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Mayo Clinic's Department of Clinical Genomics, in collaboration with aligned departments and programs, seeks exceptional physicians and scientists, experts in the rapidly evolving field of genome editing and therapeutic delivery, to drive innovation at the intersection of discovery, translational, clinical research, and clinical practice to join our new and rapidly evolving Program in Precision Genomics: Interventional Therapeutics (PG-IT). 

The PG-IT program at Mayo Clinic is a groundbreaking new initiative of highly innovative and creative scientists and physicians working collaboratively to advance next-generation molecular therapies by delivering genetically targeted treatments in vivo. We are building an accomplished team of leaders including scientists driving innovation in genome editing and physicians who can deliver customized new and novel genetic therapies to the patients we serve. We are seeking candidates who excel in collaborative, team-oriented environments and demonstrate a strong commitment to advancing genomic medicine for improved patient outcomes. Qualified candidates joining the PG-IT program will collectively possess expertise in rare and complex disease genetics and genomics, clinical-grade genomic sequencing, multi-omic investigations, interventional human genetics, functional genomics, innovative molecular therapeutics, and human interventions and clinical trials, including single patient expanded access investigational new drug (IND) development processes. These candidates will join our efforts to develop a comprehensive institutional program that unites laboratory discovery, clinical genomics, informatics, and precision therapeutics, thereby delivering transformative advancements for patients affected by genetic and genomic disorders, including rare, inherited and complex disorders and diseases.

The PG-IT program will build on tremendous strengths at Mayo Clinic including: 

• The Mayo Clinic Artificial Intelligence (AI) Program, driving the development of AI-based drug discovery, predictive models, large language models (LLMs), and AI agents within research and implemented into the Mayo Clinic clinical practice, powered by unparalleled partnerships and compute capabilities (NVIDIA SuperPOD DGX B200).
• Mayo Clinic Platform (MCP; www.mayoclinicplatform.org), the world's largest distributed federated healthcare data network with cloud-based storage of the fully digitized longitudinal patient records (including fully digitized radiographic images and pathology slide images, and sophisticated laboratory diagnostics) and associated research data and biospecimens from >50M patients at Mayo Clinic and MCP partners worldwide.
• Exceptional research and clinical programs, research infrastructure, shared research resources, and education and training programs to facilitate research in basic and clinical genomics and molecular engineering to precisely target genetic drivers of rare and complex conditions. 
• A robust clinical research and clinical trials infrastructure that currently supports the delivery of the nation's largest number of clinical trials to the patients we serve, including new and novel and "first in human" therapies, including cellular, biologic, and genetic therapies.
• Mayo Clinic's unique collaborative ecosystem, which includes an integrated clinical practice, world-class research platforms, and advanced infrastructure for gene and cell-based therapeutic development.

Our goals for the Mayo Clinic PG-IT program include in vivo human gene editing for rare and inherited genetic disorders and complex human diseases, the acceleration of drug repurposing for genetically targeted indications, and identifying the most promising novel gene-editing interventions to benefit patients. This will help accelerate discovery and apply cutting-edge innovations in real-world settings. Areas of opportunity span therapeutic development, CRISPR- and RNA-based interventions, genome engineering, molecular diagnostics, novel mechanisms and modes of delivery of genetic therapies in vivo, and the deployment of genomics-enabled clinical care pathways for rare, inherited, and complex conditions. 

Successful candidates will lead, design, and implement innovative genomic and translational approaches that improve patient outcomes while driving forward to the next generation of therapeutic and diagnostic discovery. These roles offer the opportunity to collaborate across Mayo Clinic's extensive research and clinical networks, including partnerships with the Mayo Clinic Laboratories, the Advanced Diagnostics Laboratory, extensive biopharma partnerships and collaborations, and enterprise-wide precision medicine initiatives. Faculty will contribute to the development and integration of emerging genomic technologies into clinical and therapeutic pipelines, helping to shape programs that influence local, national, and global practice in genomic medicine. As the PG-IT Program builds it will gain SAGE (Standards for Advanced Gene Editing) certification for the customized delivery of human genetic interventions.

Mayo Clinic's values of teamwork, collaboration, and patient-centered care are foundational to deliver integrated research, medical, and surgical care for individuals with complex genetic and genomic conditions. Faculty members will receive academic appointments (Assistant, Associate, Full Professor and Consultant) within the Mayo Clinic College of Medicine and Science commensurate with experience, scholarly contributions, and leadership in clinical, research, or translational domains. Mayo Clinic is committed to supporting the long-term success of faculty through robust research infrastructure, interdisciplinary mentorship, and a culture that values innovation, scientific excellence, and transformative patient impact.
We are enthusiastic about the potential to work with visionary leaders in the field and look forward to the opportunity to make significant strides in genomic medicine together.

The Department of Clinical Genomics
The Department of Clinical Genomics at Mayo Clinic is a national leader in integrating advanced genomic science with patientcentered clinical care. Our mission is to individualize medicine through the development and application of cuttingedge genomic technologies that enable the prediction, prevention, diagnosis, and treatment of both rare and common genetic conditions. By generating deep insights into each patient's genomic architecture, our teams drive innovative care strategies that improve outcomes and shape the future of precision medicine.

Clinical Genomics supports a broad spectrum of services, including comprehensive family history assessments, risk evaluations for hereditary conditions, and wholeexome, wholegenome, and multiomic testing for complex and rare disorders. These programs are tightly integrated with enterprisewide research and clinical resources, providing faculty with unparalleled access to worldclass platforms in sequencing, functional genomics, bioinformatics, and emerging therapeutic modalities.
Our department operates through a highly collaborative, multidisciplinary model, bringing together medical geneticists, PhD scientists, certified genetic counselors, nurses, and allied specialists across Mayo Clinic's practice and research environment. This seamless integration enables faculty to evaluate virtually any genetic condition, coordinate advanced diagnostic workflows, and partner with teams across the institution to translate discovery into meaningful clinical impact.

For faculty, Clinical Genomics is an enterprise department spanning the three Mayo Clinic sites of Rochester, Florida, and Arizona, and offers a dynamic and supportive environment in which to build innovative research programs, engage in transformative clinical initiatives, and contribute to Mayo Clinic's enterprise commitment to advancing genomic medicine. Faculty benefit from strong institutional support, access to robust research infrastructure, the opportunity to collaborate across multiple campuses, and the ability to contribute to initiatives that influence care on a national and global scale.

Mayo Clinic
For over 160 years, the mission of Mayo Clinic has been to inspire hope and to promote health and healing through the integration of clinical practice, research, and education on behalf of the patients, communities, and learners we serve from across the nation and the world.  Each of Mayo Clinic's three Destination Medical Center (DMC) campuses in the United States are fully engaged in clinical practice, innovative research, and education and training.  These three campuses - referred to as the Mayo Clinic enterprise - include Rochester, Minnesota (MCR); Jacksonville, Florida (MCF); and Phoenix and Scottsdale, Arizona (MCA).  In addition, Mayo Clinic fully owns and operates a community-based rural health care delivery system (the Mayo Clinic Health System; MCHS) which extends through 49 rural communities in southern Minnesota, western Wisconsin, and northeastern Iowa. 

For the past eight years, Mayo Clinic has been ranked as the No. 1 health system in the nation and the world, with the most #1 ranked medical specialties, by U.S. News & World Report, Newsweek, and other healthcare quality organizations. Each of the Mayo Clinic hospitals on the three Mayo Clinic campuses have also been consistently ranked as the #1 hospital and the #1 cancer center and cancer hospital in their respective state.  Mayo Clinic also has the largest integrated organ transplant program in the nation and conducts more clinical trials driving research and testing new therapies and interventions compared to any other institution in the United States. In 2025, with a staff of more than 85,000, including more than 7,300 physicians and scientific investigators, Mayo Clinic cared for more than 1.3 million unique patients who came from all 50 U.S. states and 135 countries.             

Mayo Clinic: The 2030 Bold. Forward. Strategic Plan
Health care has operated in an environment where patients have had the least control. Technology, data-driven knowledge, artificial intelligence (AI), consumerism, and "platform thinking" will establish the next generation of health care. To thrive in this environment, healthcare organizations must break through the old paradigm and transform scientific research and healthcare access and delivery on behalf of the patients we serve. By remaining true to its primary value, 'the needs of the patient come first,' and the RICH TIES core values of Respect, Integrity, Compassion, Healing, Teamwork, Innovation, Excellence, Stewardship, Mayo Clinic is driving the transformation of biomedical research and health care through its 2030 Bold. Forward. Strategic Plan with the framework Cure, Connect, and Transform.

Cure.
Cure is dedicated to accelerating discovery, translation, and delivery of more cures for both chronic and acute diseases. Mayo Clinic is differentiating itself through the conduct of highly innovative discovery science and its translation to enable the delivery and diffusion of the next generation of diagnoses, treatments, and cures. This includes new in vivo and in vitro medical, surgical, and radiologic therapies and interventions delivered physically within our healthcare facilities and digitally and virtually in patient's homes and community settings. 

Connect.
Connect is focused on connecting people with data to create new knowledge and delivering scalable, end-to-end solutions. This means making our healthcare delivery systems more accessible for patients, but also easier for providers, researchers, and other partners to collaborate to conduct research and clinical practice to create new solutions.  In new programs such as Mayo Clinic Care Beyond Walls, Cancer Care Beyond Walls (CCBW), and Clinical Trials Beyond Walls (CTBW), Mayo Clinic is creating a digital care delivery model that maintains a human touch. 

Transform.
Transform means creating a new future for healthcare focused on a scalable, AI-enabled platform for the conduct of research and care delivery. Mayo Clinic is driving the "platform transformation" of health care by creating Mayo Clinic Platform - what we believe is the first true large-scale platform in health care - and building highly innovative research and clinical programs, including the Mayo Clinic Generative Artificial Intelligence (GenAI) Program.

Mayo Clinic Platform
To drive the "platform transformation" of healthcare, Mayo Clinic has created the Mayo Clinic Platform (MCP), healthcare's first comprehensive, dynamic, scalable, AI-enabled research engine and patient care platform. Through MCP, Mayo Clinic has created the world's largest collaborative, distributed, federated healthcare data network (MCP Connect), with a cloud-based data architecture holding the longitudinal healthcare records of 54 million patients from across the world.  Four MCP Connect network members are ranked among the world's top 10 healthcare systems (Mayo Clinic, University Health Network (UHN) - University of Toronto/Princess Margaret Cancer Centre, Sheba Health System of Israel, and Singapore National Health (SingHealth)). From Mayo Clinic alone, MCP holds the fully digitized longitudinal healthcare records from 15M Mayo Clinic patients, including 705 million patient encounters, 3.2 billion laboratory results, 1.65 billion clinical notes, 8.1 billion radiographic images (X-ray, CT, MRI, PET), the world's largest repository of digitized pathology slides (20 million), and 662 million diagnoses. The clinical data in MCP is further linked to repositories of patient biospecimens and highly annotated epidemiologic and research data sets, facilitating scientific discovery and t...