Preclinical Research Engineer Jobs (NOW HIRING)

THE ROLE

We are seeking an experienced Staff Scientist with expertise in formulation development to support our small molecule pipeline. They will ensure that fit for purpose formulations are used for nonclinical in vivo studies. They will design, execute, manage, and analyze studies to develop and deliver formulations that support nonclinical DMPK, pharmacology, and toxicology studies. They may also support the development of clinical formulations.

This position reports to the Director of Pharmaceutical Development is an onsite position requiring in-person collaboration with cross-functional teams.

Responsibilities

• Develop early formulation strategies and serve as an SME to deliver fit-for-purpose formulations supporting PK, PD, efficacy, and safety preclinical studies through discovery to candidate selection across research programs.
• Design, manage, and execute early formulation screening studies to enable high-quality in vivo data, including solubility assessments, excipient compatibility, enabling approaches, and stability.
• Implement early formulation development and preparation workflows, tools, templates, and best practices internally and in partnership with CDMOs/CROs to support preclinical studies.
• Represent early formulation on cross-functional research teams, presenting data and recommendations to ensure aligned and timely support.
• Author and review technical documents to support early formulation activities and preclinical studies, including development reports and study protocols.
• Manage multiple priorities in a fast-paced, dynamic environment and enact quick problem solving to ensure on-time supply of formulations to support preclinical studies across programs.

Qualifications

• A PhD, MS, or BS in Pharmaceutics, Pharmaceutical Sciences, Chemical Engineering, or a related field with a minimum of 6 years, 10 years, or 12 years, respectively, of relevant industry experience in small molecule formulation development.
• Demonstrated success delivering formulation strategies to support preclinical research studies using data-driven, riskbased strategies.
• Experience in small molecule formulation development across multiple routes of administration, including powders, solid dosage forms, solutions, suspensions, nanoparticles, and lipidbased systems.
• Hands-on experience with analytical techniques to support small molecule formulation development, including UPLC/HPLC and solid-state characterization techniques (e.g., particle size analysis, DSC, DVS, PLM, and XRPD).
• Working knowledge and practical application of current industry and compendial standards and regulatory authority guidance and expectations, including ICH, FDA, MHRA, and EMA guidelines and USP-NF, Ph. Eur, BP, and JP compendia.
• Ability to manage and collaborate with external partners, including consultants and CDMOs/CROs.
• Excellent interpersonal and communication skills (written and oral) with the ability to effectively prepare high-quality technical documentation and concisely present data to peers, management, and external groups.
• Exhibited strong organizational and critical thinking skills with an attention to detail and data integrity enabling sound, technically driven decision making.
• Able to travel domestically and internationally as needed, up to 20% of the time.

The anticipated salary range for candidates who will work in South San Francisco, CA is $160,000 - $180,000. Individual pay may vary based on additional factors, including, and without limitation, job-related skills, experience, work location and relevant education or training. Septerna's compensation package also includes benefits, stock options, and annual target bonus for full-time positions.

We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. 

Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.