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Informatics Engineer Jobs in Boston, MA (NOW HIRING)

Prime Medicine

Informatics Engineer

Cambridge, MA · On-site

About the role We're hiring an Informatics Engineer to build the scientific data and computing platform that powers Prime Medicine's gene editing programs. You will work in close partnership with our ...

Prime Medicine

Informatics Engineer

Cambridge, MA

About the role We're hiring an Informatics Engineer to build the scientific data and computing platform that powers Prime Medicine's gene editing programs. You will work in close partnership with our ...

Watershed Informatics

Software Engineer, UI

Boston, MA

$113K - $151K/yr

... Watershed Informatics is hiring an experienced UI Software Engineer to design and build powerful interface features for our genomic analysis and system management software. We're looking for ...

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All JobsInformatics Engineer JobsInformatics Engineer Jobs in Boston, MA

Informatics Engineer information

See Boston, MA salary details

$42.4K

$110.5K

$149.4K

How much do informatics engineer jobs pay per year?

As of Jul 13, 2026, the average yearly pay for informatics engineer in Boston, MA is $110,544.00, according to ZipRecruiter salary data. Most workers in this role earn between $91,300.00 and $126,600.00 per year, depending on experience, location, and employer.

What engineers make $300,000 a year?

Senior-level engineers in specialized fields such as software engineering, data engineering, and systems architecture can earn $300,000 or more annually, especially with extensive experience, advanced skills, and working in high-demand industries like technology or finance. Roles often require advanced certifications, leadership responsibilities, and expertise in tools like cloud platforms or programming languages.

How does an Informatics Engineer typically collaborate with cross-functional teams in a healthcare setting?

Informatics Engineers often work closely with clinicians, IT professionals, and administrative staff to ensure that health information systems meet the needs of all stakeholders. They facilitate communication between technical and non-technical team members, translate clinical requirements into technical specifications, and support the integration of new technologies. This collaborative approach helps ensure that data workflows are efficient, secure, and aligned with healthcare regulations. Regular meetings, user training sessions, and feedback loops are common aspects of this teamwork.

What are Informatics Engineers?

Informatics Engineers are professionals who design, develop, and maintain systems that manage and process information, often in fields like healthcare, business, or research. They combine expertise in computer science, information technology, and domain-specific knowledge to develop solutions that improve data management, analysis, and security. Their work often involves creating software tools, managing databases, and ensuring the efficient flow of information within organizations. Informatics Engineers play a crucial role in integrating technology with real-world processes to enhance decision-making and operational efficiency.

Which is the hardest field in it?

Informatics engineering involves complex fields such as cybersecurity, data science, and software development, each with its own challenges. Cybersecurity is often considered one of the most difficult due to constantly evolving threats and the need for specialized knowledge of networks, cryptography, and threat mitigation. Success in this field requires continuous learning and proficiency with tools like intrusion detection systems and programming languages.

What is the difference between Informatics Engineer vs Data Analyst?

AspectInformatics EngineerData Analyst
Required CredentialsBachelor's or higher in Computer Science, Information Systems, or related fieldsBachelor's in Statistics, Mathematics, or related fields; often with data analysis certifications
Work EnvironmentHealthcare, technology, or research settings focusing on information systemsBusiness, finance, marketing, or healthcare sectors analyzing data trends
Employer & Industry UsageDevelops and manages health or information systems in healthcare and tech industriesInterprets data to inform business decisions across various industries

Informatics Engineers and Data Analysts both work with data, but Informatics Engineers focus on developing and managing information systems, especially in healthcare and tech sectors. Data Analysts primarily interpret data to support business insights. While their skills overlap, their roles differ in scope and application.

What are the key skills and qualifications needed to thrive as an Informatics Engineer, and why are they important?

To thrive as an Informatics Engineer, you need a strong background in computer science, data management, and information systems, usually supported by a relevant degree and experience in software development. Familiarity with programming languages (such as Python or Java), database systems (like SQL), and health informatics standards or certifications (e.g., HL7, Certified Health Informatician) is commonly required. Strong analytical thinking, problem-solving, and effective communication skills help bridge the gap between technical teams and stakeholders. These skills ensure the efficient design, implementation, and maintenance of information systems that support organizational goals and data-driven decision-making.

What is an informatics engineer?

An informatics engineer designs, develops, and manages information systems that integrate computer science and healthcare or other domains. They often work with data analysis, software development, and system implementation, requiring skills in programming, databases, and domain-specific knowledge.

What engineers make $500,000?

Highly experienced engineers in specialized fields such as software engineering, data engineering, or systems engineering can earn $500,000 or more annually, especially in senior or executive roles. These positions often require advanced skills, certifications, and extensive industry experience, typically in high-demand sectors like technology or finance.
What are popular job titles related to Informatics Engineer jobs in Boston, MA? For Informatics Engineer jobs in Boston, MA, the most frequently searched job titles are:
What job categories do people searching Informatics Engineer jobs in Boston, MA look for? The top searched job categories for Informatics Engineer jobs in Boston, MA are:
Informatics Engineer jobs near you
Informatics Engineer

Informatics Engineer

Prime Medicine

Cambridge, MA • On-site

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Re-posted 24 days ago

Job description

Company Overview:
Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.
Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology & oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.
About the role
We're hiring an Informatics Engineer to build the scientific data and computing platform that powers Prime Medicine's gene editing programs.
You will work in close partnership with our computational biology team and our cloud infrastructure team. The role suits someone who's comfortable owning a platform end-to-end, building the engineering foundations that scientists across the organization rely on, including data pipelines and APIs through to AI-enabled internal tooling. Your engineering judgment about what to build and how to build it will shape how Prime Medicine works with scientific data day-to-day.
What you'll do
  • Design and build the data platform connecting NGS instruments, laboratory informatics systems (Benchling), and AWS cloud compute; covering automated ingestion, provenance tracking, scalable storage, and observability.
  • Build production-grade APIs, SDKs, and internal tools that bring genomic data and analytical capabilities to scientists across the organization.
  • Build the orchestration layer for the automated, event-triggered execution of our scientific pipelines. The pipelines themselves (amplicon-seq, off-target analysis, and others) are co-developed with our computational biology team; you'll own how they run, scale, and integrate.
  • Ship AI-powered and agentic capabilities such as RAG over internal scientific data, agentic workflows with human-in-the-loop review, and internal copilots that streamline routine workflows across the organization connecting both science and business needs.
  • Build integrations across the scientific tool chain so data moves reliably between ELNs, LIMS, instrument software, and cloud compute.
  • Translate scientific requirements into reliable, maintainable software, helping bring research prototypes into production-grade systems.
  • Partner with computational biologists, lab scientists, and our cloud-support team to continuously improve platform performance, cost, and reliability.

What we're looking for
This is an Infrastructure engineering focused role, well suited to candidates whose primary background is software engineering, data engineering, or scientific platform engineering, with a strong interest in applying those skills to scientific problems.
Requirements:
  • 5+ years of full-time engineering experience (3+ for those with an MS or PhD) in production environments.
  • Strong Python programming skills.
  • Production AWS experience with depth in event-driven, cloud-native architectures, including AWS Lambda, EventBridge (or comparable event-routing infrastructure), and Infrastructure as Code with Terraform or CDK.
  • Docker / containerization, Git-based workflows, CI/CD, code review, and testing code in DEV/TEST environments before deploying to production.
  • A track record of building integrations and automations. Experience in a life-science related industry involving scientific or regulated data, such as biotech, pharma, healthtech, clinical informatics, scientific instrumentation, or agricultural genomics.

Nice to have
  • NGS expertise. Knowledge of NGS technology, workflows and pipeline architecture is strongly preferred.
  • Hands-on workflow orchestration experience. Familiarity with Nextflow/NextFlow Tower/Seqera Platform preferred.
  • Laboratory informatics experience with Benchling or comparable ELN/LIMS, as an operator, builder, or administrator.
  • AI / LLM tooling and agentic systems (LangChain, LangGraph, MCPs, RAG architectures).
  • Gene editing familiarity: CRISPR, base editing, prime editing.
  • GxP / 21 CFR Part 11 / regulated-software experience.
  • Plotly Dash, Streamlit, Spotfire, Retool, or similar tools for internal apps and data visualizations.
  • Experience managing or querying relational databases (PostgreSQL, MSSQL).

Interview process
The process includes a recruiter conversation, a hiring manager interview, and a small panel that includes computational biology, engineering, and wet lab partners. A Python coding exercise is part of the process
Logistics and policy
  • Hybrid with office in Cambridge, MA. We are not currently able to sponsor visas. US work authorization at the time of application is required.
  • Competitive base salary, equity, and standard benefits.

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on several factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus) and an annual long-term incentive award (e.g., equity).
Prime Medicine offers a comprehensive Total Rewards package with robust health, financial, and wellness benefits-including medical, dental, vision, life insurance, a 401(k) match, and equity programs-along with generous paid time off, wellness days, and company-wide recharge breaks.
Our commitment to employee well-being reflects our belief that when we care for our people, we strengthen our ability to put patients first and make meaningful impact together.
U.S. Pay Range
$134,000-$163,000 USD
Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

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