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Braveheart Bio

Senior Principal Programmer

$250K - $295K/yr

The Senior Principal Programmer will report into the VP, Biometrics and provide strategic and technical leadership for clinical programming activities across clinical development programs. This ...

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Principal CICS Systems Programmer *** Selected candidate must be willing to work on-site in Woodlawn, MD 5 days a week. Key Required Skills: CICS v6.x System Programming, COTS tools administration ...

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Infographic showing various Principal Programmer job openings in the United States as of June 2026, with employment types broken down into 99% Full Time, and 1% Contract. Highlights an 93% Physical, 2% Hybrid, and 5% Remote job distribution, with an average salary of $122,589 per year, or $58.9 per hour.

Senior Principal Programmer

Braveheart Bio

Remote

$250K - $295K/yr

Other

Posted 9 days ago

Job description

About us:
Braveheart Bio is a clinical-stage biopharmaceutical company focused on developing therapies for patients with hypertrophic cardiomyopathy (HCM) and other serious cardiovascular diseases. Our lead product candidate, BHB-1893, is a next-generation oral small-molecule cardiac myosin inhibitor (CMI) being developed for the treatment of obstructive HCM (oHCM) and non-obstructive HCM (nHCM). Braveheart's goal is to improve the treatment options for these patients by enhancing speed of onset, depth of gradient response, systolic safety, reversibility and reducing prescribing complexity.
With a proven leadership team, a strong financial foundation, and a high-value late-stage asset, Braveheart Bio represents an outstanding opportunity for ambitious, mission-driven professionals to make a tangible impact in a high-profile and rapidly evolving therapeutic area.
The role:
The Senior Principal Programmer will report into the VP, Biometrics and provide strategic and technical leadership for clinical programming activities across clinical development programs. This individual will oversee CRO programming deliverables, support global regulatory submissions, contribute to ongoing study monitoring, and collaborate closely with Biostatistics, Data Management, Clinical Operations, Regulatory, and external vendors to ensure high-quality, compliant, and timely delivery of clinical data outputs.
Key responsibilities:
  • Oversee CRO programming activities, including SDTM, ADaM, TFLs, define.xml, reviewer's guides, and other clinical study or submission deliverables.
  • Review CRO programming plans, specifications, datasets, outputs, QC documentation, issue logs, and submission packages.
  • Ensure programming deliverables are accurate, traceable, reproducible, and compliant with CDISC standards and FDA/EMA expectations.
  • Serve as the internal programming lead for FDA, EMA, and other regulatory submissions, including support for health authority questions and ad hoc analyses.
  • Support ongoing study monitoring by reviewing safety, efficacy, DMC, interim analysis, patient profile, and data review outputs prepared by the CRO.
  • Collaborate with Data Management to support data cleaning, external data review, reconciliation, database lock, and data quality activities.
  • Work closely with Biostatistics, Clinical Operations, Regulatory, Safety, Data Management, CROs, vendors, and external partners to align timelines, deliverables, standards, and responsibilities.
  • Coordinate with alliance or development partners on programming-related deliverables, review comments, issue resolution, and submission-readiness activities.
  • Track CRO performance, identify programming risks, resolve issues, and ensure timely delivery of high-quality outputs.
  • Provide programming input into protocols, SAPs, data standards, TFL shells, DMC charters, submission plans, and regulatory response strategies.
Required experience & skills:
  • At least 10 years of experience in clinical statistical programming in biotechnology/ pharmaceutical industry
  • Strong expertise in SAS, CDISC SDTM/ADaM standards, TFLs, define.xml, SDRG, ADRG, and regulatory submission requirements
  • Experience overseeing CRO programming deliverables and supporting FDA/EMA submissions
  • Strong expertise in clinical trials, data management processes, database lock, interim analyses, DMC support, and regulatory responses
  • Strong written and verbal communication skills with a collaborative, team-oriented approach
  • Ability to thrive in a fast-paced, dynamic environment and remain comfortable with change and ambiguity
  • Flexible, proactive, and comfortable operating with lean internal resources and contributing hands-on as needed
Preferred experience & skills:
  • Prior experience serving as programming lead or submission programming lead
  • Experience overseeing multiple studies or programs in parallel
  • Experience working with global CROs, vendors, and external development partners
  • Ability to read/communicate in Chinese is helpful

Base Salary Range: $250K - $295K
This role is eligible for a competitive total rewards package, including an annual bonus, equity, and a comprehensive benefits offering.
We are an equal opportunity employer.
We are committed to inclusion and diversity, and we do not discriminate on the basis of race, gender, religion, gender, sexual orientation, age, color, marital status, veteran status, disability status, national origin, or any characteristic protected under applicable law.
Braveheart participates in the federal E-Verify program to confirm employment authorization for all new hires.
To learn more about E-Verify please review this poster.

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