Preclinical Research Engineer Jobs (NOW HIRING)

At Regeneron, we use science and innovation to develop life-changing medicines for people with serious diseases. We are seeking a Senior Associate Scientist to join our discovery research team at Regeneron Cell Medicines. In this role, you will perform immunological functional assays to analyze genetically engineered human primary T cells (CAR-T or TCR T cells), supporting both early discovery programs and late-stage development programs' nonclinical studies that inform regulatory submissions.

This position offers the opportunity to work hands-on in a fast-paced laboratory environment, contributing to the preclinical research and development of next-generation cell therapies.

• Shift Requirements: Full-time, standard business hours, with flexibility to support a fast-paced research environment
• Location: On-site laboratory setting
• Flexibility & travel: Minimal to no travel; consistent on-site presence required to support ongoing experiments and project timelines

• Contribute to preclinical research and development of CAR/TCR T cell therapies in solid tumor indications
• Characterize genetically modified primary human T cells via immunophenotyping using multi-color flow cytometry and molecular assays (PCR, library preps for NGS, RNA-Seq)
• Develop and perform immunological functional assays to assess immune cell activation, anti-tumor cytotoxicity, proliferation, and cytokine secretion to evaluate the efficacy of CAR and TCR-based T-cell therapeutics
• Design experiments independently and contribute to overall project direction
• Maintain an electronic lab notebook and thoroughly document experiment results
• Review and present research data to the functional team

• This is a hands-on, on-site laboratory role in a fast-paced research setting. The role requires the ability to perform bench work involving fine motor tasks (e.g., pipetting, cell culture manipulation), extended periods of standing, and use of standard laboratory equipment.
• Flexibility to adapt quickly to new research areas, shifting priorities, and evolving experimental techniques is required.

• BS/MS in immunology, cell biology, or a related field, with 3+ years of relevant experience
• Experience working in a biotech/pharmaceutical industry
• Strong understanding of immunology and cancer biology
• Extensive experience in primary human immune cell isolation techniques and mammalian cell culture, including culture of primary human T lymphocytes
• Demonstrated experience with in-vitro immunological studies and development of functional T cell assays using techniques such as multi-color flow cytometry, ELISA, and cytotoxicity assays

• Experience with gene delivery into T cells or tumor cells using lentiviral vector transduction, CRISPR/Cas9 editing, and mRNA electroporation
• Experience with standard molecular biology techniques, including PCR, qPCR, Westerns, and library preps for NGS/RNA-Seq

• Student Loan Paydown program & Tuition Reimbursement
• Family Care Benefits
• Relocation Assistance
• Inclusion, Culture and Well-Being programs (including physical & mental health)

Does this sound like you? Apply now to take your first step towards living the Regeneron Way! We are committed to building a workplace with an inclusive culture. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.

Where necessary, we disclose salary ranges for roles in all countries in which we operate. The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience. In some countries, collective bargaining agreements (CBAs) may apply and influence certain elements of pay or benefits. Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role: annual bonuses or other incentive plans, equity awards, pension or retirement benefits, 401(k) company match, health and wellness programs, fitness centers, insurance benefits (e.g. medical, dental, vision, life and disability), paid time off, and family support benefits. For additional information about Regeneron benefits in the U.S., please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/. For other locations, additional information will be provided during the recruitment process. If you have any questions, please speak with your recruiter.

Please be advised that at Regeneron, we believe we do our best work when we are together. For that reason, many roles are required to be performed onsite. Please speak with your recruiter and hiring manager for more information about onsite expectations for your role and location.

As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based. The purpose of such checks is to verify certain information prior to the commencement of employment such as identity, right to work and educational qualifications.

For jobs in Canada: this posting is for an existing position.

Salary Range (annually)