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Lead Statistical Programmer Jobs (NOW HIRING)

BeiGene, Ltd.

$150 - $200/hr

The role serves as a technical lead and project manager, partners cross-functionally, and supports ... related to statistical and clinical programming, as needed. • Represent the Statistical ...

BeiGene USA

(Senior) Principal Statistical Programmer

$144K - $189K/yr

Technically lead and project manage multiple studies, managing all aspects of study deliverables related to statistical and clinical programming, as needed. Represent the Statistical Programming team ...

OneWe Reach

Principal Statistical Programmer

Durham, NC · On-site

$150 - $200/hr

Lead programming for studies, ensuring efficient development and validation of analysis packages. * Select appropriate tools/languages and solve complex technical challenges. * Identify and implement ...

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How much do lead statistical programmer jobs pay per hour?

As of Sep 9, 2026, the average hourly pay for lead statistical programmer in the United States is $54.96, according to ZipRecruiter salary data. Most workers in this role earn between $43.27 and $68.75 per hour, depending on experience, location, and employer.

What does a lead statistical programmer do?

A Lead Statistical Programmer oversees and manages the programming aspects of clinical trial data analysis. They are responsible for developing, validating, and maintaining statistical programs used to analyze clinical data, typically using software like SAS. In addition to technical programming, they coordinate with statisticians, data managers, and project teams to ensure data integrity and compliance with regulatory standards. Lead Statistical Programmers often mentor junior programmers and play a key role in project planning and timeline management.

What are the key skills and qualifications needed to thrive as a lead statistical programmer, and why are they important?

To thrive as a Lead Statistical Programmer, you need expertise in statistical programming languages like SAS or R, a solid understanding of clinical trial data, and a relevant degree in statistics, mathematics, or a related field. Familiarity with CDISC standards (SDTM, ADaM), regulatory submission processes, and version control systems are essential technical requirements. Strong leadership, communication, and problem-solving skills help in managing teams and collaborating across departments. These skills ensure accurate, compliant data analysis and efficient project delivery in a highly regulated environment.

What are some common challenges faced by a lead statistical programmer, and how can they be managed?

Lead Statistical Programmers often encounter challenges such as balancing multiple project timelines, ensuring compliance with regulatory standards, and coordinating effectively with cross-functional teams like biostatistics and clinical operations. Managing these challenges requires strong organizational and communication skills, as well as a proactive approach to problem-solving and stakeholder engagement. Regularly updating programming knowledge and fostering collaboration within the team can also help streamline workflows and maintain high-quality deliverables.

What is the difference between Lead Statistical Programmer vs Statistical Programmer?

AspectLead Statistical ProgrammerStatistical Programmer
CredentialsTypically requires a Bachelor's or Master’s in Biostatistics, Statistics, or related field; experience in clinical trialsSame educational background; entry to mid-level experience
Work EnvironmentLeads project teams, manages timelines, and oversees statistical analysisPerforms statistical programming tasks under supervision
Industry UsageUsed across pharmaceutical, biotech, and CROs for leadership rolesCommonly employed in similar settings for technical execution

The main difference between a Lead Statistical Programmer and a Statistical Programmer lies in leadership responsibilities, project management, and oversight. The Lead typically manages teams and ensures project delivery, while the Statistical Programmer focuses on executing statistical analyses under guidance.

How much does a lead statistical programmer make in the US?

A lead statistical programmer in the US typically earns between $100,000 and $130,000 annually, depending on experience, location, and the size of the organization. Senior roles often include additional benefits such as bonuses and health insurance, and proficiency in programming languages like SAS or R is usually required.
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Lead Statistical Programmer jobs near you
Infographic showing various Lead Statistical Programmer job openings in the United States as of September 2026, with employment types broken down into 88% Full Time, 10% Part Time, and 2% Contract. Highlights an 88% Physical, 3% Hybrid, and 9% Remote job distribution, with an average salary of $114,323 per year, or $55 per hour.

Principal Programmer, Statistical Programming (Remote)

Boston, MA • On-site, Remote

Vertex Pharmaceuticals
Biotechnology Research and Development • 1 - 5K employees
Learn more about Vertex Pharmaceuticalsexternal

$149K - $223K/yr

Full-time

Medical, Dental, Vision, Retirement, PTO

Posted 15 days ago

Vertex Pharmaceuticals rating

6.5

Company rating: 6.5 out of 10

Based on 5 frontline employees who took The Breakroom Quiz

78th of 86 rated pharmaceutical

Job description

Job Description
General Summary:
The Principal Statistical Programmer works with management to delegate tasks appropriately, track progress, and provide expert technical support to team members. In addition, the Principal Statistical Programmer is a designated member of clinical sub-team(s) in the role of project lead Statistical Programmer.
Key Duties and Responsibilities:
  • Works regularly with advanced features of SAS (including interfacing ability with other software applications and operating system tools)
  • Performs quality control checks of SAS code and output produced by other Statistical Programmers to ensure accuracy and consistency within group
  • Demonstrates in-depth knowledge of clinical development and medical data
  • Solves complex clinical trial reporting problems and demonstrates technical proficiency and exercises judgment in supporting daily operations and ensuring that study tasks are completed accurately and in a timely manner
  • Engages with a variety of other functions, including Statistical Programmers, Biostatisticians, Data Management, and other departments engaged in providing data and submission-related activities, often at Senior Management levels
  • Creates all files, documents, and analyses necessary to support an electronic submission in eCTD format, including ISS/ISE
  • Provides leadership to ensure compliance with Vertex SOP'S and FDA/ICH/GCP regulations
  • Provides technical and project management skills to create, review, and approve documentation required to support data analysis, reporting, and CDlSC data submission
  • Participates in project management cross-functional teams that work on standard operating procedures, guidelines, process improvements, system validation and acquisition, customization, and integration of new tools and technologies

Knowledge and Skills:
  • Proficiency in all SAS language, procedures, and functions commonly used in clinical trial reporting including the Macro language, BASE SAS, SAS/STAT and SAS/GRAPH
  • Intermediate knowledge of CDISC Standards
  • Intermediate knowledge of clinical trials
  • Regulatory submission experiences
  • Effective communication (written and verbal) skills to explain difficult information

Education and Experience:
  • Bachelors degree in a Scientific Discipline
  • Typically requires 5+ for M.S. or above and 8+ years for B.S. years of work experience in Biotech, Pharmaceuticals or Clinical Research Organization

Pay Range 136,960.00 - 205,440.00 USD annually
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.
At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.
#LI-AR1
#LI-Remote
Pay Range:
$149,200 - $223,800
Disclosure Statement:
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.
At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.
Flex Designation:
Remote-Eligible
Flex Eligibility Status:
In this Remote-Eligible role, you can choose to be designated as:
1. Remote: work remotely five days per week and come into the office on occasion - you're always welcome on-site; or select
2. Hybrid: work remotely up to two days per week; or select
3. On-Site: work five days per week on-site with ad hoc flexibility.
Note: The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.
#LI-Remote
Company Information
Vertex is a global biotechnology company that invests in scientific innovation.
Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.
Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at ApplicationAssistance@vrtx.com

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