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Lead Systems Engineer Jobs in Missouri (NOW HIRING)

Boeing

Lead Systems Integrator

Berkeley, MO · On-site

In this role, you will lead the development, analysis, and integration of innovative engineering solutions for critical Ground System capabilities and ensure seamless support for ground systems from ...

Boeing

Lead Systems Integrator

Berkeley, MO · On-site

In this role, you will lead the development, analysis, and integration of innovative engineering solutions for critical Ground System capabilities and ensure seamless support for ground systems from ...

Judge Group, Inc.

Systems Engineer 3

Saint Louis, MO · On-site

Demonstrated experience developing system architectures for complex aerospace vehicles or subsystems using MBSE (SysML/MSOSA) Prior leadership in system architecture or lead systems engineering roles ...

Jobtailor

Principal Systems Engineer

California, MO · On-site

$180 - $240/hr

Lead the architecture, integration, and validation of complex systems for advanced semiconductor ... Collaborate with optical, mechanical, electrical, and software engineering teams * Support project ...

New

Biomerieux

Lead System Engineer

Hazelwood, MO · On-site

$150K - $205K/yr

Systems Engineering or Biomedical Engineering Preferred * Demonstrated experience in the design of ... complex medical (or equivalent) device systems with focus on minimizing timelines and maximizing ...

bioMérieux

Lead System Engineer

Hazelwood, MO · On-site

$150K - $205K/yr

Systems Engineering or Biomedical Engineering Preferred * Demonstrated experience in the design of complex medical (or equivalent) device systems with focus on minimizing timelines and maximizing ...

BioFire Diagnostics

Lead System Engineer

Hazelwood, MO · On-site

$150K - $205K/yr

Systems Engineering or Biomedical Engineering Preferred * Demonstrated experience in the design of ... complex medical (or equivalent) device systems with focus on minimizing timelines and maximizing ...

bioMerieux

Lead System Engineer

Hazelwood, MO · On-site

$150K - $205K/yr

Systems Engineering or Biomedical Engineering Preferred * Demonstrated experience in the design of ... complex medical (or equivalent) device systems with focus on minimizing timelines and maximizing ...

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All JobsLead Systems Engineer JobsLead Systems Engineer Jobs in Missouri

Lead Systems Engineer information

See Missouri salary details

$85.4K

$187K

$237.3K

How much do lead systems engineer jobs pay per year?

As of Aug 7, 2026, the average yearly pay for lead systems engineer in Missouri is $186,970.00, according to ZipRecruiter salary data. Most workers in this role earn between $156,600.00 and $237,300.00 per year, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a lead systems engineer?

To thrive as a Lead Systems Engineer, you need advanced knowledge in systems architecture, network administration, and troubleshooting, usually backed by a degree in computer science or engineering. Familiarity with tools like VMware, Linux/Windows operating systems, cloud platforms (AWS, Azure), and certifications such as CISSP or CompTIA are often required. Strong leadership, project management, and communication skills enable effective team coordination and successful project delivery. These skills are vital for designing robust systems, ensuring reliability, and driving innovation within technical teams.

How does a lead systems engineer typically collaborate with cross-functional teams during large-scale projects?

A Lead Systems Engineer plays a central role in coordinating with cross-functional teams such as software developers, network specialists, project managers, and QA engineers. They facilitate clear communication between technical and non-technical stakeholders, ensuring requirements are well-understood and that implementation stays on track. Lead Systems Engineers often organize and lead design reviews, troubleshoot integration challenges, and mediate technical decisions to align with overall business goals. This collaborative approach is essential for delivering complex system solutions efficiently and effectively.

What is the difference between Lead Systems Engineer vs Systems Engineer?

AspectLead Systems EngineerSystems Engineer
CredentialsBachelor's or higher in Engineering, certifications like INCOSE, PMP often preferredBachelor's degree in Engineering or related field, certifications optional
Work EnvironmentLeading projects, coordinating teams, overseeing system design and integrationSupporting system development, testing, and implementation tasks
Employer & IndustryTechnology, aerospace, defense, manufacturing companiesSimilar industries, often within larger engineering teams
Search & Comparison IntentUnderstanding leadership roles, project management, advanced responsibilitiesEntry to mid-level system design and support roles

The main difference between a Lead Systems Engineer and a Systems Engineer lies in their responsibilities and leadership scope. Lead Systems Engineers oversee project coordination, team management, and system integration, often requiring additional certifications and experience. Systems Engineers focus on supporting system development and testing. Both roles are vital in engineering projects, but the Lead role emphasizes leadership and strategic oversight.

What does a lead systems engineer do?

A Lead Systems Engineer oversees the design, integration, and management of complex systems within an organization. They coordinate teams, ensure system reliability and security, and often serve as the primary technical point of contact for projects. Their responsibilities include evaluating system requirements, troubleshooting issues, and ensuring that all components work harmoniously. Lead Systems Engineers also mentor junior staff and collaborate with other departments to ensure project success.
What are the most commonly searched types of Lead Systems Engineer jobs in Missouri? The most popular types of Lead Systems Engineer jobs in Missouri are:
What are popular job titles related to Lead Systems Engineer jobs in Missouri? For Lead Systems Engineer jobs in Missouri, the most frequently searched job titles are:
What job categories do people searching Lead Systems Engineer jobs in Missouri look for? The top searched job categories for Lead Systems Engineer jobs in Missouri are:
What cities in Missouri are hiring for Lead Systems Engineer jobs? Cities in Missouri with the most Lead Systems Engineer job openings:
What are popular job titles related to Lead Systems Engineer jobs in MO? For Lead Systems Engineer jobs in MO, the most frequently searched job titles are:
Lead Systems Engineer jobs near you
Infographic showing various Lead Systems Engineer job openings in Missouri as of August 2026, with employment types broken down into 85% Full Time, 9% Part Time, and 6% Contract. Highlights an 89% Physical, 3% Hybrid, and 8% Remote job distribution, with an average salary of $186,970 per year, or $89.9 per hour.

Onsite Job - Aerospace Systems Engineer 4

Indotronix International Corporation

Hazelwood, MO • On-site

$85 - $88/hr

Contractor

Re-posted 7 days ago

Job description

Indotronix is seeking an Aerospace Systems Engineer 4, Hazelwood, MO
 
Bachelor Must
Shift: First
Start Time: 8:00 AM
End Time: 5:00 PM
Requested Security Clearance: Active Secret
 
Position Responsibilities:
Support/lead system architecture development and decomposition using MBSE (SysML/Cameo) to define interfaces, functions, and allocation across multiple domains
Support/lead cross-functional engineering teams in developing systems to meet program commitments, including support of design reviews
Support/lead the program in implementing MBSE as part of broad digital engineering ecosystem
Support/lead Systems Engineering efforts such as requirements decomposition, system architecture, system analysis, specification development, trade studies, program planning, interfaces management, risk management, certification planning & execution, verification & test planning, and overall integration and capture them in the MBSE model as appropriate
This position is expected to be 100% on-site. The selected candidate will be required to work on-site at one of the listed location options.
Basic Qualifications (Required Skills/Experience):
Bachelor of Science degree from an accredited course of study in engineering, engineering technology (including manufacturing engineering technology), chemistry, physics, mathematics, data science, or computer science
7+ years of work-related engineering experience with a Bachelor's or 3+ years of work-related engineering experience with a relevant Master's or PhD
Prior Systems Engineering experience to include but not limited to system design, functional decomposition, requirements development, analysis, verification, and validation
Experience with MBSE, Cameo/MSOSA, and/or SysML
Active Secret Clearance
Preferred Qualifications (Required Skills/Experience):
Demonstrated experience developing system architectures for complex aerospace vehicles or subsystems using MBSE (SysML/MSOSA)
Prior leadership in system architecture or lead systems engineering roles; experience communicating architectural tradeoffs to stakeholders and customers
Understanding of various engineering analyses, including affordability, safety, reliability, maintainability, testability, human systems integration, survivability, vulnerability, susceptibility, system security, regulatory, certification, product assurance and other specialties quality factors into a preferred configuration to ensure mission success
Familiarity with aircraft/flight systems and domain-specific engineering (ME, EE, SW) to evaluate integration impacts.
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About Indotronix

Sourced by ZipRecruiter

In 1986, Indotronix established itself in the staffing space. 22 years later, Avani entered the scene, offering consulting and technology development. Finally, in 2016, the two joined forces to begin delivering talent across all areas, from Staffing to Consulting to unique platform development.

Industry

Recruiting and staffing services

Company size

1,001 - 5,000 Employees

Headquarters location

Rochester, NY, US

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