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Full Time Scientific Software Developer Jobs (NOW HIRING)

The Affinity Group at OpenEye seeks to hire a scientific software developer to join a growing team delivering Molecular Dynamics (MD) based solutions for predicting protein-ligand binding affinities.

... science (especially parallel programming and code optimization), a strong mathematics/physics/engineering background, in-depth knowledge of computer software/hardware architecture, and excellent ...

... science (especially parallel programming and code optimization), a strong mathematics/physics/engineering background, in-depth knowledge of computer software/hardware architecture, and excellent ...

... science (especially parallel programming and code optimization), a strong mathematics/physics/engineering background, in-depth knowledge of computer software/hardware architecture, and excellent ...

The Affinity Group at OpenEye seeks to hire a scientific software developer to join a growing team delivering Molecular Dynamics (MD) based solutions for predicting protein-ligand binding affinities.

$101K - $188K/yr

... software, consulting services, and Orion, the only cloud-native fully integrated software-as-a ... Extend OpenEye's programming toolkits by developing and implementing new and useful scientific and ...

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Full Time Scientific Software Developer information

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How much do full time scientific software developer jobs pay per year?

As of Jun 21, 2026, the average yearly pay for full time scientific software developer in the United States is $102,500.00, according to ZipRecruiter salary data. Most workers in this role earn between $90,000.00 and $115,000.00 per year, depending on experience, location, and employer.

What are the typical collaboration patterns for a Full Time Scientific Software Developer within research teams?

As a Full Time Scientific Software Developer, you will frequently collaborate with scientists, data analysts, and other developers to translate research needs into robust software solutions. This often involves participating in regular meetings to discuss project goals, reviewing experimental data, and iteratively refining code based on user feedback. Clear communication and the ability to understand complex scientific concepts are essential, as you may be responsible for bridging the gap between scientific theory and practical implementation. Collaboration tools like version control systems and project management platforms are commonly used to facilitate teamwork and track progress.

What does a Full Time Scientific Software Developer do?

A Full Time Scientific Software Developer designs, develops, and maintains software applications used in scientific research and analysis. Their work often involves programming in languages like Python, C++, or MATLAB to create tools for data analysis, modeling, simulation, or visualization. They collaborate with scientists and researchers to understand their computational needs and translate them into robust, efficient software solutions. This role requires both strong software engineering skills and a solid understanding of the scientific domain they support.

What are the key skills and qualifications needed to thrive as a Full Time Scientific Software Developer, and why are they important?

To thrive as a Full Time Scientific Software Developer, you need strong programming skills (often in languages like Python, C++, or Java), a solid foundation in scientific computing, and typically a degree in computer science, physics, mathematics, or a related field. Experience with scientific libraries (e.g., NumPy, SciPy), version control systems (like Git), and familiarity with high-performance computing or cloud platforms are commonly required. Analytical thinking, problem-solving abilities, and effective communication are crucial soft skills for collaborating with researchers and conveying technical concepts. These skills and qualities are vital for developing reliable, efficient software solutions that advance scientific discovery and support interdisciplinary teams.
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Infographic showing various Full Time Scientific Software Developer job openings in the United States as of June 2026, with employment types broken down into 40% As Needed, and 60% Full Time. Highlights an 95% Physical, 1% Hybrid, and 4% Remote job distribution, with an average salary of $102,500 per year, or $49.3 per hour.
Scientific Software Developer - Affinity

Scientific Software Developer - Affinity

OpenEye Scientific

Santa Fe, NM • On-site

Full-time

Medical, Dental, Vision, Retirement, PTO

Posted 21 days ago


Job description

Over the last eight years, OpenEye Scientific has developed the field's most advanced large-scale compute platform, Orion, built on Amazon Web Services. In this position, you will be working at the cutting edge of cloud computing, C++/Python development, and advanced MD simulation techniques. Your work will have the potential to make a major impact in drug discovery, and will be available to many pharmaceutical and biotech companies.
OpenEye, Cadence Molecular Sciences, an industry leader in computational molecular design, uses a scientific approach to deliver rapid, robust, and scalable software, toolkits, and technology & design services for the advancement of pharmaceuticals, biologics, agrochemicals, and flavors and fragrances. We are passionate about science and about taking care of our team members, with leaders supporting your development and recognizing your contributions by providing an unmatched total compensation package in a collaborative, caring, energetic and fun work environment.
The Affinity Group at OpenEye seeks to hire a scientific software developer to join a growing team delivering Molecular Dynamics (MD) based solutions for predicting protein-ligand binding affinities. Within OpenEye's Cloud-based platform Orion, our team has already delivered to our clients massively parallel Relative Binding Free Energy (RBFE) tools capable of calculating affinities on dozens of ligands in only hours, using hundreds of GPUs. We are also developing faster, higher throughput MD-based prescreening approaches to use upstream of the heavier free energy methods. With your experience in MD and programming, you will help us to extend our capabilities in this area, making both our science and our tools better: more robust, more accurate, and more efficient. The work you do will have a high impact, contributing to the science of many organizations, both industry-based and academic. In this you will be collaborating with experienced scientific developers with expertise in small molecule drug discovery and long track records of delivering useful solutions and liaising with academic collaborators in the simulations community.
Please include a cover letter.
What you should have:
  • PhD. with PostDoc in an area related to structure-based ligand design methods.
  • 3 or more years of experience in scientific programming with Python.
  • 3 or more years of experience with Molecular Dynamics including Free Energy Calculations.
  • Experience in computational chemistry methods development, implementation, and validation
  • Team-oriented with good communication skills and professional scientific presentation skills.
  • Ability and desire to learn new ideas and adapt to new development practices

The following are a PLUS, but not required:
  • Knowledge & skill in programming and professional software development practices & tools
  • Experience with a multi platform and/or distributed computing environment including cloud computing.
  • Knowledge of chemistry and/or drug discovery & development

Benefits:
OpenEye is passionate about the welfare of its employees and offers competitive benefits that include medical, dental, vision, flexible working schedule, 401k retirement plans, paid vacation, paid sick leave, home internet costs, public transportation reimbursement, and much more.
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