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Full Time Downstream Process Development Scientist Jobs in Boston, MA

Amgen

Process Development Senior Scientist

Cambridge, MA · On-site

$100K - $136K/yr

Process Development Senior Scientist What you will do Let'sdo this.Let'schange the world. In this vital role you willbe responsible fordevelopment, characterization, scale-up and support of drug ...

PREDICTA BIOSCIENCES INC

R&D Scientist

Cambridge, MA

... downstream NGS library preparation and sequencing, translating early research concepts into ... Develop and optimize sample processing workflows (whole blood, bone marrow, PBMC isolation) that ...

Predicta Biosciences

R&D Scientist

Cambridge, MA · On-site

... downstream NGS library preparation and sequencing, translating early research concepts into ... Develop and optimize sample processing workflows (whole blood, bone marrow, PBMC isolation) that ...

Predicta Biosciences

R&D Scientist

Cambridge, MA · On-site

... downstream NGS library preparation and sequencing, translating early research concepts into ... Develop and optimize sample processing workflows (whole blood, bone marrow, PBMC isolation) that ...

Amgen

Process Development Senior Scientist

Cambridge, MA · Hybrid

$100K - $136K/yr

Process Development Senior Scientist What you will do Let's do this. Let's change the world. In this vital role you will join our Drug Substance Technologies - Synthetics (DSTS) group at either our ...

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All JobsDownstream Process Development Scientist JobsFull Time Downstream Process Development Scientist JobsFull Time Downstream Process Development Scientist Jobs in Boston, MA

Full Time Downstream Process Development Scientist information

See Boston, MA salary details

$22

$42

$66

How much do full time downstream process development scientist jobs pay per hour?

As of Aug 7, 2026, the average hourly pay for full time downstream process development scientist in Boston, MA is $42.00, according to ZipRecruiter salary data. Most workers in this role earn between $30.82 and $50.14 per hour, depending on experience, location, and employer.

What does a full time downstream process development scientist do?

A Full Time Downstream Process Development Scientist is responsible for designing, optimizing, and scaling up processes that purify biological products such as proteins, antibodies, or vaccines after they are produced in cells or microbes. This role involves developing and improving techniques like filtration, chromatography, and centrifugation to ensure high purity and yield of the final product. The scientist also conducts experiments, analyzes data, and collaborates with cross-functional teams to transfer processes from the lab to manufacturing. Their work is critical for producing safe and effective biopharmaceuticals on a large scale.

What is the difference between Full Time Downstream Process Development Scientist vs Downstream Process Engineer?

AspectFull Time Downstream Process Development Scientist
Primary FocusDesigning, optimizing, and developing downstream purification processes for biopharmaceuticals
Required CredentialsBachelor's or Master's in Biotechnology, Biochemistry, or related field; experience in process development
Work EnvironmentLaboratories, R&D settings, collaborative teams in biotech or pharma companies
Typical ResponsibilitiesProcess scale-up, method validation, troubleshooting, documentation

While both roles involve downstream bioprocessing, the Full Time Downstream Process Development Scientist focuses on process development and optimization, whereas the Downstream Process Engineer typically handles process implementation and manufacturing support. The scientist role emphasizes research and development, while the engineer role is more operational. Candidates often hold similar degrees and certifications, but their daily tasks and focus areas differ.

What are some typical challenges faced by a full time downstream process development scientist, and how can they be addressed?

Downstream Process Development Scientists often encounter challenges such as optimizing protein purification processes to achieve high yield and purity, troubleshooting unexpected impurities, and scaling up processes from laboratory to manufacturing scale. These tasks require strong problem-solving skills, meticulous attention to detail, and effective collaboration with upstream teams, analytical scientists, and manufacturing staff. Addressing these challenges involves staying current with new purification technologies, maintaining robust documentation, and participating in cross-functional meetings to ensure seamless process integration and regulatory compliance.

What are the key skills and qualifications needed to thrive as a full time downstream process development scientist, and why are they important?

To thrive as a Full Time Downstream Process Development Scientist, you need a strong background in biochemical engineering, protein purification, and analytical techniques, typically supported by a degree in biochemistry, biotechnology, or a related field. Proficiency with chromatography systems (e.g., HPLC, FPLC), filtration technologies, and knowledge of regulatory and quality systems like GMP is essential. Strong problem-solving abilities, teamwork, and effective communication skills help you collaborate with cross-functional teams and troubleshoot process challenges. These skills are crucial for developing robust purification processes that ensure product quality, regulatory compliance, and efficient production in biopharmaceutical environments.
What are the most commonly searched types of Downstream Process Development Scientist jobs in Boston, MA? The most popular types of Downstream Process Development Scientist jobs in Boston, MA are:
What are popular job titles related to Full Time Downstream Process Development Scientist jobs in Boston, MA? For Full Time Downstream Process Development Scientist jobs in Boston, MA, the most frequently searched job titles are:
What job categories do people searching Full Time Downstream Process Development Scientist jobs in Boston, MA look for? The top searched job categories for Full Time Downstream Process Development Scientist jobs in Boston, MA are:
Full Time Downstream Process Development Scientist jobs near you

Engineer, Biologics Purification, Upstream/Downstream/Tech Transfer - Remote (JP15407)

3 Key Consulting

Cambridge, MA • On-site, Remote

$34 - $37/hr

Full-time

Re-posted 18 days ago

Job description

Job Title: Engineer, Biologics Purification, Upstream/Downstream/Tech Transfer - Remote (JP15407)
Location: Cambridge MA, Remote
Employment Type: Contract
Business Unit: Drug Substance Technology Engineering Group
Duration: 1+ years with possible extensions and/or conversion to permanent
Posting Date: 5/21/2026
Pay Rate: $34 - $37/hour W2
Notes: Remote (Any TZ - Local to Cambridge, MA is highly preferred.
 
3 Key Consulting is hiring an Engineer for a consulting engagement with our direct client, a leading global biopharmaceutical company.
Job Description:
Seeking a Process Development Engineer to join the Drug Substance Technology Engineering team at our client Cambridge site. Providing strong process engineering/ technology transfer support of human therapeutic drug substance products in clinical development through commercial production. Our mission is to translate developmental processes to commercial reality for patients through scientific expertise and engineering innovation. Knowledge of processes/equipment; scale-up factors, process deviations, quality attributes. GMP experience is a plus.
The Engineer will apply upstream and downstream process engineering knowledge in support of technology transfer and clinical/commercial drug substance manufacturing in both stainless and single-use formats. Will partner with manufacturing, quality, analytical, and bench scientists to support a highly dynamic technology transfer.
JOB RESPONSIBILITIES:
Under guidance of senior staff, the Engineer will perform the following:
  • Transfer processes for drug substance manufacturing and translate process improvements from the laboratory into manufacturing facilities
  • Provide technical support for successful scale-up, transfer of process technology, and for clinical and/or commercial manufacturing operation. Experience is technical report writing an expectation.
  • Assist in troubleshooting clinical and commercial runs
  • Execute data trending and statistical process analysis
  • Support technical direction for process-related deviations, CAPAs, and change controls
  • Identify and support process-related operational excellence opportunities
  • Represent process development and collaborates with other functions such as Manufacturing, Quality, and Regulatory.
  • Experience related to Process characterization for manufacturing of biologics highly preferred. This includes technical support for authoring and review of process characterization reports.

Why is the Position Open?
Supplement additional workload on team.
BASIC QUALIFICATIONS:
Master’s degree and 2 years of Engineering or Operations experience
Bachelor’s degree and 4 years of Engineering or Operations experience
Associate’s degree and 7 years of Engineering or Operations experience
High school diploma / GED and 8 years of Engineering or Operations experience
PREFERRED QUALIFICATIONS:
  • Master’s Degree in Chemical or Biochemical Engineering
  • 2+ years of Process Engineering experience preferably related to downstream/ purification of commercial cGMP manufacturing facilities
  • Background in biologics technology transfer into commercial facilities, new product introductions (NPIs)
  • Biologics purification process knowledge: Knowledge of upstream ( cell culture/bioreactor operations) or purification processes (chromatography, viral filtration/inactivation, ultrafiltration/diafiltration, and final fill. )/ equipment; scale-up factors, process deviations, quality attributes
  • Strong analytical capability, troubleshooting, and problem solving
  • Independently motivated with ability to multi-task and work in teams, especially if remote or hybrid.
  • Excellent written and verbal communication skills with technical writing and presentation experience. Experience in PC documentation, report reviews and technical writing preferred.
     
Top Must Have Skills:
  • Cell culture experience, Purification /downstream experience, process characterization experience
  • Nice to have:
    Monoclonal antibodies or mAbs 
    manufacturing or on floor support 

Day to Day Responsibilities:
Assist senior staff in technical writing, process tech transfer, data monitoring
Red Flags:
No experience, not enough experience in biopharma or biotech, no experience in cell culture/upstream, purification/downstream or technical report writing
Interview process:
Teams interview. Screening 30 minute Microsoft team's interview with me. Second round- Team's interview 30 minute each approximately with 3 other team members.
We invite qualified candidates to send your resume to resumes@3keyconsulting.com.  If you decide that you’re not interested in pursuing this particular position, please feel free to take a look at the other positions on our website www.3keyconsulting.com/careers. You are also welcome to share this opportunity with anyone you think might be interested in applying for this role.