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Formulation Lipid Nanoparticle Jobs (NOW HIRING)

Pivotal

Analytical Scientist, Ph.D.

San Diego, CA · On-site

$110 - $140/hr

... lipid nanoparticle (LNP) gene editing platform. This role requires deep expertise in LC/MS and ... Support formulation development, process development, and stability studies by providing timely ...

Pivotal

Analytical Scientist, Ph.D.

San Diego, CA · On-site

... lipid nanoparticle (LNP) gene editing platform. This role requires deep expertise in LC/MS and ... Support formulation development, process development, and stability studies by providing timely ...

APN Software Services Inc

Scientist I

San Diego, CA · On-site

Resume must haves: - LNP (Lipid Nanoparticle) formulation. - industry/company experience, not accepting purely academic experience. Position Summary We are seeking a motivated and detail-oriented ...

GenScript/ProBio

Project Manager - LNP

Redmond, WA

$70K - $85K/yr

Strong technical foundation in RNA biology and lipid nanoparticle (LNP) formulation, with hands-on laboratory or process development experience. * Prior project management experience preferred ...

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Formulation Lipid Nanoparticle information

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$55.5K

$119.5K

$174K

How much do formulation lipid nanoparticle jobs pay per year?

As of Aug 9, 2026, the average yearly pay for formulation lipid nanoparticle in the United States is $119,503.00, according to ZipRecruiter salary data. Most workers in this role earn between $101,500.00 and $150,000.00 per year, depending on experience, location, and employer.

What is a formulation lipid nanoparticle specialist?

Formulation Lipid Nanoparticle specialists are scientists or engineers who design and develop lipid nanoparticles (LNPs) for the delivery of drugs, vaccines, or genetic material. They work on optimizing the composition, stability, and effectiveness of LNPs to ensure safe and efficient delivery of therapeutic agents into target cells. Their expertise is crucial in pharmaceutical research and manufacturing, especially for advanced therapies like mRNA vaccines and gene therapies.

What are some common challenges faced when developing lipid nanoparticle (LNP) formulations, and how can these be addressed in a lab environment?

A key challenge in developing lipid nanoparticle formulations is achieving consistent particle size and encapsulation efficiency, which are critical for drug delivery applications. Variability can arise due to differences in lipid ratios, mixing techniques, and process parameters. To address this, team members often work closely with analytical chemists to optimize protocols, standardize procedures, and troubleshoot issues such as aggregation or low yield. Regular collaboration and clear documentation help ensure reproducibility and successful scale-up from bench to production.

What is the difference between Formulation Lipid Nanoparticle vs Formulation Scientist?

AspectFormulation Lipid NanoparticleFormulation Scientist
Required CredentialsBachelor's or Master's in Pharmaceutical Sciences, Chemistry, or related fieldsBachelor's or Master's in Pharmaceutical Sciences, Chemistry, or related fields
Work EnvironmentLaboratories focused on nanoparticle formulation and drug deliveryResearch and development labs, manufacturing, or quality control
Industry UsageSpecialized in lipid-based drug delivery systemsBroader role in formulation development across various drug types

Formulation Lipid Nanoparticle specialists focus specifically on developing lipid-based nanocarriers for drug delivery, requiring expertise in nanoparticle technology. Formulation Scientists have a broader scope, working on various formulation types, including lipid nanoparticles, but with less specialization. Both roles often require similar educational backgrounds and work in related environments, but their focus areas differ significantly.

What are the key skills and qualifications needed to thrive as a formulation lipid nanoparticle scientist, and why are they important?

To excel as a Formulation Lipid Nanoparticle Scientist, you need a solid background in chemistry, pharmaceutical sciences, or related fields, often supported by an advanced degree and experience in nanoparticle formulation. Familiarity with analytical instruments (HPLC, DLS, LC-MS), nanoparticle synthesis equipment, and regulatory standards is crucial, along with knowledge of relevant laboratory software. Strong problem-solving, attention to detail, and effective communication skills help in managing complex experiments and collaborating across multidisciplinary teams. These competencies ensure the successful design, optimization, and scale-up of lipid nanoparticle formulations for drug delivery and therapeutic applications.
More about Formulation Lipid Nanoparticle jobs
What cities are hiring for Formulation Lipid Nanoparticle jobs? Cities with the most Formulation Lipid Nanoparticle job openings:
What states have the most Formulation Lipid Nanoparticle jobs? States with the most job openings for Formulation Lipid Nanoparticle jobs include:
What job categories do people searching Formulation Lipid Nanoparticle jobs look for? The top searched job categories for Formulation Lipid Nanoparticle jobs are:
Formulation Lipid Nanoparticle jobs near you
Infographic showing various Formulation Lipid Nanoparticle job openings in the United States as of August 2026, with employment types broken down into 1% As Needed, 82% Full Time, 11% Part Time, 1% Temporary, 3% Contract, and 2% Nights. Highlights an 89% Physical, 2% Hybrid, and 9% Remote job distribution, with an average salary of $119,503 per year, or $57.5 per hour.

Analytical Scientist, Ph.D.

Pivotal Life Sciences

San Diego, CA • On-site

$110K - $140K/yr

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Re-posted 2 days ago

Job description

Analytical Scientist, Ph.D.
Location: San Diego, CA
Job Type: Full-Time, Onsite
About Us
We are an innovative, stealth-mode biotech focused on developing best-in-class delivery for in vivo gene editing.
Job Summary
We are seeking a highly skilled Analytical Scientist to join our team in a hands-on, lab-based role. The successful candidate will be responsible for developing, validating, and executing analytical methods for the characterization of proteins, RNA, and lipids, central to our lipid nanoparticle (LNP) gene editing platform. This role requires deep expertise in LC/MS and complementary analytical techniques, with the ability to independently design experiments, troubleshoot complex analytical challenges, and deliver high-quality data to support research, process development, and regulatory submissions. The Analytical Scientist will serve as a subject matter expert across the organization on bioanalytical methodologies. Title and salary will be commensurate with experience.
Responsibilities
  • Design, develop, optimize, and validate analytical methods for the characterization of proteins (e.g., Cas9, antibody constructs), mRNA, gRNA, and lipid components using LC/MS (intact mass, peptide mapping, oligonucleotide analysis, lipidomics).
  • Perform routine and non-routine hands-on analyses in the laboratory; operate, maintain, and troubleshoot LC/MS instrumentation (e.g., Q-TOF, Orbitrap, triple quadrupole) and associated sample preparation workflows.
  • Develop and execute orthogonal analytical methods including but not limited to HPLC/UPLC (RP, SEC, IEX, HILIC), capillary electrophoresis, UV/Vis spectrophotometry, and fluorescence-based assays.
  • Characterize LNP drug product attributes including lipid composition and ratios, encapsulation efficiency, RNA integrity, protein identity and purity, and post-translational or chemical modifications.
  • Support formulation development, process development, and stability studies by providing timely, high-quality analytical data and interpretation.
  • Author and review analytical methods, protocols, technical reports, and SOPs to support research activities and future regulatory filings.
  • Analyze and interpret complex mass spectrometry datasets; present findings to cross-functional teams and contribute to program-level decision-making.
  • Evaluate and implement new analytical technologies, software tools, and workflows to improve throughput, sensitivity, and data quality.
  • Collaborate closely with formulation scientists, biologists, process development, and CMC teams to ensure analytical needs are met across programs.
  • Maintain laboratory equipment, consumable inventories, and ensure compliance with safety and data integrity standards.

Qualifications
  • Ph.D. in Analytical Chemistry, Biochemistry, Chemistry, Pharmaceutical Sciences, or a related field.
  • 3+ years of industry or postdoctoral experience in bioanalytical method development and characterization of biopharmaceuticals, nucleic acids, or lipid-based drug products.
  • Extensive hands-on experience with LC/MS platforms (Q-TOF, Orbitrap, or triple quadrupole) for protein, oligonucleotide, and/or lipid analysis.
  • Proficiency in chromatographic techniques (RP-HPLC, SEC, IEX, HILIC) and associated data analysis software (e.g., MassLynx, Xcalibur, Empower, BioPharma Finder, UNIFI).
  • Strong understanding of protein characterization (intact mass, peptide mapping, glycosylation, disulfide mapping) and/or nucleic acid analysis (RNA integrity, modification mapping, sequence confirmation).
  • Demonstrated ability to independently design experiments, interpret complex datasets, and communicate results clearly in written and oral formats.
  • Strong problem-solving skills and ability to manage multiple projects in a fast-paced environment.

Preferred Qualifications
  • Experience with lipid nanoparticle characterization and/or lipidomics by LC/MS.
  • Familiarity with mRNA and guide RNA analytical characterization (e.g., capillary electrophoresis, IP-RP-HPLC, LC/MS-based modification analysis).
  • Experience supporting GMP or GLP analytical activities, method validation per ICH guidelines (Q2/Q14), or contributing to regulatory submissions.
  • Knowledge of gene therapy or gene editing product development and associated analytical expectations.
  • Experience with mass spectrometry-based quantitative assays (e.g., MRM/SRM for lipid or protein quantitation).

Benefits
  • Competitive salary, equity, and comprehensive benefits package.
  • Opportunities for professional growth and leadership development.
  • Fast-paced, collaborative, and innovative work environment.
  • We offer an exceptional benefits package to include Medical, Dental, Vision, Life, Disability, a 401k Match of 4%, Paid Time Off and Equity.

How to Apply
Interested candidates should submit their resume and a cover letter detailing relevant experience. To be considered for the role, applicants must be:
  • Eligible to work in the United States for any employer without current or future sponsorship.
  • Able to work onsite in our San Diego, CA lab.
  • Direct candidates only and not from a third party, i.e., staffing agency.

Equal Opportunity Employer
We are an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. All employment decisions are based on business needs, job requirements, and individual qualifications, without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran, or disability status.
Salary Range
$110,000 - $140,000

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