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Downstream Processing Jobs in California (NOW HIRING)

Abzena Inc.

Manufacturing Lead - Shift B

Carlsbad, CA · On-site

This role provides day-to-day directional leadership, coordination, and training for manufacturing personnel involved in upstream and downstream processing activities, including cell culture ...

Valspec

CQV Consultant

Oceanside, CA · On-site

Downstream Processing * CIP (Clean-in-Place) Systems * PSE (Process Support Equipment) * Clean Utilities Key Responsibilities * Execute CQV lifecycle activities including commissioning, IQ/OQ, and ...

BioMADE

Shift Supervisor

Hayward, CA · On-site

$110K - $130K/yr

... downstream processes at a scale which supports future commercial scale design. The Shift Supervisor will champion a Zero‑Harm safety culture and promote full engagement in all safety programs. With ...

Intuitive Surgical

$148K - $196K/yr

As a Downstream Product Manager, you will drive the development, launch, and sustaining of cutting ... Ensure execution of a smooth product rollout process, primarily in the United States but also ...

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All JobsDownstream Processing JobsDownstream Processing Jobs in California

Downstream Processing information

See California salary details

$13

$24

$35

How much do downstream processing jobs pay per hour?

As of Jul 13, 2026, the average hourly pay for downstream processing in California is $24.35, according to ZipRecruiter salary data. Most workers in this role earn between $19.47 and $27.74 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive in the Downstream Processing position, and why are they important?

To thrive in Downstream Processing, you typically need a background in biochemistry, chemical engineering, or a related field, along with experience in purification and separation techniques. Familiarity with technical tools such as chromatography systems, filtration units, and process control software, as well as cGMP certification, is often required. Strong attention to detail, problem-solving skills, and effective teamwork are valuable soft skills for this role. These competencies ensure efficient production, product quality, and compliance in highly regulated biopharmaceutical environments.

What is the best job in science stream?

The best job in the science stream depends on individual interests and skills, but roles such as research scientist, biomedical engineer, or data analyst are highly regarded. These positions often require relevant degrees, technical skills, and sometimes certifications, and they offer opportunities in research, healthcare, and technology sectors.

What are the typical daily responsibilities of someone working in Downstream Processing?

In Downstream Processing, your daily activities often include operating and optimizing purification systems, conducting in-process testing, and meticulously documenting process parameters and results. You’ll collaborate closely with upstream teams, quality control labs, and engineering staff to troubleshoot and improve workflows. Managing equipment maintenance, adhering to safety and compliance standards, and actively participating in process development projects are also key facets of the job. This hands-on role is essential for ensuring the purity and consistency of biopharmaceutical products.

What is a Downstream Processing job?

A Downstream Processing (DSP) job involves purifying and recovering biomolecules, such as proteins or vaccines, after fermentation or cell culture. Professionals in this role use techniques like filtration, chromatography, and centrifugation to ensure product purity and quality. They work in industries like pharmaceuticals, biotechnology, and bioprocessing. Key responsibilities include optimizing purification processes, troubleshooting equipment, and ensuring compliance with regulatory standards.

What is a downstream technician?

A downstream technician is responsible for the purification and formulation of biopharmaceutical products after the initial production phase. They operate equipment such as chromatography systems and filtration units, following strict safety and quality protocols, often requiring knowledge of Good Manufacturing Practices (GMP).

What are the life science jobs?

Downstream processing jobs in the life sciences involve the purification and recovery of biological products such as proteins, vaccines, and antibodies. These roles typically require knowledge of bioprocessing techniques, laboratory skills, and familiarity with equipment like chromatography systems. Positions may include process technicians, bioprocess engineers, and quality control specialists working in manufacturing or research settings.

What is the role of a bioprocess engineer?

A bioprocess engineer designs, develops, and optimizes processes for producing biological products such as vaccines, therapeutics, and enzymes. They work with bioreactors, chromatography, and other downstream processing techniques to ensure efficient and scalable manufacturing, often requiring knowledge of biochemistry, engineering principles, and regulatory standards.
What are the most commonly searched types of Downstream Processing jobs in California? The most popular types of Downstream Processing jobs in California are:
What are popular job titles related to Downstream Processing jobs in California? For Downstream Processing jobs in California, the most frequently searched job titles are:
What job categories do people searching Downstream Processing jobs in California look for? The top searched job categories for Downstream Processing jobs in California are:
Downstream Processing jobs near you
Infographic showing various Downstream Processing job openings in California as of July 2026, with employment types broken down into 83% Full Time, and 17% Part Time. Highlights an 100% In-person job distribution, with an average salary of $50,647 per year, or $24.3 per hour.
Scientist I - Lipid Nanoparticles

Scientist I - Lipid Nanoparticles

Dawar Consulting, Inc.

San Diego, CA • On-site

$46 - $49/hr

Full-time

Medical, Dental, Vision, Retirement

Posted 7 days ago

Job description

Our client, a world leader in biotechnology and gene therapy, is looking for a “Scientist I – Lipid Nanoparticles” based in San Diego, CA.


Job Duration: Long Term Contract (Possibility Of Extension)

Pay Rate : $49/hr on W2


Company Benefits: Medical, Dental, Vision, Paid Sick leave, 401K


Seeking a hands-on Scientist I to support the development of lipid nanoparticle (LNP) formulations for nucleic acid delivery. This role involves LNP synthesis, formulation optimization, characterization, data analysis, and collaboration with cross-functional teams to advance non-viral drug delivery platforms.


Key Responsibilities:

  • Develop, optimize, and characterize LNP formulations encapsulating mRNA, siRNA, or DNA for in vitro and in vivo studies.
  • Design and execute formulation optimization studies using Design of Experiments (DoE).
  • Perform LNP characterization using DLS, Zeta Potential, and Ribogreen assays.
  • Support formulation development activities, including scale-up, stability studies, cryoprotection, and downstream processing.
  • Analyze experimental data, maintain accurate laboratory documentation, and present findings to project teams.
  • Collaborate with cross-functional teams and support routine laboratory operations.


Qualifications:

  • Bachelor's degree in Chemistry, Biochemistry, Chemical Engineering, or a related field with 2+ years of biopharma experience, or a Master's degree with 1+ year of industry experience.
  • Hands-on experience with LNP formulation and nucleic acid encapsulation (mRNA, siRNA, or DNA).
  • Experience with Dynamic Light Scattering (DLS), Zeta Potential, and Ribogreen assays.
  • Preferred experience with Tangential Flow Filtration (TFF), dialysis, bioconjugation, and statistical analysis tools (JMP, Prism).




If interested, please send us your updated resume at

hr@dawarconsulting.com/akansha@dawarconsulting.com