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Formulation Lipid Nanoparticle Jobs (NOW HIRING)

Pharmaceutical Company

Scientist

San Diego, CA

Experience with lipid nanoparticle (LNP) formulation and characterization * Proficiency in DLS, Zeta potential, RiboGreen assays * Experience with purification tools such as ÄKTA or chromatography ...

Crispr Therapeutics

Scientist II, LNP

Boston, MA · On-site

$130K - $140K/yr

The ideal candidate will have experience in lipid nanoparticle (LNP) design, formulation and characterization, with proven experience in designing novel solutions for encapsulation of different ...

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Formulation Lipid Nanoparticle information

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How much do formulation lipid nanoparticle jobs pay per year?

As of Jun 15, 2026, the average yearly pay for formulation lipid nanoparticle in the United States is $119,503.00, according to ZipRecruiter salary data. Most workers in this role earn between $101,500.00 and $150,000.00 per year, depending on experience, location, and employer.

What are Formulation Lipid Nanoparticle specialists?

Formulation Lipid Nanoparticle specialists are scientists or engineers who design and develop lipid nanoparticles (LNPs) for the delivery of drugs, vaccines, or genetic material. They work on optimizing the composition, stability, and effectiveness of LNPs to ensure safe and efficient delivery of therapeutic agents into target cells. Their expertise is crucial in pharmaceutical research and manufacturing, especially for advanced therapies like mRNA vaccines and gene therapies.

What are some common challenges faced when developing lipid nanoparticle (LNP) formulations, and how can these be addressed in a lab environment?

A key challenge in developing lipid nanoparticle formulations is achieving consistent particle size and encapsulation efficiency, which are critical for drug delivery applications. Variability can arise due to differences in lipid ratios, mixing techniques, and process parameters. To address this, team members often work closely with analytical chemists to optimize protocols, standardize procedures, and troubleshoot issues such as aggregation or low yield. Regular collaboration and clear documentation help ensure reproducibility and successful scale-up from bench to production.

What is the difference between Formulation Lipid Nanoparticle vs Formulation Scientist?

AspectFormulation Lipid NanoparticleFormulation Scientist
Required CredentialsBachelor's or Master's in Pharmaceutical Sciences, Chemistry, or related fieldsBachelor's or Master's in Pharmaceutical Sciences, Chemistry, or related fields
Work EnvironmentLaboratories focused on nanoparticle formulation and drug deliveryResearch and development labs, manufacturing, or quality control
Industry UsageSpecialized in lipid-based drug delivery systemsBroader role in formulation development across various drug types

Formulation Lipid Nanoparticle specialists focus specifically on developing lipid-based nanocarriers for drug delivery, requiring expertise in nanoparticle technology. Formulation Scientists have a broader scope, working on various formulation types, including lipid nanoparticles, but with less specialization. Both roles often require similar educational backgrounds and work in related environments, but their focus areas differ significantly.

What are the key skills and qualifications needed to thrive as a Formulation Lipid Nanoparticle Scientist, and why are they important?

To excel as a Formulation Lipid Nanoparticle Scientist, you need a solid background in chemistry, pharmaceutical sciences, or related fields, often supported by an advanced degree and experience in nanoparticle formulation. Familiarity with analytical instruments (HPLC, DLS, LC-MS), nanoparticle synthesis equipment, and regulatory standards is crucial, along with knowledge of relevant laboratory software. Strong problem-solving, attention to detail, and effective communication skills help in managing complex experiments and collaborating across multidisciplinary teams. These competencies ensure the successful design, optimization, and scale-up of lipid nanoparticle formulations for drug delivery and therapeutic applications.
More about Formulation Lipid Nanoparticle jobs
What cities are hiring for Formulation Lipid Nanoparticle jobs? Cities with the most Formulation Lipid Nanoparticle job openings:
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What job categories do people searching Formulation Lipid Nanoparticle jobs look for? The top searched job categories for Formulation Lipid Nanoparticle jobs are:
Formulation Lipid Nanoparticle jobs near you
Infographic showing various Formulation Lipid Nanoparticle job openings in the United States as of June 2026, with employment types broken down into 100% Full Time. Highlights an 88% Physical, 2% Hybrid, and 10% Remote job distribution, with an average salary of $119,503 per year, or $57.5 per hour.
Senior Scientist, Formulation and Delivery Sciences

Senior Scientist, Formulation and Delivery Sciences

Ionis Pharmaceuticals

Carlsbad, CA • On-site, Remote

Full-time

Posted 6 days ago

Job description

Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We’re pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs.  With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals.

At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees. 

With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive. 

We’re building on our rich history, and we believe our greatest achievements are ahead of us. If you’re passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career!

Senior Scientist, Formulation and Delivery Sciences

We seek a Senior Scientist skilled in lipid nanoparticle formulation, targeted delivery, synthesis and characterization of conjugated targeting ligands, plasma protein corona analysis and control, RNA/LNP physicochemical characterization, and in vitro/in vivo performance assessment, with a focus on elucidating and overcoming mechanistic nanoparticle delivery hurdles. The successful candidate will work hands-on with receptor-targeted lipid nanoparticle screening, biochemical conjugation strategies, affinity and cellular uptake assays, and in vivo delivery studies. Reporting to the Director of Formulation and Delivery Sciences, this individual will help identify and validate receptor-ligand strategies, establish screening workflows, and optimize targeted lipid nanoparticle systems for extrahepatic delivery. The successful candidate is a highly collaborative, detail-oriented, and creative scientist who enjoys bench research, adheres to well-defined scientific direction and group goals, and is excited to join a strong multidisciplinary team at a leading nucleic acid therapeutics company.

RESPONSIBILITIES:
  • Design, produce, and characterize receptor-targeted lipid nanoparticle formulations for in vitro and preclinical in vivo studies.
  • Help identify and prioritize receptor-ligand pairs for targeted delivery applications based on biological rationale, feasibility, and experimental performance.
  • Develop and execute ligand conjugation workflows for lipid nanoparticles using biochemical and chemical conjugation approaches.
  • Establish and apply affinity, cellular uptake, and functional screening assays to evaluate targeted lipid nanoparticle constructs across ligand formats, densities, and formulations.
  • Generate and interpret data linking receptor binding, ligand density, cellular uptake, and in vivo delivery performance.
  • Partner with scientists across formulation, chemistry, biology, and analytical functions to refine targeted lipid nanoparticle design and advance company objectives.
  • When needed, assist other team projects with LNP production, in vivo testing, and downstream tissue collection and analysis.
  • Support routine in vivo studies and downstream tissue analysis, including coordination of sample collection and evaluation of distribution and activity readouts.
  • Thoroughly document results in notebooks and written reports, and present findings to cross-functional teams and at research meetings.
  • Contribute to publications, patent applications, and the continued development of Ionis targeted delivery capabilities.
QUALIFICATIONS:
  • PhD in Biochemistry strongly preferred; Chemistry, Chemical Engineering, Biophysics, Biomedical Engineering, Bioengineering, Pharmaceutics, or a related field will also be considered.
  • Minimum of 2 years of relevant industry experience following completion of a PhD or postdoctoral training.
  • Demonstrated experience with lipid nanoparticles, RNA therapeutics, receptor-targeted delivery, ligand conjugation, or related nanoparticle systems.
  • Excellent bench laboratory skills with a strong interest in hands-on experimental work and day-to-day laboratory execution.
  • High attention to detail, strong experimental rigor, and consistent documentation habits.
  • Self-motivated, able to stay on track with assigned goals and scientific direction, values collaboration, and thrives as part of a close-knit, high-performing team.
  • Creative and thoughtful problem solver who is open to adopting AI-enabled tools to improve research efficiency.
  • Hands-on experience with biochemical, biophysical, and analytical methods used to characterize ligands, lipid nanoparticles, and targeted delivery performance.
  • Experience with cell-based uptake or activity assays and supporting in vivo studies for targeted delivery platforms is highly desirable.
  • Proven skills in experimental design, data interpretation, formal oral and written communication, and cross-functional collaboration.

Please visit our website, http://www.ionis.com for more information about Ionis and to apply for this position; reference requisition # IONIS004054

Ionis offers an excellent benefits package! Follow this link for more details: Ionis Benefits

Full Benefits Link: https://ionis.com/careers#:~:text=Highly%20competitive%20benefits

The pay scale for this position is $113,156 - $149,750.00

NO PHONE CALLS PLEASE. PRINCIPALS ONLY.

Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.

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