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Downstream Processing Jobs in California (NOW HIRING)

BioMADE

Process Engineer

Hayward, CA · On-site

$120K - $150K/yr

... downstream processing unit operations, with particular emphasis on downstream separations and purification systems. The Process Engineer will actively promote and exemplify a "zero harm" safety ...

Oath

Fermentation Scientist

Vacaville, CA · On-site

$100K - $130K/yr

Develop and improve downstream processing (DSP) approaches for microbial biomass and product recovery. * Troubleshoot fermentation and DSP performance and identify key drivers of process variability.

Oath

Fermentation Scientist

Vacaville, CA · Hybrid

$100K - $130K/yr

Develop and improve downstream processing (DSP) approaches for microbial biomass and product recovery. * Troubleshoot fermentation and DSP performance and identify key drivers of process variability.

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How much do downstream processing jobs pay per hour?

As of Sep 13, 2026, the average hourly pay for downstream processing in California is $24.35, according to ZipRecruiter salary data. Most workers in this role earn between $19.47 and $27.74 per hour, depending on experience, location, and employer.

What is downstream processing?

A Downstream Processing (DSP) job involves purifying and recovering biomolecules, such as proteins or vaccines, after fermentation or cell culture. Professionals in this role use techniques like filtration, chromatography, and centrifugation to ensure product purity and quality. They work in industries like pharmaceuticals, biotechnology, and bioprocessing. Key responsibilities include optimizing purification processes, troubleshooting equipment, and ensuring compliance with regulatory standards.

What are the typical daily responsibilities of someone working in downstream processing?

In Downstream Processing, your daily activities often include operating and optimizing purification systems, conducting in-process testing, and meticulously documenting process parameters and results. You’ll collaborate closely with upstream teams, quality control labs, and engineering staff to troubleshoot and improve workflows. Managing equipment maintenance, adhering to safety and compliance standards, and actively participating in process development projects are also key facets of the job. This hands-on role is essential for ensuring the purity and consistency of biopharmaceutical products.

What are the key skills and qualifications needed to thrive in downstream processing, and why are they important?

To thrive in Downstream Processing, you typically need a background in biochemistry, chemical engineering, or a related field, along with experience in purification and separation techniques. Familiarity with technical tools such as chromatography systems, filtration units, and process control software, as well as cGMP certification, is often required. Strong attention to detail, problem-solving skills, and effective teamwork are valuable soft skills for this role. These competencies ensure efficient production, product quality, and compliance in highly regulated biopharmaceutical environments.

What does downstream processing involve?

Downstream processing involves the purification and recovery of products such as proteins, enzymes, or pharmaceuticals from bioreactors. It includes steps like filtration, chromatography, and concentration to ensure product quality and safety, often requiring knowledge of bioprocessing techniques and quality control standards.

What are the most commonly searched types of Downstream Processing jobs in California?

The most popular types of Downstream Processing jobs in California are:

What are popular job titles related to Downstream Processing jobs in California?

For Downstream Processing jobs in California, the most frequently searched job titles are:

What job categories do people searching Downstream Processing jobs in California look for?

The top searched job categories for Downstream Processing jobs in California are:

Downstream Processing jobs near you
Infographic showing various Downstream Processing job openings in California as of September 2026, with employment types broken down into 1% As Needed, 78% Full Time, 17% Part Time, 1% Temporary, 2% Contract, and 1% Nights. Highlights an 91% Physical, 2% Hybrid, and 7% Remote job distribution, with an average salary of $50,647 per year, or $24.3 per hour.

Associate Director, Downstream Process Development

Redwood City, CA • On-site

Allakos
Biotechnology Research and Development • 51 - 200 employees
Learn more about Allakosexternal

Full-time

Re-posted 16 days ago

Job description

Associate Director, Downstream Process Development
Allakos Inc. is a clinical-stage company developing therapeutic antibodies for inhibitory receptors on the surface of immune effector cells involved in allergic, inflammatory and proliferative diseases.
Allakos is committed to developing innovative therapies that transform patients’ lives. We are looking for bright and talented individuals to join our team and share in our passion and commitment to improving the lives of patients.
Position Summary:
As a member of the Allakos team you will have the opportunity to be a key member of the Biologics DS development and Tech Transfer team and responsible for activities related to Downstream Process Development of our late-stage clinical biologic (Mab) molecule AK002 and other early-stage programs. This position will be responsible for the Process Development, Tech Transfer, and oversite of Engineering/Clinical batches at contract manufacturing site/s. Additionally, there will be a strong focus on BLA-enabling activities including process characterization, PPQ Batches and BLA authoring and review.
Your Role:
  • Provide technical leadership to the Downstream Process Development group and technology transfer of AK002 process to CMO sites.
  • Accountable for activities pertaining to the downstream process development lab. Supervise planning and execution of experiments. Analyze results and communicate them effectively to management.
  • Coordinate with Upstream Development, Analytical, and Facilities departments to successfully complete the DSP activities.
  • Provide input for the strategy and experimental plan for downstream process characterization studies. Generate protocols, supervise execution, use statistical tools to analyze results, and review reports for studies.
  • Assist in the planning of downstream process development experiments for new molecules and supervise execution of the same.
  • Supervise the Engineering and Clinical batches at CMOs, review and approve Deviations and CAPA documents for these batches.
  • Plan and supervise PPQ batches at CMOs. Review and approve protocols and reports for PPQ batches.
  • Author BLA submission documents.
  • Travel domestically and internationally up to 10% of the time.
What We Value:
  • At least 12 years of relevant experience (10+ with M.S., 8+ for Ph.D.) successfully working in the biopharmaceutical industry with proven track record of leadership and success.
  • At least 5 years managing cross functional projects and leading teams.
  • Extensive experience in Downstream Process Development and process characterization of biologics, such as Mabs and fusion proteins.
  • Strong background in statistical design of experiments (DoE) and associated analysis
  • Experience in technology transfer and facility fit assessments.
  • Should have worked with late and commercial stage biologics, with experience in process development, process characterization, PPQ batches, and other BLA enabling studies and CPV programs.
  • Experience working with Contract Manufacturers is preferred.
  • Experienced in BLA submission write ups.
  • Experienced in people and stakeholder management, conflict resolution, and building consensus.
  • Good understanding of cGMP-regulations including relevant US/EU regulatory and quality requirements, practices, and standards.
  • Exceptional interpersonal skills to establish positive relationships with internal stakeholders, CROs/CMOs, and multi-functional/multi-cultural teams.
  • Ability to travel at least 10% of the time.
The Allakos Values are: Selflessness, Drive, Clarity, Thoughtfulness, Fun, and Leadership.
Allakos is an equal opportunity employer. Allakos will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, gender identity or re-assignment, marital or civil partnership status, protected veteran status (if applicable) or any other characteristic protected by law.
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About Allakos

Sourced by ZipRecruiter

Industry

Biotechnology research and development

Company size

51 - 200 Employees

Headquarters location

Redwood City, CA, US

Year founded

2012

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