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Remote Python Startup Jobs (NOW HIRING)

SmarterDx

Staff Software Engineer, Machine Learning

$260K/yr

This role is fully remote within the US** What You'll Do * Build and scale machine-learning driven ... Strong proficiency in Python and SQL, with experience in machine learning libraries (Pytorch ...

Averity

Senior Full-Stack Engineer

Manhattan, NY · Remote

$200K - $250K/yr

A stealth-mode startup is assembling a world-class team to build the first AGI-powered investor: a ... Python, TypeScript/JavaScript * Infra : AWS, Modal, Prefect, Snowflake * Other : SQL Role Details:

Swish Analytics

Rust Engineer

San Francisco, CA · On-site +1

$170K/yr

Company Description Swish Analytics is a sports analytics, betting and fantasy startup building the ... Proactively improve our Rust and Python codebase * Production model feature deep dives to explain ...

Swish Analytics

Sports Data Analyst

San Francisco, CA · On-site +1

Company Description Swish Analytics is a sports analytics, betting and fantasy startup building the ... Source origins of data inaccuracies through data pipeline dependencies and python code base

twenty80.io

Senior Full Stack Software Engineer

Boston, MA · On-site +1

$160K - $210K/yr

Backend: Node.js (Express or NestJS) and/or Python (Django or FastAPI) * Databases: PostgreSQL ... flexible PTO; standard startup benefits * Work Model: Hybrid or remote-friendly depending on ...

SmarterDx

Senior Software Engineer, Machine Learning

$190/hr

This role is fully remote within the US** What You'll Do * Build and scale machine-learning driven ... Strong proficiency in Python and SQL, with experience in machine learning libraries (Pytorch ...

Chasm Select

Senior Machine Learning Engineer

Manhattan, NY · On-site +1

$150K - $180K/yr

Remote (For Non-Local) or Hybrid (Local to NYC area) Position Summary: Join our mission to infuse ... Most importantly, we are a mission-oriented, high-growth startup and we are looking for folks that ...

ICONSTAFF

Senior Backend Engineer

Boston, MA · Remote

$160K - $240K/yr

Strong Python skills and experience with large-scale systems * Solid understanding of APIs ... Startup or full-stack experience Additional Info * Fully remote (U.S. only) * Competitive salary ...

OSI Engineering, Inc.

Senior AI Engineer

Cupertino, CA · On-site +1

$58 - $68/hr

Strong TypeScript development experience ( Python a plus) * Experience building AI-powered ... Startup or highly autonomous engineering experience preferred Education & Experience * Bachelor ...

Cypress HCM

Full Stack Developer

Atlanta, GA · On-site +1

$80K - $100K/yr

Remote from Atlanta, GA | In-office time (ATDC) will be available to you but isn't mandated ... Working in a highly autonomous environment at an early-stage startup with financial backing and ...

Pipe Technologies

Senior Software Engineer

$150K - $220K/yr

We are hiring a Senior Backend Engineer to work in our Go, Python, and Postgres stack. You'll work ... You want to join a remote-first startup and make an impact. * You want to be part of a team that ...

Cloudacio

Data Engineer (Contract) (Remote)

Manhattan, NY · Remote

$126K - $151K/yr

Core Skills: * Strong proficiency in Python * Experience with SQL and NoSQL databases (e.g ... Previous consulting or startup environment experience. * Ability to independently handle customer ...

SmarterDx

Staff Software Engineer, Full Stack

$230K - $250K/yr

This role is fully remote within the US** What You'll Do * Design, build and launch new multi ... Expertise in TypeScript, React, and Python * Experience working on software that aids in decision ...

Hired Recruiters

Senior DevOps Engineer

Austin, TX · On-site +1

$128K - $165K/yr

Remote * Salary $150k - $200k * Seed Company * Skills: Ansible, Bash, Python, Terraform, Docker ... Experience working at a venture-backed early-stage startup * B.S., or M.S., in Computer Science or ...

Transparent Hiring

$106K - $128K/yr

... in startup environments (fast-moving, hands-on, limited resources) * Strong skills in Python and ... Remote-first across Germany and the US (offices available). * Relocation to Germany is supported by ...

Miller Cooper

QA Automation Engineer

Chicago, IL · Remote

$85K - $95K/yr

Join a startup company with over 100 healthcare clients and growing! * Fully remote role that has a ... Experience with Python or JavaScript * Strong debugging skills * Legal authorization to work in the ...

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Remote Python Startup information

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How much do remote python startup jobs pay per hour?

As of Jun 20, 2026, the average hourly pay for remote python startup in the United States is $58.62, according to ZipRecruiter salary data. Most workers in this role earn between $48.32 and $66.59 per hour, depending on experience, location, and employer.

What is a Remote Python Startup?

A Remote Python Startup is a company or organization that is in its early stages of development and primarily operates remotely, with its team members working from different locations. The startup's core products or services are typically built using the Python programming language, which is known for its versatility and ease of use in web development, data science, automation, and more. Working at a remote Python startup often requires strong collaboration skills, self-motivation, and proficiency in Python and related technologies. Team members typically communicate through online tools and platforms to manage projects, build products, and solve problems together.

What are the key skills and qualifications needed to thrive as a Remote Python Developer at a startup, and why are they important?

To thrive as a Remote Python Developer at a startup, you need strong proficiency in Python programming, problem-solving abilities, and experience with web frameworks or APIs, often supported by a degree in computer science or related field. Familiarity with tools like Git, Docker, cloud platforms (AWS, GCP), and continuous integration systems is typically required. Self-motivation, adaptability, and excellent written communication are crucial soft skills for collaborating within distributed, fast-paced startup teams. These skills ensure you can deliver effective solutions, adapt to evolving priorities, and contribute positively to the startup's growth and remote culture.

What is the difference between Remote Python Startup vs Remote Data Analyst?

AspectRemote Python StartupRemote Data Analyst
Required CredentialsPython programming skills, possibly some web frameworks, basic data handlingStatistical knowledge, data analysis tools, SQL, possibly some programming
Work EnvironmentTech startups, flexible remote settings, collaborative teamsBusiness or tech companies, remote or hybrid, focus on data insights
Industry UsageSoftware development, startups, tech industryFinance, marketing, healthcare, and other data-driven sectors

Remote Python Startup roles focus on software development using Python, often in startup environments, while Remote Data Analyst positions emphasize analyzing data to inform business decisions. Both roles require technical skills but differ in focus and industry application.

How does working at a remote Python startup typically differ from larger, more established companies in terms of daily responsibilities and team collaboration?

At a remote Python startup, you can expect to wear multiple hats, often taking on responsibilities beyond strict coding, such as contributing to product decisions or helping shape development processes. Daily tasks are usually fast-paced and can shift rapidly as priorities change, requiring adaptability and strong self-motivation. Team collaboration often relies on digital tools like Slack, GitHub, and video meetings, fostering a culture of frequent communication and autonomy. This environment provides unique opportunities for rapid skill growth, direct impact on the company's success, and close collaboration with founders and cross-functional teams.
More about Remote Python Startup jobs
What cities are hiring for Remote Python Startup jobs? Cities with the most Remote Python Startup job openings:
What are the most commonly searched types of Python Startup jobs? The most popular types of Python Startup jobs are:
What states have the most Remote Python Startup jobs? States with the most job openings for Remote Python Startup jobs include:
What job categories do people searching Remote Python Startup jobs look for? The top searched job categories for Remote Python Startup jobs are:
Remote Python Startup jobs near you
Infographic showing various Remote Python Startup job openings in the United States as of June 2026, with employment types broken down into 52% Full Time, 47% Part Time, and 1% Contract. Highlights an 81% Physical, 2% Hybrid, and 17% Remote job distribution, with an average salary of $121,932 per year, or $58.6 per hour.
Staff Software Engineer, Machine Learning

Staff Software Engineer, Machine Learning

SmarterDx

Remote

$260K/yr

Full-time

Medical, Dental, Vision, Retirement, PTO

Posted 15 days ago

Job description

SmarterDx, a Smarter Technologies company, builds clinical AI that is transforming how hospitals translate care into payment. Founded by physicians in 2020, our platform connects clinical context with revenue intelligence, helping health systems recover millions in missed revenue, improve quality scores, and appeal every denial. Become a Smartian and help optimize the way the healthcare system works for everyone. Learn more at smarterdx.com/careers.
Role
We are looking for a Staff Machine Learning Engineer to help us build a best in class ML Ecosystem to advance our product suite with clinical AI. The ideal candidate works exceptionally well across disciplines and delivers high quality outcomes continuously, with a relentless focus on reliable systems and developer experience.
**This role is fully remote within the US**
What You'll Do
  • Build and scale machine-learning driven features across multiple products
  • Design reusable architecture that powers and accelerates machine learning development across the company
  • Set the standard for development and ML practices at SmarterDx and mentor other engineers

What You Bring
  • You Bring
    • 10+ years of development experience with a focus on Machine Learning and Engineering roles
    • Strong proficiency in Python and SQL, with experience in machine learning libraries (Pytorch, Tensorflow)
    • Experience with managing the full model production lifecycle, including deployment, release, and post-launch monitoring
    • Experience working with a diverse, cross-disciplinary team to integrate machine learning into product features
    • Experience with cloud platforms (preferably AWS) and their machine learning services.
    • Experience project managing a small team using a modern agile methodology
    • Experiencing influencing a cross-disciplinary organization to adopt best practices
    • Strong understanding of data engineering and architecture principles.
    • Excellent collaboration and communication skills, with a passion for solving challenging problems in a team environment.

Nice To Haves
  • You're a former startup founder, or have been the first engineering hire at a startup
  • Experience in the health tech domain, particularly in hospital billing systems
  • Experience with end-to-end machine learning project lifecycle, from data collection and model training to deployment and monitoring.
  • Deployment of LLM systems into Production environments.
  • Contributions to open-source projects or active participation in the machine learning community.

Our Tech Stack
  • Python, PyTorch, pandas/Polars, Airflow, Snowflake, dbt, AWS, MLflow, Sagemaker, Terraform, K8s
Compensation
$230-260k base salary
#LI-Remote
Benefits
  • Medical, Dental & Vision - Comprehensive plans with leading insurance providers, covering 75% of your premiums, depending on the plan.
  • Paid Parental Leave - Generous paid leave to support families through birth or adoption: Up to 12 weeks for parents.
  • Remote-First Team - Work from anywhere in the U.S.
  • Unlimited PTO & 10 Holidays - So you can relax and recharge.
  • 401(k) with Traditional & Roth Options - Tax-advantaged retirement savings through Fidelity with a 4% match.
  • Minimal Bureaucracy - A fast-moving, high-impact environment where you can focus on what matters.
  • Incredible Teammates! - Work alongside smart, supportive, and mission-driven colleagues.

Apply