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Classification Title:

Postdoctoral Associate

Classification Minimum Requirements: Qualified applicants should have completed a relevant Ph.D. degree in structural biology, chemical biology, or organic/medicinal chemistry. Job Description:

Effective immediately, the Disney group in the Department of Chemistry at The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology (https://disney.scripps.ufl.edu) is seeking to hire a Postdoctoral Associate in RNA Chemical Biology.

Lab Overview:

The Disney group is a chemical biology laboratory focused on developing rational approaches to design highly selective therapeutics from only genome sequence. Known for its prolific output and pioneering research culture, the group has furthered advancements in annotating RNA structure from sequence alongside several novel technologies created in-house. The laboratory's targeting of RNA by small molecules, an ambitious and highly focused enterprise in pursuit of chemical probe and lead medicine development, is summarized in Nature Reviews Drug Discovery (2023) 618(7963): 169-179.

Other representative publications from the Disney group include:

Studying disease mediated by RNA repeat expansions that cause genetically defined ALS and dementia:

o Science Translation Medicine (2021) 13:eabd5991; doi: 10.1126/scitranslmed.abd5991

o Neuron (2014) 83:1043-50; doi: 10.1016/j.neuron.2014.07.041

o Cell Chemical Biology (2019) 26:179-190; doi: 10.1016/j.chembiol.2018.10.018

Targeted RNA degradation and related technologies:

o Nature Reviews Drug Discovery (2023) 618(7963): 169-179; doi: 10.1038/s41586-023-06091-8

o Journal of the American Chemical Society (2021) 143:13044-13055; doi: 10.1021/jacs.1c02248

o Science Translation Medicine (2021) 13:eabd5991; doi: 10.1126/scitranslmed.abd5991

o Proceedings of the National Academy of Sciences USA (2020) 117:2406-2411; doi: 10.1073/pnas.1914286117

o Proceedings of the National Academy of Sciences USA (2019) 116:7799-7804; doi: 10.1073/pnas.1901484116

o Journal of the American Chemical Society (2018) 140:6741-6744; doi: 10.1021/jacs.8b01233

o Nature Chemical Biology (2017) 13:188-193; doi: 10.1038/nchembio.225

Precision targeted therapeutics for difficult-to-treat cancers and other diseases:

o Journal of the American Chemical Society (2019) 141:2960-2974; doi: 10.1021/jacs.8b10558

o Cell Chemical Biology (2018) 25:1086-1094; doi: 10.1016/j.chembiol.2018.05.01

o Proceedings of the National Academy of Sciences USA (2016) 113:5898-903; doi: 10.1073/pnas.1523975113

o Proceedings of the National Academy of Sciences USA (2020) 117:1457-1467; doi: 10.1073/pnas.190505711

Our Commitment: The Disney group is highly committed to each individual's professional development during his or her time in the lab. A high impact research project and training plan to support the achievement of short-term as well as long-term career goals is customized for each student.

Expected Salary:

Commensurate with experience. 

Required Qualifications:

Qualified applicants should have completed a relevant Ph.D. degree in structural biology, chemical biology, or organic/medicinal chemistry.

Preferred:

Preference will be given to candidates with strong skills in RNA biology techniques, molecular biology, and biochemical methods. Previous experience with RNA-seq data analysis, DNA encoded library design and screening, and structure-based design is also desirable. 

Highly motivated candidates possessing a strong academic track-record, a high-impact publication list, a team-player mentality, and an interest in targeting the RNA world are poised for success in the group. 

The Disney group employs a broad range of experimental techniques, and thus a wide set of research skills is preferable, and a willingness to learn new methods is essential. 

Special Instructions to Applicants:

In order to be considered, you must upload your cover letter and resume.

The final candidate will be required to provide official transcript to the hiring department upon hire. A transcript will not be considered "official" if a designation of "Issued to Student" is visible. Degrees earned from an education institution outside of the United States are required to be evaluated by a professional credentialing service provider approved by National Association of Credential Evaluation Services (NACES), which can be found at http://www.naces.org/.

Please provide names and email addresses of three to five references as part of the UF application process. When ready, the hiring department will contact the listed references via email requesting their reference letters to be uploaded directly to the application website.

This position is open until filled. Application review will begin May 29, 2026. 

This is a time-limited position. 

This requisition is being used to fill multiple positions.  

The University of Florida is a member of the State University System of Florida and an Equal Opportunity Employer. All qualified applicants will receive consideration for employment based on merit.
If an accommodation due to a disability is needed to apply for this position, please call 352-392-2477 or the Florida Relay System at 800-955-8771 (TDD) or visit Accessibility at UF.

Health Assessment Required: No.