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Principal Programmer Analyst Jobs (NOW HIRING)

HOERBIGER Holding AG

Programmer Analyst

Waukegan, IL · Hybrid

$73K - $110K/yr

Programmer Analyst Country/Region: United States Job Location: Waukegan Required Travel (%): 5% ... OAuth2, server principals, token & key management, encryption, least-privilege access, and ...

HOERBIGER Holding AG

Programmer Analyst

Waukegan, IL · On-site

$73K - $110K/yr

Programmer Analyst Country/Region: United States Job Location: Waukegan Required Travel (%): 5% ... OAuth2, server principals, token & key management, encryption, least-privilege access, and ...

Le Moyne College

Programmer Analyst

Syracuse, NY · On-site

The Programmer/Analyst acts as a technical bridge between established systems and emerging ... Principal Duties and Essential Functions Job duties specific to this position: * Maintain and ...

Le Moyne College

Programmer Analyst

Syracuse, NY · On-site

The Programmer/Analyst acts as a technical bridge between established systems and emerging ... Principal Duties and Essential Functions Job duties specific to this position: * Maintain and ...

Zenius

Principal CICS Systems Programmer

Woodlawn, MD · On-site

Principal CICS Systems Programmer *** Selected candidate must be willing to work on-site in ... Provide in-depth analysis, debugging, and troubleshooting of CICS applications and systems. Support ...

Wood Rodgers

Principal Engineer

Roseville, CA · On-site

$126K - $158K/yr

Perform engineering analysis using company and industry methodologies and standards. * Provide work direction and training for engineering staff in exploration, sampling, laboratory testing, analysis ...

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Principal Programmer Analyst information

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How much do principal programmer analyst jobs pay per year?

As of Jun 5, 2026, the average yearly pay for principal programmer analyst in the United States is $122,589.00, according to ZipRecruiter salary data. Most workers in this role earn between $117,500.00 and $127,500.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a Principal Programmer Analyst, and why are they important?

To thrive as a Principal Programmer Analyst, you need advanced programming expertise, systems analysis experience, and often a degree in computer science or a related field. Familiarity with software development tools, enterprise databases, and methodologies like Agile or DevOps, along with relevant certifications such as PMP or AWS, is typically expected. Strong problem-solving, leadership, and communication skills help drive projects and mentor junior team members. These competencies ensure effective software solutions, streamlined project delivery, and successful team collaboration in complex technical environments.

What are some of the key challenges Principal Programmer Analysts face when leading cross-functional technical projects?

Principal Programmer Analysts often navigate complex challenges when overseeing cross-functional projects, such as balancing technical leadership with stakeholder management and ensuring clear communication between diverse teams. They are responsible for translating business requirements into technical solutions while aligning project goals with organizational strategy. Additionally, they frequently mentor junior developers and must stay updated with evolving technologies to guide best practices. Managing competing priorities and delivering solutions on time requires strong organizational and interpersonal skills.

What are Principal Programmer Analysts?

Principal Programmer Analysts are senior-level professionals who design, develop, and maintain complex software systems while also leading and mentoring development teams. They combine extensive programming expertise with strong analytical and problem-solving skills to create effective technical solutions that meet business needs. In addition to coding, they often oversee project architecture, provide technical guidance, and ensure software quality and performance. Their role typically involves collaborating with cross-functional teams, translating business requirements into technical specifications, and driving the implementation of best practices within the development process.

What is the difference between Principal Programmer Analyst vs Software Developer?

AspectPrincipal Programmer AnalystSoftware Developer
Required credentialsBachelor's degree in Computer Science or related field; often with experience in analysis and project managementBachelor's degree in Computer Science or related field; focus on coding and application development
Work environmentAnalyzes user needs, designs solutions, and oversees implementation within enterprise IT teamsDevelops, codes, and tests software applications primarily in development teams
Employer and industry usageUsed in corporate, government, and large organizations for complex systemsCommon across tech startups, software firms, and various industries for application creation

The Principal Programmer Analyst typically combines technical expertise with analytical skills to design and oversee software solutions, often taking on a leadership role in projects. In contrast, Software Developers focus primarily on coding and building applications. Both roles require a strong foundation in programming, but the Principal Programmer Analyst's responsibilities extend into analysis and project oversight, making it a more senior and multifaceted position.

More about Principal Programmer Analyst jobs
What cities are hiring for Principal Programmer Analyst jobs? Cities with the most Principal Programmer Analyst job openings:
What job categories do people searching Principal Programmer Analyst jobs look for? The top searched job categories for Principal Programmer Analyst jobs are:
Principal Programmer Analyst jobs near you
Infographic showing various Principal Programmer Analyst job openings in the United States as of May 2026, with employment types broken down into 93% Full Time, 6% Part Time, and 1% Temporary. Highlights an 94% Physical, 2% Hybrid, and 4% Remote job distribution, with an average salary of $122,589 per year, or $58.9 per hour.

Senior Principal Programmer

Braveheart Bio

San Francisco, CA • On-site, Remote

$250K - $295K/yr

Full-time

Posted 22 days ago

Job description

About us:
Braveheart Bio is a Bay Area-based biopharmaceutical company pioneering best-in-class therapies for cardiovascular disease. Our lead program is a next-generation myosin inhibitor, licensed from Hengrui Pharma, being developed to transform the treatment of hypertrophic cardiomyopathy (HCM)-the most common inherited cardiac disease.
Currently in Phase 3 clinical development in China for the more common obstructive form of HCM, our candidate has demonstrated a compelling clinical profile that may position it as a best-in-class therapy with meaningful differentiation.
With a proven leadership team, a strong financial foundation, and a high-value late-stage asset, Braveheart Bio represents an outstanding opportunity for ambitious, mission-driven professionals to make a tangible impact in a high-profile and rapidly evolving therapeutic area.
The role:
The Senior Principal Programmer will report into the VP, Biometrics and provide strategic and technical leadership for clinical programming activities across clinical development programs. This individual will oversee CRO programming deliverables, support global regulatory submissions, contribute to ongoing study monitoring, and collaborate closely with Biostatistics, Data Management, Clinical Operations, Regulatory, and external vendors to ensure high-quality, compliant, and timely delivery of clinical data outputs.
Key responsibilities:
  • Oversee CRO programming activities, including SDTM, ADaM, TFLs, define.xml, reviewer's guides, and other clinical study or submission deliverables.
  • Review CRO programming plans, specifications, datasets, outputs, QC documentation, issue logs, and submission packages.
  • Ensure programming deliverables are accurate, traceable, reproducible, and compliant with CDISC standards and FDA/EMA expectations.
  • Serve as the internal programming lead for FDA, EMA, and other regulatory submissions, including support for health authority questions and ad hoc analyses.
  • Support ongoing study monitoring by reviewing safety, efficacy, DMC, interim analysis, patient profile, and data review outputs prepared by the CRO.
  • Collaborate with Data Management to support data cleaning, external data review, reconciliation, database lock, and data quality activities.
  • Work closely with Biostatistics, Clinical Operations, Regulatory, Safety, Data Management, CROs, vendors, and external partners to align timelines, deliverables, standards, and responsibilities.
  • Coordinate with alliance or development partners on programming-related deliverables, review comments, issue resolution, and submission-readiness activities.
  • Track CRO performance, identify programming risks, resolve issues, and ensure timely delivery of high-quality outputs.
  • Provide programming input into protocols, SAPs, data standards, TFL shells, DMC charters, submission plans, and regulatory response strategies.

Required experience & skills:
  • At least 10 years of experience in clinical statistical programming in biotechnology/ pharmaceutical industry
  • Strong expertise in SAS, CDISC SDTM/ADaM standards, TFLs, define.xml, SDRG, ADRG, and regulatory submission requirements
  • Experience overseeing CRO programming deliverables and supporting FDA/EMA submissions
  • Strong expertise in clinical trials, data management processes, database lock, interim analyses, DMC support, and regulatory responses
  • Strong written and verbal communication skills with a collaborative, team-oriented approach
  • Ability to thrive in a fast-paced, dynamic environment and remain comfortable with change and ambiguity
  • Flexible, proactive, and comfortable operating with lean internal resources and contributing hands-on as needed

Preferred experience & skills:
  • Prior experience serving as programming lead or submission programming lead
  • Experience overseeing multiple studies or programs in parallel
  • Experience working with global CROs, vendors, and external development partners
  • Ability to read/communicate in Chinese is helpful

Base Salary Range: $250K - $295K
This role is eligible for a competitive total rewards package, including an annual bonus, equity, and a comprehensive benefits offering.
We are an equal opportunity employer.
We are committed to inclusion and diversity, and we do not discriminate on the basis of race, gender, religion, gender, sexual orientation, age, color, marital status, veteran status, disability status, national origin, or any characteristic protected under applicable law.
Braveheart participates in the federal E-Verify program to confirm employment authorization for all new hires.
To learn more about E-Verify please review this poster.

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