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Full Time Downstream Process Development Scientist Jobs in Boston, MA

Amgen

Process Development Senior Scientist

Cambridge, MA · Hybrid

$100K - $136K/yr

Process Development Senior Scientist What you will do Let's do this. Let's change the world. In this vital role you will join our Drug Substance Technologies - Synthetics (DSTS) group at either our ...

King & Prince Seafood

Senior R&D Scientist

Gloucester, MA · On-site

$90K - $112K/yr

The Senior R&D Scientist independently leads projects, drives innovation initiatives, contributes ... Develop formulations, prototypes, processing strategies, and specifications that meet requirements ...

AT Process Technologies

Process Chemist

Waltham, MA · On-site

$130K - $200K/yr

Summary We are seeking a process development chemist to own and execute the research, development ... Develop and optimize core synthesis and downstream processing, evaluating competing technical ...

Amgen

Process Development Senior Scientist

Cambridge, MA

$100K - $136K/yr

Join us and transform the lives of patients while transforming your career Process Development Senior Scientist . What you will do Let's do this. Let's change the world. In this vital role you will ...

Zealandpharma

Global Head of Drug Substance

Cambridge, MA · On-site

$251K - $307K/yr

Develop and optimize upstream and downstream process design to establish scalable, cost-effective ... lab staffed with process scientists focused on hands-on peptide process development and ...

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All JobsDownstream Process Development Scientist JobsFull Time Downstream Process Development Scientist JobsFull Time Downstream Process Development Scientist Jobs in Boston, MA

Full Time Downstream Process Development Scientist information

See Boston, MA salary details

$22

$42

$66

How much do full time downstream process development scientist jobs pay per hour?

As of Aug 20, 2026, the average hourly pay for full time downstream process development scientist in Boston, MA is $42.00, according to ZipRecruiter salary data. Most workers in this role earn between $30.82 and $50.14 per hour, depending on experience, location, and employer.

What does a full time downstream process development scientist do?

A Full Time Downstream Process Development Scientist is responsible for designing, optimizing, and scaling up processes that purify biological products such as proteins, antibodies, or vaccines after they are produced in cells or microbes. This role involves developing and improving techniques like filtration, chromatography, and centrifugation to ensure high purity and yield of the final product. The scientist also conducts experiments, analyzes data, and collaborates with cross-functional teams to transfer processes from the lab to manufacturing. Their work is critical for producing safe and effective biopharmaceuticals on a large scale.

What are the key skills and qualifications needed to thrive as a full time downstream process development scientist, and why are they important?

To thrive as a Full Time Downstream Process Development Scientist, you need a strong background in biochemical engineering, protein purification, and analytical techniques, typically supported by a degree in biochemistry, biotechnology, or a related field. Proficiency with chromatography systems (e.g., HPLC, FPLC), filtration technologies, and knowledge of regulatory and quality systems like GMP is essential. Strong problem-solving abilities, teamwork, and effective communication skills help you collaborate with cross-functional teams and troubleshoot process challenges. These skills are crucial for developing robust purification processes that ensure product quality, regulatory compliance, and efficient production in biopharmaceutical environments.

What are some typical challenges faced by a full time downstream process development scientist, and how can they be addressed?

Downstream Process Development Scientists often encounter challenges such as optimizing protein purification processes to achieve high yield and purity, troubleshooting unexpected impurities, and scaling up processes from laboratory to manufacturing scale. These tasks require strong problem-solving skills, meticulous attention to detail, and effective collaboration with upstream teams, analytical scientists, and manufacturing staff. Addressing these challenges involves staying current with new purification technologies, maintaining robust documentation, and participating in cross-functional meetings to ensure seamless process integration and regulatory compliance.

What is the difference between Full Time Downstream Process Development Scientist vs Downstream Process Engineer?

AspectFull Time Downstream Process Development Scientist
Primary FocusDesigning, optimizing, and developing downstream purification processes for biopharmaceuticals
Required CredentialsBachelor's or Master's in Biotechnology, Biochemistry, or related field; experience in process development
Work EnvironmentLaboratories, R&D settings, collaborative teams in biotech or pharma companies
Typical ResponsibilitiesProcess scale-up, method validation, troubleshooting, documentation

While both roles involve downstream bioprocessing, the Full Time Downstream Process Development Scientist focuses on process development and optimization, whereas the Downstream Process Engineer typically handles process implementation and manufacturing support. The scientist role emphasizes research and development, while the engineer role is more operational. Candidates often hold similar degrees and certifications, but their daily tasks and focus areas differ.

How much does a full time downstream process development scientist make?

In California, a full-time downstream process development scientist typically earns between $80,000 and $130,000 annually, depending on experience, education, and the specific employer. Salaries may also include benefits such as health insurance and bonuses, with higher compensation often associated with advanced skills in bioprocessing and laboratory techniques.

What is a full time downstream process development scientist?

A full-time downstream process development scientist specializes in designing, optimizing, and scaling the purification processes used in biopharmaceutical manufacturing, such as chromatography and filtration. They work to improve product yield, purity, and efficiency, often using laboratory techniques and process modeling tools, typically within a regulated environment requiring compliance with industry standards.

What are the most commonly searched types of Downstream Process Development Scientist jobs in Boston, MA?

The most popular types of Downstream Process Development Scientist jobs in Boston, MA are:

What are popular job titles related to Full Time Downstream Process Development Scientist jobs in Boston, MA?

For Full Time Downstream Process Development Scientist jobs in Boston, MA, the most frequently searched job titles are:

What job categories do people searching Full Time Downstream Process Development Scientist jobs in Boston, MA look for?

The top searched job categories for Full Time Downstream Process Development Scientist jobs in Boston, MA are:

Full Time Downstream Process Development Scientist jobs near you

Senior Scientist I, Quality Control

Candel Therapeutics

Needham, MA • On-site

$155K - $160K/yr

Full-time

Re-posted 29 days ago

Job description

Salary $155K - $160K
On site role in Needham
Senior Scientist I, Quality Control is responsible for executing highly complex analytical assays supporting clinical and commercial programs. This position collaborates with external manufacturing and tech transfer and is focused on Adenovirus and Herpesvirus vectors, associated cell-based potency assays, as well as performing training of new technical staff and troubleshooting and validation of new and established assays. The Senior Scientist I, Quality Control works with various cell lines, performs analytical methods, trends quality attributes, and suitability of product lines for continued use.
Essential Areas of Responsibility:
  • Participate in the development of cell culture and viral vector production using Adenovirus and Herpesvirus production systems.
  • Function as subject matter expert (SME) for technical platforms and new methodologies.
  • Perform assays in support of process development including cell-based assays, ELISA, HPLC, qPCR, SDS-PAGE, UV-spectroscopy.
  • Generate, manage, evaluate, and maintain critical data in a highly organized manner and document in paper or Electronic Laboratory notebook.
  • Participate in the development, optimization, and validation of new assays.
  • Assist with the development of SOPs and batch records for use in Quality Control, or external CMOs.
  • Interact with other departments such as Analytical development, Quality Assurance, Regulatory Affairs, Research, Upstream and Downstream Process Development.
  • Contribute to laboratory support duties associated with operating a QC laboratory.
  • Guide, direct, and train direct reports and team members, including performance monitoring, constructive feedback, quality standards, etc.
  • Able to react to change productively and handle other essential tasks as assigned.

Minimum Education, Experience and Skill Requirements:
Education:
  • PhD or equivalent in biology, chemistry, biochemistry, or related field plus applicable experience. (Internship and/or post-doctoral experience is also accepted)

Experience:
  • Hands-on experience with aseptic techniques related to mammalian cell culture (Vero and HEK293 cells lines)
  • Hands-on experience in laboratory techniques supporting virus, protein and DNA analysis: SDS-PAGE, Western Blot, BCA, residual DNA, HPLC, ELISA.
  • Willingness to learn (new methods, drug development processes, new modalities, etc.) and ability to demonstrate scientific curiosity and innovation.
  • Previous experience in small biotech/pharma company.
  • Previous experience working with viruses.
  • Ability to work independently.
  • Familiarity with basic regulatory expectations around product control strategies and the ICH guidelines for method qualification.
  • Familiarity with Drug Substance and Drug Product release and stability testing programs.
  • A strong background in one or more analytical techniques such as various HPLC based methods, microplate UV/Vis/Luminescent assays, cell-based assays including virus quantification and potency, qPCR, electrophoresis, sizing techniques such as DLS, etc.
  • Ability to write technical documents, including but not limited to method SOPs, development reports, qualification reports, method transfer protocols and method transfer report.
  • Functional understanding of GxP principles.
  • Strong computer skills and good verbal and written communication skills.
  • Very good collaboration and team building skills.

Must be authorized to work in the US. No sponsorships available.
We are not accepting resumes from agencies at this time.

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