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Freelance Cryo Electron Microscopy Jobs (NOW HIRING)

Cogent Scientific

Expert Pharma Biochemist

Louisville, CO · On-site

$40K - $54K/yr

Preparing and optimizing samples for single-particle cryo-electron microscopy (cryo-EM): complex assembly, negative-stain/grid screening, vitrification, and iterative optimization. * Coordinating ...

Cogent Scientific

Expert Pharma Biochemist

Louisville, CO · On-site

$120 - $170/hr

Preparing and optimizing samples for single-particle cryo-electron microscopy (cryo-EM): complex assembly, negative-stain/grid screening, vitrification, and iterative optimization. * Coordinating ...

Cogent Scientific

Expert Pharma Biochemist

Louisville, CO · On-site

$40K - $54K/yr

Preparing and optimizing samples for single-particle cryo-electron microscopy (cryo-EM): complex assembly, negative-stain/grid screening, vitrification, and iterative optimization. * Coordinating ...

Cogent Scientific

Expert Pharma Biochemist

Louisville, CO · On-site

$115K - $125K/yr

Preparing and optimizing samples for single-particle cryo-electron microscopy (cryo-EM): complex assembly, negative-stain/grid screening, vitrification, and iterative optimization. * Coordinating ...

University of Colorado

Post-Doctoral Fellow

Aurora, CO · On-site

$49K - $67K/yr

By employing high-resolution cryo-electron microscopy (cryo-EM) and tomography (cryo-ET), we aim to capture the transient, high-order assemblies that trigger signaling in response to stress. In ...

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Freelance Cryo Electron Microscopy information

What is freelance cryo electron microscopy?

Freelance cryo electron microscopy (cryo-EM) involves providing specialized microscopy services on a contract or project basis, rather than as a full-time employee. Cryo-EM is a technique used to visualize biological molecules at near-atomic resolution by rapidly freezing samples and imaging them using electron microscopy. Freelancers in this field may assist academic labs, biotech companies, or pharmaceutical firms with sample preparation, data collection, and image analysis. This role often requires advanced training in cryo-EM instrumentation and data interpretation, as well as familiarity with the latest software and imaging protocols.

What are the key skills and qualifications needed to thrive as a freelance cryo electron microscopy specialist?

To thrive as a Freelance Cryo Electron Microscopy Specialist, you need a solid background in structural biology, electron microscopy techniques, and a relevant degree such as a PhD or MSc in life sciences. Proficiency with cryo-EM instruments, sample preparation protocols, and image processing software like RELION or cryoSPARC is typically required. Strong problem-solving abilities, attention to detail, and effective communication skills help in collaborating with clients and interpreting complex data. These competencies are crucial for producing high-quality results, meeting project deadlines, and delivering valuable insights in a competitive scientific field.

What are some typical challenges freelance cryo electron microscopy specialists face when collaborating with research teams remotely?

Freelance Cryo-EM specialists often encounter challenges such as coordinating schedules across different time zones, ensuring secure and efficient transfer of large datasets, and maintaining clear communication with research teams on project goals and progress. Additionally, troubleshooting instrument or sample preparation issues can be more complex without onsite access. However, successful freelancers leverage remote collaboration tools, transparent project management, and regular updates to overcome these hurdles and deliver high-quality results.

What is the difference between Freelance Cryo Electron Microscopy vs Freelance Transmission Electron Microscopy?

AspectFreelance Cryo Electron MicroscopyFreelance Transmission Electron Microscopy
CredentialsAdvanced degree in biology, chemistry, or materials science; microscopy trainingSimilar credentials; microscopy training required
Work EnvironmentLaboratories, research facilities, field sitesLaboratories, research institutions
Industry UsageStructural biology, nanotechnology, materials scienceMaterials science, nanotechnology, semiconductor research

Both freelance roles require specialized microscopy skills and similar educational backgrounds. Cryo Electron Microscopy focuses on imaging biological samples at cryogenic temperatures, while Transmission Electron Microscopy is used for a broader range of materials, including inorganic and biological specimens. The choice depends on the specific industry and sample type.

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Freelance Cryo Electron Microscopy jobs near you
Infographic showing various Freelance Cryo Electron Microscopy job openings in the United States as of August 2026, with employment types broken down into 56% Full Time, 15% Part Time, 2% Temporary, and 27% Contract. Highlights an 61% Physical, 3% Hybrid, and 36% Remote job distribution.

Research Associate II, Structural & Cellular Biology (Proteomics & CryoET)

Biohub

Redwood City, CA • On-site, Remote

Full-time

Retirement, PTO

Posted 23 days ago

Key responsibilities

  • Maintain, seed, and harvest human iPSC and mammalian cell lines for proteomics and imaging workflows.

  • Prepare samples for proximity labeling, immunoprecipitation, crosslinking mass spectrometry, cryoET, and CLEM experiments.

  • Assist with cryo FIB milling, cryoET data collection, tomogram reconstruction, and visualization.

Job description

Biohub is the first large-scale initiative bringing frontier AI models, massive compute, and frontier experimental capabilities under one roof. We're building a general-purpose system to accelerate scientific discovery, integrating frontier AI models, biological foundation models, and lab capabilities, with the ultimate goal of curing disease. Our technology powers scientists around the world, translating AI capabilities into tools that accelerate research everywhere.
The Team
The Biohub is a group of nonprofit research institutes that bring together scientists, engineers, and physicians with the goal of pursuing grand scientific challenges on 10- to 15-year time horizons. The Biohub focuses on understanding underlying mechanisms of disease and developing new technologies that will lead to actionable diagnostics and effective therapies.
Our Vision
  • We pursue large scientific challenges that cannot be pursued in conventional environments
  • We enable individual investigators to pursue their riskiest and most innovative ideas
  • The technologies developed at the Biohub facilitate research by scientists and clinicians at our home institutions and beyond
    Diversity of thought, ideas, and perspectives are at the heart of Biohub and enable disruptive innovation and scholarly excellence. We are committed to cultivating an organization where all colleagues feel inspired and know their work makes an important contribution.

This role sits at the interface of two closely connected efforts within our Dynamic Structural Biology group, which maps the molecular architecture of living cells - charting how protein complexes assemble, where they localize, and how their organization shifts across cell states and in response to perturbation. We develop and operate advanced imaging workflows to resolve the structure of signaling organelles such as primary cilia and lysosomes. Together we develop and deploy cutting-edge cryo-electron tomography, proteomics, and correlative imaging approaches in mammalian cell line models to connect molecular interactomes to cellular architecture, function, and disease.
The Opportunity
Biohub is seeking a skilled and motivated Research Associate II to support our structural and cellular biology programs across proteomics and cryo-electron tomography. This is a hands-on bench role at the intersection of stem cell and mammalian cell biology, genome engineering, proteomics technology development, and advanced cryo-electron microscopy. You will maintain and engineer cell lines, design and optimize sample-preparation workflows for both mass spectrometry and cryoET, and help implement proximity labeling, crosslinking, correlative light and electron microscopy (CLEM), and FIB-SEM lamella preparation to map protein interaction networks and cellular architecture.
This position is well suited for candidates who enjoy hands-on experimental work, thrive in collaborative and fast-paced research environments, and are excited to contribute to biological discovery through the development and operation of advanced proteomics and imaging workflows. You will work closely with other scientists of diverse backgrounds in a fast-moving, collaborative environment where your contributions directly shape the team's scientific output.
What You'll Do
  • Maintain, seed, and harvest human iPSC and mammalian cell lines for downstream proteomics and imaging workflows.
  • Engineer and validate cell lines for proteomics assays (CRISPR endogenous tagging, lentiviral overexpression) .
  • Prepare samples for proximity labeling (e.g., TurboID) and immunoprecipitation plus crosslinking mass spec.
  • Prepare cell samples for cryoET and correlative light and electron microscopy (CLEM) experiments including transfections and fluorescence labeling.
  • Prepare vitrified samples using cryogenic freezing methods such as plunge freezing and high pressure freezing.
  • Perform cryo FIB milling on vitrified cellular samples using FIB-SEM instruments.
  • Assist with cryoET data collection, tomogram reconstruction, and visualization.
  • Work with team members to improve the throughput, reliability, and scalability of proteomics and imaging assays.
  • Maintain rigorous documentation of protocols, experimental conditions, results, sample tracking, and reagent inventory.
  • Contribute to publications and present findings internally and at scientific conferences.
What You'll Bring
Essentials
  • Bachelor's or Master's degree in Cell Biology, Biochemistry, Bioengineering, Molecular Biology, or a related discipline (or equivalent experience).
  • 2 years of experience in an RA I position, or 4 years of relevant, post-graduate research experience.
  • Experience maintaining mammalian and/or human pluripotent stem cell lines, with strong sterile technique and familiarity with culture best practices and quality control.
  • Experience with light or fluorescence microscopy.
  • Strong organizational skills and meticulous attention to detail across complex, multi-step experimental workflows.
  • A dynamic, adaptable, and self-motivated approach, with strong communication skills and the ability to work effectively in a collaborative team.
  • Enthusiasm for learning new techniques and contributing to cutting-edge, cross-disciplinary research.

Nice to have
  • Experience with immunoprecipitations, western blotting, and proteomics sample-preparation workflows.
  • Hands-on experience with proximity labeling approaches (TurboID, BioID, APEX).
  • Hands-on experience with CRISPR-based genome editing, including sgRNA and donor design.
  • Experience with cryogenic sample preparation, electron microscopy workflows, and/or operating or supporting FIB-SEM instrumentation.
  • Exposure to cryo-electron tomography and protein structure prediction.
  • Experience with coding (Python, R, etc.) for analysis of omics datasets, or with basic image/data processing and annotation workflows.
Compensation
The Redwood City, CA base pay range for a new hire in this role is $83,000.00 - $103,000.00. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process.
This position may be eligible to participate in our discretionary annual performance bonus program. Bonus eligibility and targets are determined in accordance with our total rewards philosophy and may vary by role.
Benefits for the Whole You
We're thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible.
  • Provides a generous employer match on employee 401(k) contributions to support planning for the future.
  • Paid time off to volunteer at an organization of your choice.
  • Funding for select family-forming benefits.
  • Relocation support for employees who need assistance moving

If you're interested in a role but your previous experience doesn't perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role.
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