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Alnylam Pharmaceuticals

Scientist, mRNA

Cambridge, MA · On-site

$110.40K - $165.60K/yr

Design mRNA compositions to drive high, persistent in vivo expression of target proteins resulting in robust immune responses in animal models * Systematically optimize mRNA designs to enhance ...

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How much do mrna jobs pay per year?

As of May 30, 2026, the average yearly pay for mrna in the United States is $100,231.00, according to ZipRecruiter salary data. Most workers in this role earn between $68,500.00 and $132,000.00 per year, depending on experience, location, and employer.

What is an mRNA job?

An mRNA job typically involves research, development, or manufacturing related to messenger RNA (mRNA) technology. Professionals in this field work in biotechnology, pharmaceuticals, or academia, focusing on mRNA-based therapies, including vaccines and treatments for various diseases. Roles can include scientists, researchers, lab technicians, and manufacturing specialists. These positions require expertise in molecular biology, genetics, and bioinformatics. The field has grown significantly due to the success of mRNA vaccines in combating infectious diseases.

What are the key skills and qualifications needed to thrive as an mRNA Scientist, and why are they important?

To thrive as an mRNA Scientist, you need a strong background in molecular biology, biochemistry, and genetics, typically supported by an advanced degree in a life science field. Familiarity with laboratory techniques such as PCR, RNA sequencing, and experience with bioinformatics tools are essential, along with knowledge of regulatory and quality standards. Excellent analytical thinking, problem-solving skills, and effective communication are important soft skills for collaborating on research teams and conveying complex findings. These qualifications are crucial for driving innovation, ensuring experimental accuracy, and advancing mRNA-based therapeutics or vaccines.

What are some common challenges faced by mRNA scientists when scaling up production from laboratory to commercial levels?

One of the main challenges mRNA scientists encounter during scale-up is ensuring product consistency and purity while transitioning from small-batch laboratory synthesis to large-scale manufacturing. This often requires adapting protocols and validating processes to meet strict regulatory standards. Additionally, optimizing delivery systems and maintaining stability of mRNA molecules can be complex. Collaboration with cross-functional teams, such as quality control, process engineering, and regulatory affairs, is essential to address these challenges and ensure successful commercialization.

What are mRNA jobs?

mRNA jobs refer to positions that focus on the research, development, manufacturing, and application of messenger RNA (mRNA) technologies. These roles can be found in biotechnology and pharmaceutical companies, academic institutions, and research laboratories. Job titles may include mRNA scientist, research associate, process development engineer, and quality control analyst. Professionals in these roles typically work on developing mRNA-based vaccines, therapeutics, and drug delivery systems.

What is the job of mRNA?

A job related to mRNA involves working with messenger RNA molecules, which carry genetic information from DNA to the cell's protein-making machinery. Roles may include research, development of vaccines, or laboratory analysis in biotechnology or healthcare settings, often requiring knowledge of molecular biology and laboratory techniques.

What is the difference between Mrna vs Rna Polymerase?

AspectMrnaRna Polymerase
Primary FunctionMessenger RNA that carries genetic information from DNA to ribosomes for protein synthesisEnzyme responsible for synthesizing RNA from a DNA template during transcription
Work EnvironmentFound in the cytoplasm and nucleus of cellsLocated in the nucleus, functioning during transcription
Required CredentialsTypically no formal credentials; knowledge of molecular biologyBiochemists or molecular biologists with specialized training

Mrna and Rna Polymerase are closely related in gene expression. Mrna is the RNA molecule that conveys genetic information, while Rna Polymerase is the enzyme that synthesizes Mrna during transcription. Understanding their roles helps clarify how genetic information is converted into proteins in cells.

More about Mrna jobs
What cities are hiring for Mrna jobs? Cities with the most Mrna job openings:
What are the most commonly searched types of Mrna jobs? The most popular types of Mrna jobs are:
What states have the most Mrna jobs? States with the most job openings for Mrna jobs include:
What job categories do people searching Mrna jobs look for? The top searched job categories for Mrna jobs are:
Mrna jobs near you
Infographic showing various Mrna job openings in the United States as of May 2026, with employment types broken down into 86% Full Time, and 14% Part Time. Highlights an 100% In-person job distribution, with an average salary of $100,231 per year, or $48.2 per hour.
Scientist, mRNA

Scientist, mRNA

Alnylam Pharmaceuticals

Cambridge, MA • On-site

$110.40K - $165.60K/yr

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Posted 4 days ago

Job description

Overview
The Delivery Sciences team at Alnylam is seeking a Scientist to contribute to our ligand discovery efforts for expanding RNAi delivery to all tissues. The successful candidate will help drive ligand discovery and selection efforts through design and characterization of mRNA formulations. This role requires a strong background in molecular biology and biochemistry, along with hands-on expertise in designing and optimizing stabilized mRNA for in vivo applications. The individual will need excellent organization and communication skills to work collaboratively across multiple groups in the research organization.
This position is onsite and will be primarily located in Cambridge, MA.
Key Responsibilities
  • Design mRNA compositions to drive high, persistent in vivo expression of target proteins resulting in robust immune responses in animal models
  • Systematically optimize mRNA designs to enhance translation efficiency, structural stability, and extended in-cell lifetime.
  • Implement optimized mRNA designs for binder discovery in collaboration with teams across research
  • Prepare clear and well-structured experimental reports and data presentations
  • Contribute to a cross-functional team of biologists, chemists, and pharmacologists to drive the strategic direction of research programs across multiple therapeutic modalities

Qualifications
  • PhD in Molecular Biology and biochemistry with 1-3 years relevant industry/academic experience
  • Expertise in mRNA design, optimization, preparation and characterization
  • Demonstrated proficiency in mRNA antigen design and immunization strategies for binder discovery
  • Hands-on experience in self-amplifying RNA is preferred
  • Experience in NGS library preparation and bioinformatic analysis of high throughput sequencing data will be a plus
  • Strong experimental design/execution, rigorous data analysis, diligent record keeping (ELN, inventory management), and the ability to manage multiple projects in parallel are required

Excellent communication skills (both written and oral) are essential.
#LI-JR1
U.S. Pay Range
$110,400.00 - $165,600.00
The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).
Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.
Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers
About Alnylam
We are the leader in RNAi therapeutics - a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.
At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

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