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Full Time Downstream Process Development Scientist Jobs in Boston, MA

Takeda

Downstream Engineer III

Lexington, MA · On-site

The Downstream Process Development Engineer III is responsible for supporting downstream ... Locations Lexington, MA Worker Type Employee Worker Sub-Type Regular Time Type Full time Job Exempt ...

CEDENT

Senior Scientist, Process Development

Watertown, MA · On-site

$99K - $135K/yr

We are seeking a Senior Scientist, Process Development, responsible for executing cell culture experiments, downstream processing, analyzing data, and contributing to process development projects.

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All JobsDownstream Process Development Scientist JobsFull Time Downstream Process Development Scientist JobsFull Time Downstream Process Development Scientist Jobs in Boston, MA

Full Time Downstream Process Development Scientist information

See Boston, MA salary details

$22

$42

$66

How much do full time downstream process development scientist jobs pay per hour?

As of Aug 7, 2026, the average hourly pay for full time downstream process development scientist in Boston, MA is $42.00, according to ZipRecruiter salary data. Most workers in this role earn between $30.82 and $50.14 per hour, depending on experience, location, and employer.

What does a full time downstream process development scientist do?

A Full Time Downstream Process Development Scientist is responsible for designing, optimizing, and scaling up processes that purify biological products such as proteins, antibodies, or vaccines after they are produced in cells or microbes. This role involves developing and improving techniques like filtration, chromatography, and centrifugation to ensure high purity and yield of the final product. The scientist also conducts experiments, analyzes data, and collaborates with cross-functional teams to transfer processes from the lab to manufacturing. Their work is critical for producing safe and effective biopharmaceuticals on a large scale.

What is the difference between Full Time Downstream Process Development Scientist vs Downstream Process Engineer?

AspectFull Time Downstream Process Development Scientist
Primary FocusDesigning, optimizing, and developing downstream purification processes for biopharmaceuticals
Required CredentialsBachelor's or Master's in Biotechnology, Biochemistry, or related field; experience in process development
Work EnvironmentLaboratories, R&D settings, collaborative teams in biotech or pharma companies
Typical ResponsibilitiesProcess scale-up, method validation, troubleshooting, documentation

While both roles involve downstream bioprocessing, the Full Time Downstream Process Development Scientist focuses on process development and optimization, whereas the Downstream Process Engineer typically handles process implementation and manufacturing support. The scientist role emphasizes research and development, while the engineer role is more operational. Candidates often hold similar degrees and certifications, but their daily tasks and focus areas differ.

What are some typical challenges faced by a full time downstream process development scientist, and how can they be addressed?

Downstream Process Development Scientists often encounter challenges such as optimizing protein purification processes to achieve high yield and purity, troubleshooting unexpected impurities, and scaling up processes from laboratory to manufacturing scale. These tasks require strong problem-solving skills, meticulous attention to detail, and effective collaboration with upstream teams, analytical scientists, and manufacturing staff. Addressing these challenges involves staying current with new purification technologies, maintaining robust documentation, and participating in cross-functional meetings to ensure seamless process integration and regulatory compliance.

What are the key skills and qualifications needed to thrive as a full time downstream process development scientist, and why are they important?

To thrive as a Full Time Downstream Process Development Scientist, you need a strong background in biochemical engineering, protein purification, and analytical techniques, typically supported by a degree in biochemistry, biotechnology, or a related field. Proficiency with chromatography systems (e.g., HPLC, FPLC), filtration technologies, and knowledge of regulatory and quality systems like GMP is essential. Strong problem-solving abilities, teamwork, and effective communication skills help you collaborate with cross-functional teams and troubleshoot process challenges. These skills are crucial for developing robust purification processes that ensure product quality, regulatory compliance, and efficient production in biopharmaceutical environments.
What are the most commonly searched types of Downstream Process Development Scientist jobs in Boston, MA? The most popular types of Downstream Process Development Scientist jobs in Boston, MA are:
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Full Time Downstream Process Development Scientist jobs near you

Scientist I Process Development - Upstream or Downstream

Thermo Fisher Scientific

Plainville, MA

$28.16 - $42.24/hr

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Posted 3 days ago

New

Thermo Fisher Scientific rating

7.7

Company rating: 7.7 out of 10

Based on 422 frontline employees who took The Breakroom Quiz

196th of 536 rated manufacturers

Job description

Work Schedule

Standard (Mon-Fri)

Environmental Conditions

Laboratory Setting, Office, Standing for full shift

Job Description

Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue exceeding $35 billion. Whether our customers are accelerating life sciences research, solving complex analytical challenges, improving patient diagnostics and therapies or increasing efficiency in their laboratories, we are here to support them.

At Viral Vector Services (VVS) a division of Thermo Fisher Scientific, we deliver from process development through commercial supply, we offer the expertise and resources to help clients deliver innovative gene therapies.

Job Title: Scientist I Process Development-Upstream or Downstream

Location/Division Specific Information: US - Massachusetts – Plainville (on-site)

How will you make an impact?

As the Upstream/Downstream Process Development Scientist you will help our clients to deliver lifesaving and life changing therapies to patients in need. You will be supporting planning, executing, and documenting laboratory and tech transfer activities in support of process establishment, pilot, and transfer into cGMP manufacturing. You will also act as a subject matter expert (SME) and support transfer and operation of internally developed and client-transferred processes into the process development and pilot space. You will also be supporting tech transfer out to the cGMP manufacturing space.  

Education regiments:

B.S. in Chemical Engineering, Biochemistry, Biology or related field

General qualifications:

  • Demonstrated understanding of experimental design with the ability to independently conduct laboratory experiments.
  • Collaborate with the Analytical Development team to develop comprehensive testing plans.
  • Participate in client meetings to present results and assist with drafting process development reports.
  • Prepare Process Development records, work instructions, and batch records.
  • Proficiency in technical writing, adhering to Good Documentation Practices (GDP), with preferred experience in data compilation and interpretation.
  • Strong communication skills with the ability to clearly and concisely interpret, summarize, and present scientific data.
  • Flexibility in work hours, including availability for weekends and evenings, as the need arises to meet project timelines.

Upstream Process Development Qualifications:

  • Practical experience in aseptic techniques, cell culture, single-use bioreactors (SUBs), wave reactors, and harvest/clarification processes is preferred. Familiarity with transfection and infection -based processes for gene therapy production

Downstream Process Development Qualifications:

  • Expertise in various purification techniques, including affinity and anion exchange chromatography, with proficiency in using AKTA chromatography systems and Unicorn software is helpful. Experience with filtration-based unit operations such as tangential flow filtration, sterile filtration, and depth filtration is helpful.

Knowledge, Skills, Abilities

  • Ability to analyze and summarize scientific data
  • Understanding of cGMP and regulatory requirements of biopharmaceutical manufacturing.
  • Strong interpersonal and communications skills; written and oral
  • Ability to function in a constantly evolving environment & balance multiple priorities.
  • A flexible work schedule is required including Weekend and night as needed to support lab activities.

At Thermo Fisher Scientific, each one of our 70,000 extraordinary minds have a unique story to tell. Join us and contribute to our singular mission—enabling our customers to make the world healthier, cleaner and safer.

Apply today! http://jobs.thermofisher.com

Thermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate since race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other legally protected status.

Compensation and Benefits

The hourly pay range estimated for this position based in Massachusetts is $28.16–$42.24.

This position may also be eligible to receive a variable annual bonus based on company, team, and/or individual performance results in accordance with company policy. We offer a comprehensive Total Rewards package that our U.S. colleagues and their families can count on, which includes:

  • A choice of national medical and dental plans, and a national vision plan, including health incentive programs

  • Employee assistance and family support programs, including commuter benefits and tuition reimbursement

  • At least 120 hours paid time off (PTO), 10 paid holidays annually, paid parental leave (3 weeks for bonding and 8 weeks for caregiver leave), accident and life insurance, and short- and long-term disability in accordance with company policy

  • Retirement and savings programs, such as our competitive 401(k) U.S. retirement savings plan

  • Employees’ Stock Purchase Plan (ESPP) offers eligible colleagues the opportunity to purchase company stock at a discount

For more information on our benefits, please visit: https://jobs.thermofisher.com/global/en/total-rewards

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