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Entry Level Cryo Electron Microscopy Jobs (NOW HIRING)

Cogent Scientific

Expert Pharma Biochemist

Louisville, CO · On-site

$40K - $54K/yr

Preparing and optimizing samples for single-particle cryo-electron microscopy (cryo-EM): complex assembly, negative-stain/grid screening, vitrification, and iterative optimization. * Coordinating ...

Cogent Scientific

Expert Pharma Biochemist

Louisville, CO · On-site

$120 - $170/hr

Preparing and optimizing samples for single-particle cryo-electron microscopy (cryo-EM): complex assembly, negative-stain/grid screening, vitrification, and iterative optimization. * Coordinating ...

Cogent Scientific

Expert Pharma Biochemist

Louisville, CO · On-site

$40K - $54K/yr

Preparing and optimizing samples for single-particle cryo-electron microscopy (cryo-EM): complex assembly, negative-stain/grid screening, vitrification, and iterative optimization. * Coordinating ...

Cogent Scientific

Expert Pharma Biochemist

Louisville, CO · On-site

$115K - $125K/yr

Preparing and optimizing samples for single-particle cryo-electron microscopy (cryo-EM): complex assembly, negative-stain/grid screening, vitrification, and iterative optimization. * Coordinating ...

University of Colorado

Post-Doctoral Fellow

Aurora, CO · On-site

$49K - $67K/yr

By employing high-resolution cryo-electron microscopy (cryo-EM) and tomography (cryo-ET), we aim to capture the transient, high-order assemblies that trigger signaling in response to stress. In ...

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How much do entry level cryo electron microscopy jobs pay per hour?

As of Sep 6, 2026, the average hourly pay for entry level cryo electron microscopy in the United States is $19.18, according to ZipRecruiter salary data. Most workers in this role earn between $17.31 and $20.43 per hour, depending on experience, location, and employer.

What is an entry level cryo electron microscopy job?

Entry level cryo electron microscopy (cryo-EM) jobs are positions designed for individuals who are new to the field and want to gain hands-on experience with cryo-EM technology. These roles typically involve assisting with sample preparation, operating the electron microscope under supervision, maintaining equipment, and analyzing data under the guidance of senior scientists. Candidates usually have a background in biology, chemistry, physics, or a related field, and may be recent graduates or new to microscopy. Entry level roles provide valuable training and foundational skills for a career in structural biology or advanced microscopy research.

What key skills and qualifications are needed to thrive as an entry level cryo electron microscopy technician?

To thrive as an Entry Level Cryo Electron Microscopy Technician, a solid background in biology, chemistry, or physics and a bachelor’s degree in a relevant scientific field are essential. Familiarity with cryo-EM instrumentation, sample preparation protocols, and data analysis software such as RELION or CryoSPARC is typically required. Attention to detail, strong problem-solving abilities, and effective teamwork are standout soft skills in this role. These competencies ensure accurate data collection, high-quality imaging, and reliable scientific results in a collaborative research environment.

What are common challenges faced by entry-level professionals in cryo electron microscopy, and how can they be overcome?

Entry-level professionals in Cryo Electron Microscopy (Cryo-EM) often encounter challenges such as mastering complex instrumentation, learning sample preparation techniques, and interpreting large volumes of data. Gaining hands-on experience under the guidance of experienced colleagues and participating in specialized training workshops can help build confidence and technical proficiency. Regular communication with team members, including biologists, physicists, and data analysts, is also crucial for troubleshooting issues and ensuring successful project outcomes.

What is the difference between Entry Level Cryo Electron Microscopy vs Entry Level Transmission Electron Microscopy?

AspectEntry Level Cryo Electron MicroscopyEntry Level Transmission Electron Microscopy
CredentialsBachelor's degree in biology, chemistry, or related field; training in cryo techniquesBachelor's degree in materials science, physics, or related field; basic microscopy training
Work EnvironmentResearch labs, biotech, or pharmaceutical companies focusing on biological samplesMaterials labs, research institutions, or industrial settings analyzing materials or biological specimens
Industry UsagePrimarily in biological and biomedical researchUsed across materials science, biology, and nanotechnology sectors

Entry Level Cryo Electron Microscopy and Entry Level Transmission Electron Microscopy share foundational microscopy skills but differ in sample preparation, application focus, and industry usage. Cryo EM specializes in imaging frozen biological samples, while TEM is more versatile across biological and material sciences. Both roles require similar educational backgrounds and entry-level training, but their work environments and applications vary.

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Entry Level Cryo Electron Microscopy jobs near you
Infographic showing various Entry Level Cryo Electron Microscopy job openings in the United States as of August 2026, with employment types broken down into 92% Full Time, and 8% Part Time. Highlights an 100% In-person job distribution, with an average salary of $39,900 per year, or $19.2 per hour.

Postdoctoral Scholar, Department of Physiology & Biophysics

Case Western Reserve University

Cleveland, OH • On-site

$55K - $62K/yr

Full-time

Medical, Life

Posted 17 days ago

Case Western Reserve University rating

8.3

Company rating: 8.3 out of 10

Based on 24 frontline employees who took The Breakroom Quiz

127th of 631 rated colleges and universities

Job description

Description
The Zhu Lab in the Department of Physiology & Biophysics at Case Western Reserve University is seeking a qualified candidate to fill a postdoctoral scholar position. This is a one-year appointment with the possibility of renewal for additonal years, contingent upon satisfactory performance and continued funding. The candidate will investigate host defense mechansms and pathogen adaptation within host cells using cutting-edge cryo-electron tomography (cryo-ET) techniques in conjunction with cryo-correlative light and electron microscopy (cryo-CLEM) and cryo-focused ion beam/scanning electron microscopy (cryo-FIB/SEM).
This position focuses on elucidating the structural mechanisms of GBP1 (Guanylate Binding Protein 1), a critical interferon-induced immune protein that recognizes and destroys diverse intracellular bacterial pathogens. This postdoctoral fellow will visualize critical biological processes underlying host cell defense against microbial threats using state-of-the-art cryo-ET, and will contribute to developing novel in situ imaging methods for studying host-pathogen interactions at molecular resolution.
Other duties and responsibilities include:
  • Design and execute in vitro reconstitution experiments to investigate GBP1 targeting of pathogen surfaces, including protein purification, mutagenesis, and biochemical characterization.
  • Perform cryo-ET sample preparation and data collection, including plunge-freezing, cryo-FIB/SEM lamella millling, and tilt series acquisiton on the Titan Krios cryo-electron microscope.
  • Conduct cryo-CLEM to identify and target biological structures of interest, correlating flourescence signals with high-resolution ultrastructural data in both ex situ and in situ contexts.
  • Analyze cryo-ET datasets, including tomogram reconstruction, subtomogram averaging, and 3D structure determination, to elucidate GBP1 structural mechanisms during pathogen recognition and organelle interactions.
  • Perform mammaliam cell culture, genetic manipulation, and bacterial infection assays to generate cellular models for structural studies.

Qualifications
Ph.D. in Structural Biology, Biochemistry, Cell Biology, Microbiology, Immunology, or a related field. Experience with cryo-electron microscopy is preferred but not required; candidates with strong backgrounds in structural biology, biochemistry, or molecular/cell biology and a demonstrated interest in learning cryo-EM techniques will also be considered.
Candidates should have at least one peer reviewed publication. Ability to work independently and collaboratively in a multidisciplinary research environment.
In compliance with the City of Cleveland's Pay transparency Ordinance (effective October 27, 2025) the annual starting base salary range for this position is $55,000-$62,652. CWRU considers actors such as (but not limited to) the specific grant funding and the terms of research gant when extending an offer. Postdocs receive individual and family healthcare benefits, life insurance and employee assistance.
Application Instructions
Apply through nterfolio only
https://apply.interfolio.com/191863

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