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Principal Clinical Scientist Jobs (NOW HIRING)

Danaher

Principal Clinical Scientist

Miami, FL · On-site +1

Principal Clinical Scientist . This role is responsible for clinical trial strategies within the US and EU regions for Danaher Diagnostics. This role will specifically support Beckman Coulter ...

Danaher

Principal Clinical Scientist

Chaska, MN · On-site

$120K - $165K/yr

Principal Clinical Scientist . This role is responsible for clinical trial strategies within the US and EU regions for Danaher Diagnostics. This role will specifically support Beckman Coulter ...

Danaher

Principal Clinical Scientist

Chaska, MN · On-site +1

Principal Clinical Scientist . This role is responsible for clinical trial strategies within the US and EU regions for Danaher Diagnostics. This role will specifically support Beckman Coulter ...

Jobtailor

NY · On-site

$180 - $260/hr

Act as a scientific and clinical liaison with regulatory bodies and external sites * Partner cross-functionally with R&D, Regulatory, Medical Affairs, Quality, and Commercial teams * Author and ...

New

Natera

OR

We are seeking a Principal Clinical Scientist / Associate Director of Real-World Evidence & Epidemiology to drive observational evidence strategy for our Early Cancer Detection (ECD) portfolio.

Abbott

Principal Clinical Specialist

Austin, TX

Principal Clinical Specialist About Abbott Abbott is a global healthcare leader, creating breakthrough science to improve people's health. We're always looking towards the future, anticipating ...

Abbott

Principal Clinical Specialist

Austin, TX · On-site

Principal Clinical Specialist About Abbott Abbott is a global healthcare leader, creating breakthrough science to improve people's health. We're always looking towards the future, anticipating ...

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Principal Clinical Scientist information

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$68.5K

$144K

$190.5K

How much do principal clinical scientist jobs pay per year?

As of Aug 8, 2026, the average yearly pay for principal clinical scientist in the United States is $144,009.00, according to ZipRecruiter salary data. Most workers in this role earn between $117,500.00 and $169,000.00 per year, depending on experience, location, and employer.

What challenges do principal clinical scientists face and how do they address them?

Principal Clinical Scientists often encounter challenges such as managing complex clinical trials with diverse teams spread across multiple locations, ensuring adherence to strict regulatory standards, and interpreting large volumes of scientific data. To address these challenges, professionals rely on robust project management skills, clear communication with cross-functional stakeholders, and a strong understanding of both clinical and regulatory processes. They also stay up-to-date with evolving industry standards and best practices to ensure successful trial execution. These efforts are essential for maintaining high-quality research outputs and achieving trial objectives on time and within budget.

What does a principal clinical scientist do?

A principal clinical scientist leads research and development efforts in clinical settings, overseeing the design, implementation, and analysis of clinical trials. They collaborate with healthcare professionals, ensure compliance with regulatory standards, and utilize scientific tools and data to improve patient outcomes and medical treatments.

What skills and qualifications are needed to be a principal clinical scientist?

To thrive as a Principal Clinical Scientist, you need deep expertise in clinical research, data analysis, regulatory requirements, and typically hold an advanced degree (PhD, PharmD, or equivalent) in a life sciences field. Familiarity with clinical trial management systems (CTMS), regulatory submission platforms, and certifications such as GCP (Good Clinical Practice) are highly valued. Exceptional leadership, communication, and problem-solving skills help set standout professionals apart in this role. These abilities are crucial for successfully leading scientific teams, ensuring regulatory compliance, and translating complex scientific data into actionable outcomes.

What is a principal clinical scientist?

A Principal Clinical Scientist is a senior-level professional who leads scientific research and clinical studies to support the development of medical treatments and technologies. They oversee experimental design, data analysis, and regulatory compliance while collaborating with multidisciplinary teams. Their role often involves interpreting clinical data, ensuring patient safety, and contributing to strategic decision-making in healthcare or pharmaceutical settings.

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What are the most commonly searched types of Principal Clinical Scientist jobs? The most popular types of Principal Clinical Scientist jobs are:
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Principal Clinical Scientist jobs near you
Infographic showing various Principal Clinical Scientist job openings in the United States as of August 2026, with employment types broken down into 3% As Needed, 71% Full Time, 18% Part Time, and 8% Contract. Highlights an 95% Physical, 1% Hybrid, and 4% Remote job distribution, with an average salary of $144,009 per year, or $69.2 per hour.

Senior / Principal Clinical Scientist, Clinical Development

Immunome, Inc.

Bothell, WA

Full-time

Posted 22 days ago

Job description

Position Overview

We are seeking a highly motivated and experienced Clinical Scientist to join our team. The Senior / Principal Clinical Scientist, Clinical Development will play a critical role in the design, execution, and interpretation of multiple clinical trials for our oncology drug candidates. This individual will work closely with cross-functional teams, including clinical operations, regulatory affairs, and research and development, to ensure the successful progression of multiple clinical programs. 

Responsibilities

  • Oversee the execution of clinical trials and ensure scientific and regulatory rigor. 
  • Design and develop multiple clinical trial protocols, informed consent forms, and other study-related documents. 
  • Collaborate with principal investigators, key opinion leaders, and clinical trial sites to ensure robust study design and execution. Serve as Lead Clinical Scientist for multiple trials. 
  • Conduct activities related to data generation and validation, including CRF design and clinical data review/query resolution. 
  • Contribute to the preparation of clinical study reports, regulatory submissions, and publications. 
  • Review development of site and CRA training materials and presentation at SIV and Investigator meetings and support on Study committee (e.g., DMC) activities. 
  • Perform site-facing activities such as training and responding to clinical questions. 
  • Participate in the strategic development of clinical development plans and timelines. 
  • Present clinical trial data and findings to internal and external stakeholders, including scientific advisory boards and regulatory agencies. 
  • Mentor and develop junior team members with potential to manage direct reports. 

Qualifications

  • PhD, MD, PharmD, MS, or equivalent degree in life sciences. 
  • A minimum of 2 years of experience in clinical science, clinical research, or equivalent; clinical development experience is required, biopharmaceutical/biotechnology industry and oncology experience preferred. 
  • Strong leadership, project management, and communication skills. 
  • Travel may be required. 

Knowledge and Skills

  • Extensive experience in drug development process, study design, clinical operations. 
  • Extensive experience in clinical trial data analysis software and tools. 
  • Strong knowledge and skills to support program specific data review, trend identification, and data interpretation. 
  • Strong understanding of regulatory requirements and guidelines for clinical trials (e.g., GCP, ICH, FDA). 
  • Excellent analytical, organizational, and communication skills. 
  • Ability to work effectively in a fast-paced, collaborative environment. 
  • Strong problem-solving skills and attention to detail. 

WA State Range: Senior Clinical Scientist, Clinical Development - $145,823 - $182,019 

WA State Range: Principal Clinical Scientist, Clinical Development - $169,883 - $200,742 

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