... Trial Master File (TMF) Development and Maintenance: Develop and maintain the TMF, ensuring all ...

DeepHealth

Sr. Clinical Studies Associate

Boston, MA · On-site +1

$85 - $95/hr

Ensure timely filing, quality review, and completeness of Trial Master File (TMF) documentation ... Travel This position requires domestic / international travel up to 10%. Working Environment Remote ...

New

Alira Health

Reconciles the ISF with the Trial Master File (TMF), ensuring filing of essential documents in ... Ability to work in an environment of remote collaborators. * EU (Italy): Certified Monitor in ...

IQVIA

Trial Delivery Manager, Multi TA

Boston, MA · Remote

Clinical Trial Management & Central Trial Oversight (FSP Model) Home Based Remote Role - East Coast ... Oversee trial documentation, filing, archiving, and retention. * Create, review, and maintain trial ...

ARTBIO

Senior Clinical Trial Manager

Cambridge, MA · On-site +1

Perform clinical research site activities, which can include onsite or remote monitoring, co ... Bachelor's or Master's degree in Life Sciences, Nursing, Pharmacy, or a related field. * 5 to 8 ...

ARTBIO

Senior Clinical Trial Manager

Cambridge, MA · On-site +1

Perform clinical research site activities, which can include onsite or remote monitoring, co ... Bachelor's or Master's degree in Life Sciences, Nursing, Pharmacy, or a related field. * 5 to 8 ...

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Remote Trial Master File information

What are the key skills and qualifications needed to thrive as a Remote Trial Master File (TMF) Specialist, and why are they important?

To thrive as a Remote Trial Master File (TMF) Specialist, you need a solid understanding of clinical trial processes, regulatory requirements (such as ICH-GCP), and experience with TMF management, often supported by a degree in life sciences or a related field. Familiarity with electronic TMF (eTMF) systems, document management software, and compliance tracking tools is typically required. Attention to detail, organizational skills, and strong communication are vital soft skills to ensure accurate documentation and effective collaboration across remote teams. These skills and qualifications are crucial for maintaining regulatory compliance, ensuring data integrity, and supporting the smooth conduct of clinical trials.

What is the difference between Remote Trial Master File vs Clinical Trial Associate?

AspectRemote Trial Master FileClinical Trial Associate
CredentialsTypically requires knowledge of GCP, ICH guidelines, and document managementRequires knowledge of clinical trial processes, GCP, and data entry
Work EnvironmentRemote, document management systems, cloud-based platformsOffice or site-based, assisting with trial coordination and data collection
Industry UsageUsed across pharmaceutical, biotech, and CROs for document oversightCommonly employed in clinical research teams for trial support

The Remote Trial Master File focuses on managing and maintaining essential trial documents remotely, ensuring compliance and accessibility. In contrast, a Clinical Trial Associate supports trial activities on-site or remotely, handling data collection and coordination. Both roles are vital in clinical research but differ mainly in scope and responsibilities.

What are the main challenges of managing a Trial Master File (TMF) remotely, and how can they be addressed?

Managing a TMF remotely often presents challenges such as maintaining document version control, ensuring regulatory compliance, and facilitating timely collaboration across dispersed teams. To address these, many organizations utilize secure cloud-based eTMF systems that allow real-time access and updates, implement clear document management protocols, and schedule regular virtual check-ins with team members. Strong communication skills and familiarity with electronic documentation tools are essential for success in this remote environment.

What is a Remote Trial Master File (TMF) and what does the role involve?

A Remote Trial Master File (TMF) professional is responsible for managing and maintaining essential documents related to clinical trials in a digital or remote environment. This role ensures that all regulatory and compliance requirements are met by organizing, tracking, and archiving important trial documentation. Working remotely, TMF specialists collaborate with clinical research teams, auditors, and regulatory authorities to ensure data integrity and readiness for inspections. The job often involves using specialized electronic TMF (eTMF) systems to facilitate secure access and management of files from different locations.
What are the most commonly searched types of Trial Master File jobs in Massachusetts? The most popular types of Trial Master File jobs in Massachusetts are:
What are popular job titles related to Remote Trial Master File jobs in Massachusetts? For Remote Trial Master File jobs in Massachusetts, the most frequently searched job titles are:
What job categories do people searching Remote Trial Master File jobs in Massachusetts look for? The top searched job categories for Remote Trial Master File jobs in Massachusetts are:
What cities in Massachusetts are hiring for Remote Trial Master File jobs? Cities in Massachusetts with the most Remote Trial Master File job openings:
Remote Trial Master File jobs near you
Infographic showing various Remote Trial Master File job openings in Massachusetts as of July 2026, with employment types broken down into 100% Contract. Highlights an 100% Remote job distribution.

Clinical Trial Associate - Oncology

Obsidian Therapeutics

Bedford, MA • On-site, Remote

$35.25 - $48/hr

Full-time

Medical, Dental, Vision, Retirement, PTO

Posted 16 days ago

Job description

About Us
Obsidian Therapeutics is pioneering engineered cell and gene therapies to deliver transformative outcomes for patients. Obsidian's programs apply our cytoDRiVE® technology in Cell and Gene therapy products to control expression of proteins for enhanced therapeutic efficacy and safety. Obsidian's lead program is currently in clinical development for the treatment of patients with metastatic melanoma and non-small cell lung cancer.
We're proud of our diverse talented team and committed to cultivating an environment of inclusion where each person feels a strong sense of belonging and is supported to continuously learn and contribute their best work. Our Research team is based in the heart of Cambridge, MA, and Technical Operations team is based in our purpose built facility in Bedford, MA. Obsidianites enjoy a highly collaborative culture, competitive salary and benefits, and potential for ownership through stock options.
Our Opportunity...
We are looking for a highly motivated Clinical Trial Associate, with a background in Oncology and/or Cell Therapy clinical trials. As a key contributor within Clinical Operations, you'll help drive the development of our first clinical stage autologous cell therapy trial targeting solid tumors.
You'll play a key role in driving the operational execution of complex clinical trials, supporting cross-functional coordination, vendor oversight, and ensuring high-quality, inspection-ready study delivery. As a member of our Clinical Operations Team, you will be a vital part of a highly collaborative organization working to achieve Obsidian's vision by translating innovative science into medical breakthroughs for patients starting with our lead program OBX-115, a novel engineered tumor-infiltrating lymphocyte (TIL) therapy.
This is a unique opportunity to be a contributor in a well-funded clinical stage company with blue chip investors, field-leading advisors, best-in-class partners, and an experienced team. You'll help us build a dynamic, innovative, passionate, collaborative, and successful organization focused on delivering transformative therapies in areas of greatest clinical need.
This is a Hybrid role based out of our Bedford, MA location.
You Will...
Core responsibilities
  • Support day-to-day clinical trial operations in alignment with protocols, timelines, and regulatory requirements.
  • Serve as a point of coordination across internal teams, CROs, and external partners.
  • Maintain the Trial Master File (TMF), ensuring completeness, accuracy, and audit readiness.
  • Perform TMF quality control activities and proactively address gaps.
  • Support audits and inspections, including preparation and follow-up activities.
  • Coordinate with vendors, including central labs and specialty service providers.
  • Support biospecimen tracking, logistics, and associated documentation.
  • Track and monitor vendor performance and escalate issues as needed.
  • Develop, maintain, and improve study tracking tools (e.g., enrollment, sample tracking, timelines).
  • Ensure data accuracy and timely reporting across study activities.
  • Contribute to improvements in clinical operations processes and systems.
  • Facilitate clear, timely communication across study teams and stakeholders.
  • Coordinate study meetings, including agenda development, minutes, and follow-up actions.
  • Maintain version control and documentation across clinical materials.
  • Support invoice tracking, purchase order coordination, and budget-related activities.

You Bring...
Core Qualifications
  • BS/BA/RN Degree with 3+ years of experience in a life science or a health-related field is preferred.
  • 1+ years working on phase I-IV clinical studies within a biopharmaceutical/biotech, CRO, or academic environment.
  • Experience and understanding of clinical trial operations, preferably in oncology and/or cell therapy space.
  • Solid knowledge of ICH/GCP and regulatory requirements.
  • Excellent planning, coordination, and time management skills
  • Excellent oral, written, and visual communication skills. You listen to understand and communicate effectively and persuasively with partners, colleagues, and leadership.
  • Ability to build and maintain productive relationships at all levels within and across internal teams, and with external partners.
  • Collaborative and accountable - recognizes success requires teamwork and interdisciplinary thinking; shares feedback and ideas to facilitate better outcomes
  • Self-motivated, with a proven ability to meet objectives, timelines, and high standards managing multiple responsibilities in parallel.
  • Flexible - adapts to change in a fast paced, rapidly developing environment
  • Curious and humble - continuous learner, seeks and welcomes input/expertise of others
  • Tenacious and resilient - is not easily overwhelmed by challenges, delivers on commitments, operates with urgency.

Bonus Qualifications
  • Proficiency in Microsoft Project or other project management programs.

Obsidian is committed to equitable and transparent pay practices.
The anticipated base salary range for this role is below. The actual base salary offered will be determined based on a combination of factors, including applicable qualifications, level of education, the depth of experience, unique skills, geographic location, internal equity, and/or business needs. The actual base salary offered will be in accordance with federal, state, and/or local wage requirements for the role's location.
Our competitive compensation package includes an annual incentive bonus as a percentage of actual base salary and long-term incentives in the form of employee stock options, both of which are commensurate with the role's level. We also offer a generous benefits package which includes comprehensive medical, dental, and vision coverage; company contributions to health savings and retirement accounts; ample paid time off; access to wellness programs; and rich career growth opportunities.
Anticipated Base Salary Range
$92,000-$112,500 USD
Obsidian is proud to be an equal opportunity employer, cultivating a welcoming and diverse environment. All applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, veteran status or any other applicable legally protected characteristics.

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