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Pbpk Jobs (NOW HIRING)

Iambic Therapeutics, Inc

$164K - $245K/yr

Apply quantitative approaches (e.g., PBPK, population PK, exposure-response modeling) to inform dose selection and DDI risk assessment, with working knowledge of relevant software (e.g., SimCyp ...

Iambic Therapeutics, Inc.

Apply quantitative approaches (e.g., PBPK, population PK, exposure-response modeling) to inform dose selection and DDI risk assessment, with working knowledge of relevant software (e.g., SimCyp ...

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How much do pbpk jobs pay per year?

As of Sep 13, 2026, the average yearly pay for pbpk in the United States is $59,022.00, according to ZipRecruiter salary data. Most workers in this role earn between $49,000.00 and $66,500.00 per year, depending on experience, location, and employer.

What is a PBPK?

A PBPK (Physiologically Based Pharmacokinetic) job typically involves developing and applying mathematical models to predict the absorption, distribution, metabolism, and excretion (ADME) of drugs in the human body. Professionals in this field use PBPK modeling to support drug development, regulatory submissions, and dose optimization. They work with pharmacokinetics, computational modeling software, and biological data to improve drug safety and efficacy.

What does a PBPK modeler do?

As a PBPK Modeler, your daily tasks often include developing and validating pharmacokinetic models, analyzing clinical or preclinical data, and preparing simulation reports for regulatory submissions. You will collaborate closely with pharmacologists, clinical researchers, and other scientists to design experiments and interpret complex data. Communication with cross-functional teams is common, as your modeling insights inform critical decisions in drug development. Staying current with scientific literature and best practices is also essential to ensure high-quality results and innovative solutions.

What are the key skills and qualifications needed for a PBPK position?

To thrive as a PBPK (Physiologically Based Pharmacokinetic) Modeler, you need a solid background in pharmacokinetics, mathematical modeling, and a degree in pharmacology, pharmaceutical sciences, or a related field. Familiarity with modeling software such as Simcyp, GastroPlus, or PK-Sim, as well as experience with programming languages like R or MATLAB, is highly valuable. Critical thinking, attention to detail, and clear communication are essential soft skills for interpreting data and collaborating with cross-functional teams. These skills ensure accurate model development, effective data interpretation, and strong contributions to drug development projects.

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Pbpk jobs near you
Infographic showing various Pbpk job openings in the United States as of September 2026, with employment types broken down into 99% Full Time, and 1% Part Time. Highlights an 76% Physical, 11% Hybrid, and 13% Remote job distribution, with an average salary of $59,022 per year, or $28.4 per hour.

Associate Director, Quantitative Pharmacology

Wilmington, DE • On-site

Incyte Corporation
Pharmaceutical and Medicine Manufacturing • 501 - 1,000 employees
Learn more about Incyte Corporationexternal

Other

Re-posted 23 days ago

Job description

Overview

A global biopharmaceutical company on a mission to Solve On, Incyte follows science to find solutions for patients with unmet medical needs. Through the discovery, development, and commercialization of proprietary therapeutics, Incyte has established a portfolio of first-in-class medicines for patients and a strong pipeline of products in Hematology, Oncology and Inflammation and Autoimmunity

Headquartered in Wilmington, Delaware, Incyte has operations in North America, Europe, and Asia.

Job Summary (Primary function)
The Research Investigator, Pharmacokinetics is responsible for performing PK/PD analysis, population PK/PD analysis, and PBPK for Biologics and small molecules in the clinical pharmacokinetics group.

Essential Functions of the Job (Key responsibilities)

  • Present work at internal and external scientific meetings and publish manuscripts in peer-reviewed journals.
  • Work with clinician, biostatistician, and data manager to provide deliverables on time.
  • Represent clinical pharmacokinetics on clinical project teams.
  • Conduct model based simulations using PBPK method to design studies that yield high value PK/PD information for future critical decisions.
  • Perform PK/PD analyses, pop PK/PD analyses, interpret and report data to clinical teams and management in a timely manner.
  • Advise clinical teams on PK and PK/PD study design.

Qualifications (Minimal acceptable level of education, work experience, and competency)

  • Ability to work both independently and collaboratively with diverse teams.
  • Excellent written and verbal communication skills.
  • Experience with writing reports for regulatory submissions is desired.
  • Experience with a range of software packages, such as but not limited to: WinNonlin, NONMEM, R, SimCyp and GastroPlus.
  • Experience in large molecule development is highly preferable.
  • Experience in analyzing clinical pharmacology data.
  • Experience in clinical PK, population PK analysis, and PBPK modeling.
  • Advanced degree (e.g., Ph.D., Master's) in Pharmacokinetics, Pharmacometrics, Pharmacology, Engineering, Statistics, or related fields, or equivalent experience.

Disclaimer: The above statements are intended to describe the general nature and level of work performed by employees assigned to this job. They are not intended to be an exhaustive list of all duties, responsibilities, and qualifications. Management reserves the right to change or modify such duties as required.

Incyte Corporation is committed to creating a diverse environment and is proud to be an equal opportunity employer.

We Respect Your Privacy

Learn more at: http://www.incyte.com/privacy-policy

The Incyte hiring organization processes your personal data to manage your job application in order to enter into an employment relationship with you if you are the successful candidate.
During the process, you may be asked to respond to questions that will screen out your application if you do not meet certain objective criteria required by the job. You can learn more about this process here.

You may have the right to access, delete, restrict, edit, move, or object to the use of your personal data. You may also have a right to report concerns to the authority responsible for data privacy in the country where the position is based or where you live or work.

You can learn more about Incyte's data protection practices here. By accessing this link you can learn about the types of personal data we collect, how we use it, whether collection and processing is optional, sources of the personal data we process, how it is shared, where it is stored or transferred to, how long we keep it, and contact information for Incyte, Incyte's data protection officer, and your supervisory authority (if applicable).

Please contact privacy@incyte.com if you have any questions or concerns or would like to exercise your rights.

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