Genomic Variant Scientist Jobs (NOW HIRING)

Join the forefront of groundbreaking research at the Beckman Research Institute of City of Hope, where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.

We are seeking an experienced and highly motivated Staff Scientist to join the Integrative Genomics Core. You will provide scientific leadership in the development, optimization, and execution of advanced genomics workflows. You will work closely with investigators to design experiments, implement new technologies, and ensure delivery of high-quality sequencing data. You will also contribute to strategic growth of the core by evaluating and deploying emerging genomics platforms and methodologies.

The Integrative Genomics Core provides comprehensive genomics services to support cutting-edge biomedical research. Leveraging advanced platforms such as Illumina, PacBio, Nanopore, and 10x Genomics, the core enables a broad range of genomic and epigenomic applications. These technologies empower investigators to explore complex biological systems, from cancer genomics to translational and precision medicine studies, within a highly collaborative, service-oriented environment.

As a successful candidate, you will:

         Provide design and consultation on genomic approaches with investigators, including study design, sample requirements, and technology selection

         Complete complex genomics workflows such as bulk, single-cell, and long-read sequencing applications

         Develop, optimize, and update current protocols for Illumina, PacBio, Nanopore, and 10x Genomics platforms

         Evaluate and implement emerging technologies to expand core capabilities

         Ensure quality control standards and best practices across all stages of sample processing and sequencing

         Communicate results to investigators; collaborate with bioinformatics teams on data analysis as needed

         Assist with grant applications, methods development, and collaborative publications where appropriate

         Train, mentor, and provide technical guidance to research staff and junior personnel

Your qualifications should include:

         Ph.D. in Genomics, Molecular Biology, Genetics, or a related field

         Minimum 3-5 years' experience in genomics or sequencing technologies

         Extensive hands-on experience across multiple sequencing platforms, including Illumina, PacBio, and 10x Genomics

         Expertise Expertise in library preparation for a variety of applications (RNA-seq, DNA-seq, ATAC-seq, ChIP-seq/CUT&RUN, methylation assays, and long-read sequencing); experience with single-cell and/or spatial genomics workflows (e.g., 10x Genomics Chromium, Visium)

         Strong understanding of genomics applications, including transcriptomics, epigenomics, and variant analysis

         Experience working in a core facility or shared resource environment with a strong service orientation

         Ability to develop, optimize, and validate wet-lab protocols and implement new technologies

         Demonstrated ability to troubleshoot complex experimental issues and improve workflow efficiency

         Strong mentoring and training experience for junior staff in laboratory techniques and best practices

         Excellent communication skills with experience consulting with investigators on experimental design and sample requirements

         Experience supporting collaborative research projects and contributing to methods sections of manuscripts or grants

City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location.

City of Hope is an equal opportunity employer.  

To learn more about our Comprehensive Benefits, please CLICK HERE.