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Remote Python Startup Jobs (NOW HIRING)

Career Renew

Senior ML Engineer

San Francisco, CA · Remote

$180K - $240K/yr

You're an applied AI engineer who thrives in startup environments, writes clean Python, and can ... Remote-first with strong perks -- flexible vacation, paid sabbatical after 5 years, comprehensive ...

MBR Partners

Senior Software Engineer

Chicago, IL · Remote

$150K/yr

... our client's startup where they are already No1 order-taking system for drive-thrus. They are ... Their backend is developed in Python running in the cloud over k8s. It's not a typical backend ...

Miller Cooper

Full Stack Software Engineer

Chicago, IL · Remote

Join a startup company with over 100 healthcare clients and growing! * Fully remote role that has a ... Design, develop, test, and deploy scalable backend microservices and web applications using Python ...

Mondo

Senior Software Engineer

Dallas, TX · Remote

$70 - $80/hr

Remote (PST timezone required) Start Date: ASAP Duration: 6 Month Contract-to-Hire Compensation ... Build and maintain backend services and APIs primarily using Python and Django, with some frontend ...

Employvision

Staff Software Engineer

$190K - $230K/yr

... startup Hard skills • Strong expertise in Python/Django for backend services. • Strong ... Remote work policy US-based remote Full-time position Hiring Count Looking to hire 1 candidate for ...

SmarterDx

Staff Software Engineer, Machine Learning

$260K/yr

This role is fully remote within the US** What You'll Do * Build and scale machine-learning driven ... Strong proficiency in Python and SQL, with experience in machine learning libraries (Pytorch ...

Miller Cooper

Full Stack Software Engineer

Chicago, IL · Remote

$125K - $145K/yr

Join a startup company with over 100 healthcare clients and growing! * Fully remote role that has a ... Design, develop, test, and deploy scalable backend microservices and web applications using Python ...

Swish Analytics

Rust Engineer

San Francisco, CA · On-site +1

$170K/yr

Company Description Swish Analytics is a sports analytics, betting and fantasy startup building the ... Proactively improve our Rust and Python codebase * Production model feature deep dives to explain ...

Swish Analytics

Sports Data Analyst

San Francisco, CA · On-site +1

Company Description Swish Analytics is a sports analytics, betting and fantasy startup building the ... Source origins of data inaccuracies through data pipeline dependencies and python code base

twenty80.io

Senior Full Stack Software Engineer

Boston, MA · On-site +1

$160K - $210K/yr

Backend: Node.js (Express or NestJS) and/or Python (Django or FastAPI) * Databases: PostgreSQL ... flexible PTO; standard startup benefits * Work Model: Hybrid or remote-friendly depending on ...

SmarterDx

Senior Software Engineer, Machine Learning

$190/hr

This role is fully remote within the US** What You'll Do * Build and scale machine-learning driven ... Strong proficiency in Python and SQL, with experience in machine learning libraries (Pytorch ...

OSI Engineering, Inc.

Senior AI Engineer

Cupertino, CA · On-site +1

$58 - $68/hr

Strong TypeScript development experience ( Python a plus) * Experience building AI-powered ... Startup or highly autonomous engineering experience preferred Education & Experience * Bachelor ...

Cypress HCM

Full Stack Developer

Atlanta, GA · On-site +1

$80K - $100K/yr

Remote from Atlanta, GA | In-office time (ATDC) will be available to you but isn't mandated ... Working in a highly autonomous environment at an early-stage startup with financial backing and ...

Hired Recruiters

Senior DevOps Engineer

Austin, TX · On-site +1

$128.90K - $165.50K/yr

Remote * Salary $150k - $200k * Seed Company * Skills: Ansible, Bash, Python, Terraform, Docker ... Experience working at a venture-backed early-stage startup * B.S., or M.S., in Computer Science or ...

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Remote Python Startup information

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How much do remote python startup jobs pay per hour?

As of May 30, 2026, the average hourly pay for remote python startup in the United States is $58.62, according to ZipRecruiter salary data. Most workers in this role earn between $48.32 and $66.59 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a Remote Python Developer at a startup, and why are they important?

To thrive as a Remote Python Developer at a startup, you need strong proficiency in Python programming, problem-solving abilities, and experience with web frameworks or APIs, often supported by a degree in computer science or related field. Familiarity with tools like Git, Docker, cloud platforms (AWS, GCP), and continuous integration systems is typically required. Self-motivation, adaptability, and excellent written communication are crucial soft skills for collaborating within distributed, fast-paced startup teams. These skills ensure you can deliver effective solutions, adapt to evolving priorities, and contribute positively to the startup's growth and remote culture.

How does working at a remote Python startup typically differ from larger, more established companies in terms of daily responsibilities and team collaboration?

At a remote Python startup, you can expect to wear multiple hats, often taking on responsibilities beyond strict coding, such as contributing to product decisions or helping shape development processes. Daily tasks are usually fast-paced and can shift rapidly as priorities change, requiring adaptability and strong self-motivation. Team collaboration often relies on digital tools like Slack, GitHub, and video meetings, fostering a culture of frequent communication and autonomy. This environment provides unique opportunities for rapid skill growth, direct impact on the company's success, and close collaboration with founders and cross-functional teams.

What is a Remote Python Startup?

A Remote Python Startup is a company or organization that is in its early stages of development and primarily operates remotely, with its team members working from different locations. The startup's core products or services are typically built using the Python programming language, which is known for its versatility and ease of use in web development, data science, automation, and more. Working at a remote Python startup often requires strong collaboration skills, self-motivation, and proficiency in Python and related technologies. Team members typically communicate through online tools and platforms to manage projects, build products, and solve problems together.

What is the difference between Remote Python Startup vs Remote Data Analyst?

AspectRemote Python StartupRemote Data Analyst
Required CredentialsPython programming skills, possibly some web frameworks, basic data handlingStatistical knowledge, data analysis tools, SQL, possibly some programming
Work EnvironmentTech startups, flexible remote settings, collaborative teamsBusiness or tech companies, remote or hybrid, focus on data insights
Industry UsageSoftware development, startups, tech industryFinance, marketing, healthcare, and other data-driven sectors

Remote Python Startup roles focus on software development using Python, often in startup environments, while Remote Data Analyst positions emphasize analyzing data to inform business decisions. Both roles require technical skills but differ in focus and industry application.

More about Remote Python Startup jobs
What cities are hiring for Remote Python Startup jobs? Cities with the most Remote Python Startup job openings:
What are the most commonly searched types of Python Startup jobs? The most popular types of Python Startup jobs are:
What states have the most Remote Python Startup jobs? States with the most job openings for Remote Python Startup jobs include:
What job categories do people searching Remote Python Startup jobs look for? The top searched job categories for Remote Python Startup jobs are:
Remote Python Startup jobs near you
Infographic showing various Remote Python Startup job openings in the United States as of May 2026, with employment types broken down into 74% Full Time, 23% Part Time, and 3% Contract. Highlights an 59% Physical, 26% Hybrid, and 15% Remote job distribution, with an average salary of $121,932 per year, or $58.6 per hour.

Senior ML Engineer

Career Renew

San Francisco, CA • Remote

$180K - $240K/yr

Full-time

Medical, PTO

Posted 26 days ago

Job description

Career Renew is recruiting for one of its clients a Senior Machine Learning Engineer - this is a fully remote role for US/Canada based candidates. Salary range: 180-240K USD plus benefits plus equity.
Since 2017, we’ve been on a mission to use AI to resolve as many conversations as possible while elevating human agents to do what they are uniquely good at.

We are looking for a Senior Machine Learning Engineer with 5+ years of experience to join our small but mighty ML team building production-grade AI voice agents used by enterprise customers like AAA and Fanatics. You're an applied AI engineer who thrives in startup environments, writes clean Python, and can ship LLM-powered systems that handle real, high-stakes conversations at scale — not just run experiments.


What will you be doing?

  • Leading the exploration and application of Large Language Models and Generative AI, venturing into new areas within these fields

  • Translating the latest research into high-performing systems and models that can be practically applied to enhance user experiences

  • Help set the team's strategic direction, cultivating an environment that encourages innovation and professional growth

  • Actively engaging in all aspects of development, from ideation and experimentation to implementation and deployment

  • Collaborating with various teams and product managers to develop and implement ML based solutions, ensuring performance optimization and alignment with broader business goals

Requirements:
5 - 10 years of experience in applied ML engineering, building production systems in Python with LLMs or NLP (Mandatory)
Experience building production systems in Python (Mandatory)
Familiarity with low-latency production ML systems (Mandatory)
Experience working at a high-growth startup (Mandatory)
Background in NLU, NLP, or conversational AI (Nice-to-have)
BS/MS/PhD in CS, ML, Mathematics, or closely related field with ML coursework (Mandatory)
Why you should join
  • Industry leader in Voice AI for customer service since 2017 — powering enterprise customers like AAA and Fanatics where 50%+ of callers get fully resolved by the bot with higher satisfaction scores than human agents.
  • $113M raised from top-tier investors including Stripes, Salesforce Ventures and Norwest — Series B closed in 2022 at $78M with strong backing from day one.
  • Work on genuinely cutting-edge AI problems — low latency inference, hallucination reduction, prompt injection guardrails and dynamic conversation design at the frontier of what's possible with LLMs today.
  • Small team means real ownership and real impact — every improvement you ship moves the needle for enterprise customers in high-stakes scenarios (think: someone stranded on the road calling AAA).
  • Remote-first with strong perks — flexible vacation, paid sabbatical after 5 years, comprehensive health benefits, wellness stipend and a tech/learning stipend for conferences, books and courses. Competitive salary ($180K–$230K) plus meaningful equity.