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Protein Purification Jobs (NOW HIRING)

ImmunEdge Inc.

$106 - $139/hr

You will own purification and analytical workstreams from initial material assessment through the delivery of high-quality protein and will collaborate with protein engineering, discovery biology ...

Aequor Inc

at MEDFORD, Massachusetts

Medford, MA · On-site

$36.75 - $46/hr

We are seeking a motivated Bench Scientist II to support protein purification, protein labeling, characterization, and related laboratory activities. The successful candidate will be responsible for ...

Aequor

Scientist

Cambridge, MA · On-site

$38.50 - $48.25/hr

Purify multiple recombinant proteins on a weekly basis using established protein purification methods. * Perform routine protein labeling and final characterization of target proteins, monoclonal ...

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$17

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How much do protein purification jobs pay per hour?

As of Sep 1, 2026, the average hourly pay for protein purification in the United States is $33.06, according to ZipRecruiter salary data. Most workers in this role earn between $21.63 and $40.87 per hour, depending on experience, location, and employer.

What is protein purification?

A Protein Purification job involves isolating and refining proteins from biological samples for research, pharmaceutical, or industrial applications. This process includes techniques such as chromatography, centrifugation, and filtration to achieve high purity and functionality. Professionals in this role work in laboratories, biotech firms, or pharmaceutical companies, ensuring quality control and optimizing purification protocols. Strong analytical skills and knowledge of biochemistry are essential for success in this field.

What does a typical day look like for someone working in protein purification?

A typical day in Protein Purification involves preparing and setting up purification systems, monitoring processes such as chromatography runs, analyzing sample purity, and maintaining detailed records of results. You’ll often collaborate with research scientists, quality control teams, and other lab staff to meet project deadlines and troubleshoot purification challenges. The work environment is usually a laboratory setting, where safety protocols and attention to detail are paramount. Successful professionals in this field balance hands-on technical tasks with regular communication to ensure the smooth progression of research or manufacturing projects.

What are the key skills and qualifications needed to thrive in protein purification, and why are they important?

Excelling in Protein Purification requires a solid background in biochemistry or a related life science, with hands-on experience in laboratory techniques such as chromatography, electrophoresis, and buffer preparation. Familiarity with tools like FPLC/HPLC systems, automated fraction collectors, and relevant quality control software is crucial. Attention to detail, problem-solving skills, and strong teamwork abilities distinguish top performers in this role. These skills are essential for ensuring the accuracy, purity, and reproducibility of protein samples in research or industrial environments.

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What states have the most Protein Purification jobs?

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Protein Purification jobs near you
Infographic showing various Protein Purification job openings in the United States as of August 2026, with employment types broken down into 81% Full Time, 15% Part Time, 3% Contract, and 1% Nights. Highlights an 88% Physical, 1% Hybrid, and 11% Remote job distribution, with an average salary of $68,765 per year, or $33.1 per hour.

Protein Expression Scientist - Temp

System One Holdings, LLC

Alameda, CA • On-site

$50 - $55/hr

Contractor, Temporary

Medical, Dental, Vision, Life, Retirement

Re-posted 25 days ago

Job description

Job Title: Protein Expression & Purification Scientist
Location: Alameda, CA
Type: 12 month contract
Compensation: $50-55/hour depending on qualifications
Contractor Work Model: Onsite
Hours: 40 hours/week
Overview
We are seeking a Protein Expression & Purification Scientist to support drug discovery programs through the design, expression, purification, and characterization of recombinant proteins. This hands-on laboratory role requires expertise in molecular biology, protein expression systems, and chromatographic purification methods, with opportunities to contribute across multiple research initiatives in a fast-paced discovery environment.
Responsibilities
  • Design, clone, and optimize expression constructs using molecular biology techniques, including PCR, primer design, sequence verification, and recombinant cloning strategies.
  • Execute recombinant protein expression workflows using baculovirus expression vector systems (BEVS) in insect cells and E. coli expression platforms.
  • Generate, amplify, and optimize baculovirus stocks to support protein production objectives.
  • Perform high-throughput small-scale expression screening to evaluate constructs, expression conditions, and protein yield.
  • Purify recombinant proteins using affinity, ion exchange, and size-exclusion chromatography techniques.
  • Optimize expression, culture, and purification parameters to improve protein yield, purity, and overall quality.
  • Conduct analytical characterization using SDS-PAGE, Western blotting, SEC, and related protein analysis methods.
  • Document experimental procedures, results, and observations in accordance with laboratory documentation standards.
  • Analyze data, troubleshoot technical challenges, and recommend improvements to workflows and experimental strategies.
  • Communicate scientific findings and project updates effectively with cross-functional team members.

Requirements
Required Qualifications
  • Bachelor's degree in Biochemistry, Molecular Biology, Structural Biology, or a related scientific discipline with 3+ years of relevant industry experience; or Master's degree with 1+ year of relevant industry experience.
  • Strong expertise in molecular biology techniques, including cloning, vector design, construct optimization, and sequence verification.
  • Experience with PCR, primer design, restriction enzyme-based cloning, and recombination-based cloning methods.
  • Demonstrated experience expressing recombinant proteins in BEVS/insect cell systems and E. coli expression systems.
  • Experience with high-throughput small-scale protein expression screening.
  • Proficiency in protein purification using chromatographic techniques, including affinity, ion exchange, and size-exclusion chromatography.
  • Experience performing protein analytical characterization using SDS-PAGE, Western blotting, SEC, and related techniques.
  • Strong analytical, troubleshooting, and problem-solving skills.
  • Ability to independently manage experiments while collaborating effectively within multidisciplinary teams.
  • Strong organizational, documentation, and scientific communication skills.

Preferred Qualifications
  • Experience with biophysical characterization techniques such as LC-MS, SPR, MST, SEC-MALS, nanoDSF, or mass photometry.
  • Experience with protein purification method development and process optimization.
  • Familiarity with electronic laboratory notebooks, including Benchling.
  • Experience supporting protein production activities within a drug discovery or biopharmaceutical research environment.

Benefits
System One, and its subsidiaries including Joulé, ALTA IT Services, and Mountain Ltd., are leaders in delivering outsourced services and workforce solutions across North America. We help clients get work done more efficiently and economically, without compromising quality. System One not only serves as a valued partner for our clients, but we offer eligible employees health and welfare benefits coverage options including medical, dental, vision, spending accounts, life insurance, voluntary plans, as well as participation in a 401(k) plan.
System One is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, age, national origin, disability, family care or medical leave status, genetic information, veteran status, marital status, or any other characteristic protected by applicable federal, state, or local law.
Ref: #568-Clinical
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About System One

Sourced by ZipRecruiter

System One helps employers get work done more efficiently and economically without compromising quality. Over our 35+ year history, we've helped connect thousands of talented people with innovative companies. The excitement of a perfect fit motivates us every single day.

Industry

Business consulting services and recruiting and staffing services

Company size

5,001 - 10,000 Employees

Headquarters location

Pittsburgh, PA, US

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