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High Performance Liquid Chromatography Jobs (NOW HIRING)

Chemist I

Rockville, MD · On-site

$59K - $87K/yr

KNOWLEDGE, SKILLS AND ABILITIES: • Familiarity with organic chemistry techniques such as chromatography, rotary evaporation, phase separations, High Performance Liquid Chromatography (HPLC ...

Metrologist

Clinton, MI · On-site

$90K - $140K/yr

Equipment Serviced: • Gas Chromatography Mass Spectrometers • High Performance Liquid Chromatographs • Gas Chromatographs • Liquid Chromatography Mass Spectrometers • Ion Spectrometers • ...

New

Perform analytical and identification determinations using various lab instrumentation such as High Performance Liquid Chromatography, Gas Chromatography (thermal and flame), Infrared ...

Utilize various analytical instrumentation including but not limited to Gas Chromatography (GC), high-performance liquid chromatography (HPLC/UHPLC), ICP-MS, Infrared spectroscopy (IR), Differential ...

Utilize various analytical instrumentation including but not limited to Gas Chromatography (GC), high-performance liquid chromatography (HPLC/UHPLC), ICP-MS, Infrared spectroscopy (IR), Differential ...

Utilize various analytical instrumentation including but not limited to Gas Chromatography (GC), high-performance liquid chromatography (HPLC/UHPLC), ICP-MS, Infrared spectroscopy (IR), Differential ...

Instrument Technician

Springfield, OH · On-site

$90K - $140K/yr

... High Performance Liquid Chromatography, Gas Chromatography, Liquid Chromatography-Mass Spectrometry, Mass Spectrometry, or similar. Requirements: • Willingness and ability to travel to customer ...

Instrument Technician

Surry, NH · On-site

$90K - $140K/yr

... High Performance Liquid Chromatography, Gas Chromatography, Liquid Chromatography-Mass Spectrometry, Mass Spectrometry, or similar. Requirements: • Willingness and ability to travel to customer ...

Instrument Technician

Johnston, RI · On-site

$90K - $140K/yr

... High Performance Liquid Chromatography, Gas Chromatography, Liquid Chromatography-Mass Spectrometry, Mass Spectrometry, or similar. Requirements: • Willingness and ability to travel to customer ...

Lab Instrument Technician

Revere, MA · On-site

$90K - $140K/yr

Instruments: • High Performance Liquid Chromatographs • Ultra Performance Liquid Chromatographs • Gas Chromatographs • Liquid Chromatography Mass Spectrometers • Gas Chromatography Mass ...

New

Lab Maintenance Technician

Riverton, WY · On-site

$90K - $140K/yr

Seeking experience installing, troubleshooting, tuning, and repairing precision analytical instruments performing High Performance Liquid Chromatography, Gas Chromatography, Spectrometry, Elemental ...

Lab Maintenance Technician

Yonkers, NY · On-site

$90K - $140K/yr

Seeking experience installing, troubleshooting, tuning, and repairing precision analytical instruments performing High Performance Liquid Chromatography, Gas Chromatography, Spectrometry, Elemental ...

New

Instrumentation Technician

Martinez, GA · On-site

$90K - $140K/yr

Seeking experience installing, troubleshooting, tuning, and repairing precision analytical instruments performing High Performance Liquid Chromatography, Gas Chromatography, Spectrometry, Elemental ...

New

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High Performance Liquid Chromatography information

See salary details

$40K

$99.5K

$153.5K

How much do high performance liquid chromatography jobs pay per year?

As of Jul 14, 2026, the average yearly pay for high performance liquid chromatography in the United States is $99,528.00, according to ZipRecruiter salary data. Most workers in this role earn between $65,500.00 and $126,000.00 per year, depending on experience, location, and employer.

What does high performance liquid chromatography do?

High Performance Liquid Chromatography (HPLC) is a technique used by analytical chemists to separate, identify, and quantify components in complex mixtures. It involves passing a liquid sample through a column packed with a stationary phase, allowing for precise analysis of substances such as pharmaceuticals, environmental samples, and biological materials. HPLC skills are essential for roles involving quality control, research, and method development in laboratories.

Which company HPLC is best?

High Performance Liquid Chromatography (HPLC) is a technique used across many industries, and several companies manufacture reliable HPLC systems, including Agilent Technologies, Waters Corporation, Shimadzu, and Thermo Fisher Scientific. The best choice depends on specific laboratory needs, budget, and required features such as sensitivity, throughput, and software compatibility. Job seekers in this field should focus on gaining skills in operating and maintaining these systems, as well as understanding their applications in analytical chemistry.

What is another name for high performance liquid chromatography?

High Performance Liquid Chromatography (HPLC) is also known as high-pressure liquid chromatography. It is a technique used in analytical chemistry to separate, identify, and quantify components in a mixture, often performed using specialized equipment and trained personnel.

What careers use chromatography?

Careers that use chromatography include roles in analytical chemistry, pharmaceutical research, environmental testing, food safety, and clinical laboratory analysis. Professionals in these fields operate chromatography instruments to separate, identify, and quantify chemical compounds, often requiring knowledge of laboratory techniques and instrumentation. Skills in data analysis and certification in laboratory practices are also valuable in these careers.

What are some typical daily responsibilities for someone working with High Performance Liquid Chromatography (HPLC)?

In an HPLC role, your daily responsibilities often include preparing samples, calibrating and maintaining HPLC instruments, running analytical tests, and interpreting chromatographic data. You may also be responsible for troubleshooting equipment issues, documenting results in lab notebooks or electronic systems, and ensuring all work complies with safety and quality standards. Collaboration with other analysts, scientists, and quality assurance teams is common, particularly when optimizing analytical methods or supporting research and development projects. This dynamic and detail-oriented role plays an essential part in quality control, product development, and research within pharmaceutical, environmental, and chemical industries.

What are the key skills and qualifications needed to thrive in the High Performance Liquid Chromatography position, and why are they important?

To thrive in a High Performance Liquid Chromatography (HPLC) role, you need a solid background in chemistry, analytical techniques, and laboratory procedures, usually supported by a degree in chemistry, biochemistry, or a related field. Familiarity with HPLC instrumentation, chromatography software, and relevant quality and safety certifications such as GLP or GMP is highly beneficial. Attention to detail, strong problem-solving skills, and effective communication are valuable soft skills in this position. These skills and qualities ensure accurate analysis, regulatory compliance, and productive collaboration within laboratory settings.

What is a High Performance Liquid Chromatography job?

A High Performance Liquid Chromatography (HPLC) job typically involves analyzing and testing substances using HPLC techniques to separate, identify, and quantify compounds in a mixture. Professionals in this field, such as laboratory analysts or chemists, operate and maintain HPLC instruments, interpret results, and ensure compliance with industry standards. These roles are common in pharmaceutical, environmental, food, and chemical industries. Strong analytical skills, attention to detail, and knowledge of chromatography principles are essential for success in HPLC jobs.

More about High Performance Liquid Chromatography jobs
What cities are hiring for High Performance Liquid Chromatography jobs? Cities with the most High Performance Liquid Chromatography job openings:
What are the most commonly searched types of High Performance Liquid Chromatography jobs? The most popular types of High Performance Liquid Chromatography jobs are:
What states have the most High Performance Liquid Chromatography jobs? States with the most job openings for High Performance Liquid Chromatography jobs include:
What job categories do people searching High Performance Liquid Chromatography jobs look for? The top searched job categories for High Performance Liquid Chromatography jobs are:
Infographic showing various High Performance Liquid Chromatography job openings in the United States as of July 2026, with employment types broken down into 74% Full Time, 11% Part Time, 4% Temporary, 7% Contract, and 4% Nights. Highlights an 93% In-person, and 7% Remote job distribution, with an average salary of $99,528 per year, or $47.9 per hour.

$59K - $87K/yr

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Posted 21 days ago


Job description

POSITION SUMMARY:

This job is responsible for manufacturing and characterizing products using synthetic organic chemistry techniques while following manufacturing standard operating procedures (SOPs) and completing appropriate documentation.

DUTIES AND RESPONSIBILITIES: 

• Performs organic syntheses as instructed in SOPs to manufacture compounds for use in company products. 

• Monitors reactions in-process using High Performance Liquid Chromatography (HPLC) and Thin Layer Chromatography (TLC) to determine progress.

• Purifies reactions using size-exclusion chromatography, flash chromatography, and recrystallization to isolate desired compounds and measure process yields.

• Analyzes purified products by HPLC and TLC to determine levels of purity.

• Interprets Nuclear Magnetic Resonance (NMR) and Mass Spectrometer (MS) spectra to determine identity of synthesized compounds.

• Dispenses solutions into vials using automated dispensing equipment.

• Operates lyophilizers and automated crimping and labeling equipment to produce lyophilized vials.

• Participates in inventory control by issuing materials and completing work orders in JDEdwards.

• Completes appropriate documentation for all production procedures to including production batch records, work order forms, batch checklists, and product submission forms.

• Participates in general laboratory maintenance including maintaining laboratory cleanliness, supplies and equipment. 

• Participate in year-end physical inventory counting and regular cycle counting, to ensure financial accuracy of inventory.

EXPERIENCE AND QUALIFICATIONS:

• Bachelor’s degree in Chemistry or related field; or an Associate’s degree with equivalent applicable work experience.

• Internship experience in relative field is highly desirable

• Prior manufacturing experience is a plus.

KNOWLEDGE, SKILLS AND ABILITIES:

• Familiarity with organic chemistry techniques such as chromatography, rotary evaporation,  phase separations, High Performance Liquid Chromatography (HPLC), Nuclear Magnetic Resonance (NMR), and MS.  

• Knowledge of JDEdwards or other ERP system is preferred.

• Knowledge of cGMP and/or ISO certification is preferred.

• Ability to learn additional software applications/tools, as required.

• Ability to follow laboratory safety instructions; ability to use protective equipment.

• Knowledge of scientific fundamentals and strong analytical background. 

• Knowledge of  automated vialing or bottling equipment function and use is preferred.

o Mechanical aptitude including equipment troubleshooting

• Excellent oral, written communication and interpersonal skills. 

o Effectively communicate issues/problems and results that impact timelines, accuracy and reliability of laboratory data

• Proficiency in MS Office Suite. 

PHYSICAL DEMANDS:

• This position requires the ability to communicate and exchange information, utilize equipment necessary to perform the job, and frequent lifting up to 25 lbs.

• Up to 80% of the day may be spent at a lab bench and/or in the cleanroom

WORK ENVIRONMENT:

Standard industrial laboratory environment

COMPENSATION SUMMARY:

The annual base salary for this position ranges from $59,100 to $87,900. This salary range represents a general guideline as MSD considers other factors when presenting an offer of employment, such as scope and responsibilities of the position, external market factors, and the candidate’s knowledge, skills, abilities, education and experience. Employees may qualify for a discretionary or non-discretionary bonus in addition to their base salary. These annual bonuses are intended to recognize individual performance and enable employees to benefit from the Company's overall success.

BENEFITS SUMMARY:

At MSD, we offer a comprehensive benefits package to support our employees' well-being and financial security. In addition to competitive salaries, our benefits include medical, dental, and vision coverage, along with prescription benefits. We provide a 401(k) plan with company matching, flexible spending accounts, and company-paid short- and long-term disability insurance as well as group life and accidental death and dismemberment insurance. Our offerings also encompass paid vacation, paid sick leave, paid holidays, and paid parental leave, along with an employee assistance program. Additional voluntary perks include a fitness club membership contribution, pet insurance, identity theft protection, home and auto insurance discounts, and optional supplemental life insurance.

EEO/AA STATEMENT:

MSD is an Equal Opportunity/Affirmative Action Employer. We are committed to fostering a diverse and inclusive workplace where all individuals are treated with respect and dignity. We welcome applications from all qualified candidates, making employment decisions without regard to race, color, religion, creed, sex, sexual orientation, gender identity, genetic information, marital status, national origin, age, protected veteran status, pregnancy, disability status, or any other protected characteristic. For our full EEO/AA and Pay Transparency statement, please click on the following link: https://www.mesoscale.com/en/our_company/careers/equal_employment_opportunity_statement. 

Meso Scale Diagnostics uses E-Verify to validate the work eligibility of candidates.