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Downstream Processing Jobs in California (NOW HIRING)

Valspec

Validation Engineer (CQV)

Oceanside, CA

This role will focus on downstream process systems and requires strong hands-on field execution, system troubleshooting, and automation verification experience in a GMP-regulated environment. Key ...

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$13

$24

$35

How much do downstream processing jobs pay per hour?

As of Jul 13, 2026, the average hourly pay for downstream processing in California is $24.35, according to ZipRecruiter salary data. Most workers in this role earn between $19.47 and $27.74 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive in the Downstream Processing position, and why are they important?

To thrive in Downstream Processing, you typically need a background in biochemistry, chemical engineering, or a related field, along with experience in purification and separation techniques. Familiarity with technical tools such as chromatography systems, filtration units, and process control software, as well as cGMP certification, is often required. Strong attention to detail, problem-solving skills, and effective teamwork are valuable soft skills for this role. These competencies ensure efficient production, product quality, and compliance in highly regulated biopharmaceutical environments.

What is the best job in science stream?

The best job in the science stream depends on individual interests and skills, but roles such as research scientist, biomedical engineer, or data analyst are highly regarded. These positions often require relevant degrees, technical skills, and sometimes certifications, and they offer opportunities in research, healthcare, and technology sectors.

What are the typical daily responsibilities of someone working in Downstream Processing?

In Downstream Processing, your daily activities often include operating and optimizing purification systems, conducting in-process testing, and meticulously documenting process parameters and results. You’ll collaborate closely with upstream teams, quality control labs, and engineering staff to troubleshoot and improve workflows. Managing equipment maintenance, adhering to safety and compliance standards, and actively participating in process development projects are also key facets of the job. This hands-on role is essential for ensuring the purity and consistency of biopharmaceutical products.

What is a Downstream Processing job?

A Downstream Processing (DSP) job involves purifying and recovering biomolecules, such as proteins or vaccines, after fermentation or cell culture. Professionals in this role use techniques like filtration, chromatography, and centrifugation to ensure product purity and quality. They work in industries like pharmaceuticals, biotechnology, and bioprocessing. Key responsibilities include optimizing purification processes, troubleshooting equipment, and ensuring compliance with regulatory standards.

What is a downstream technician?

A downstream technician is responsible for the purification and formulation of biopharmaceutical products after the initial production phase. They operate equipment such as chromatography systems and filtration units, following strict safety and quality protocols, often requiring knowledge of Good Manufacturing Practices (GMP).

What are the life science jobs?

Downstream processing jobs in the life sciences involve the purification and recovery of biological products such as proteins, vaccines, and antibodies. These roles typically require knowledge of bioprocessing techniques, laboratory skills, and familiarity with equipment like chromatography systems. Positions may include process technicians, bioprocess engineers, and quality control specialists working in manufacturing or research settings.

What is the role of a bioprocess engineer?

A bioprocess engineer designs, develops, and optimizes processes for producing biological products such as vaccines, therapeutics, and enzymes. They work with bioreactors, chromatography, and other downstream processing techniques to ensure efficient and scalable manufacturing, often requiring knowledge of biochemistry, engineering principles, and regulatory standards.
What are the most commonly searched types of Downstream Processing jobs in California? The most popular types of Downstream Processing jobs in California are:
What are popular job titles related to Downstream Processing jobs in California? For Downstream Processing jobs in California, the most frequently searched job titles are:
What job categories do people searching Downstream Processing jobs in California look for? The top searched job categories for Downstream Processing jobs in California are:
Downstream Processing jobs near you
Infographic showing various Downstream Processing job openings in California as of July 2026, with employment types broken down into 83% Full Time, and 17% Part Time. Highlights an 100% In-person job distribution, with an average salary of $50,647 per year, or $24.3 per hour.
Supervisor, Manufacturing Downstream

Supervisor, Manufacturing Downstream

Avid Bioservices

Tustin, CA

$75K - $95K/yr

Full-time

Medical, Dental, Vision, Retirement, PTO

Re-posted 19 days ago

Job description

Looking to join a passionate team dedicated to developing and manufacturing life-saving biopharmaceuticals? Avid Bioservices is a leading clinical and commercial biologics CDMO focused on creating innovative solutions to meet the needs of our clients and improve patient outcomes.
Your Role:
The Supervisor, Manufacturing Downstream is responsible for the supervision of Downstream manufacturing staff and operations as well as regularly performing hands-on operational activities. This includes ensuring that production is maintained in full cGMP compliance through on the floor observation, direction, and participation.
  • Schedule, plan and coordinate production activities.
  • Perform purification operations (column chromatography, nano-filtration, tangential flow filtration, aseptic bulk fills, etc.) on the production floor, as required.
  • cGMP documentation.
  • Revise initiate and review Batch Production Records (BPRs), Standard Operating Procedures (SOPs), forms and Batch History Records (BHRs).
  • Identify, escalate, and write deviation reports (IRs/DRs/CAPAs). Follow through on corrective and preventative actions to ensure cGMP compliance.
  • Manage the development of SOPs to ensure all manufacturing operations comply with internal and external regulatory agencies.
  • Coordinate manufacturing, validation, and maintenance activities with supporting departments.
  • Oversee the setup of new manufacturing processes and critical equipment.
  • Identify the technical, procedural and equipment issues that hinder production and compliance.
  • Communicate with team members, supervisor and members of other departments, as appropriate, to assure prompt resolution of problems.
  • Assist in the transfer of technology from Process Development to GMP Manufacturing.
  • Assist with technical and compliance investigations, inspections and audits.
  • Report all unsafe activities to department manager, EHS and/or Human Resources.
  • Participate in proactive team efforts to achieve departmental and company goals.
  • Manage direct reports and escalate issues to manager as needed.
  • Perform other duties as assigned
Minimum Qualifications:
  • Bachelor's degree in biology, Biotechnology, Chemical Engineering or related field plus 3 - 5 years' cGMP purification experience or equivalent combination of experience and education.
  • A minimum of 3 years of supervisory experience specifically in downstream processing is required. The ideal candidate will be a self-driven leader with a proven track record of building strong and efficient floor operations.

Preferred Qualifications:

  • Bachelor's degree in life sciences or related field.
Position Type/Expected Hours of Work:
This role is a full-time position with a Sunday through Wednesday schedule, working 10 hours each day (4 x 10 hours), with operating hours from 7:00am to 6:00pm, unless otherwise stated by Supervisor. The employee must also, if instructed, have the ability to work overtime, weekends and/or holidays when necessary.
Compensation:
We offer competitive compensation packages for this role, including a base salary, performance-based bonuses, and comprehensive benefits such as health, dental, and vision insurance, 401(k) matching, and paid time off.
The compensation range for this role is $75,000 - $95,000 annually depending on experience and qualifications. Additionally, we offer opportunities for career growth and development as well as a supportive and inclusive work environment.
Who you are:
  • You have a "bring it on!" team player approach and an unshakable positive attitude, always ready to tackle anything that comes your way.
  • Your written and verbal skills are out of this world, and you communicate with clarity and confidence.
  • You have exceptional multitasking skills and an unparalleled attention to detail that ensure the smooth running of everything.
  • You are a master at building relationships, capable of establishing connections with anyone, be it team members, clients, vendors, or suppliers.
Physical Demands & Work Environment:
In this dynamic role, expect a blend of regular activities like sitting, standing, and walking, with occasional physically engaging tasks such as lifting objects up to 20 pounds. The work environment might expose you to electrical shocks, toxic chemicals, vibrations, or loud noise levels occasionally. However, reasonable accommodations are available to enable individuals with different abilities to perform effectively, ensuring a supportive and adaptable work setting. Your visual acuity, including close, distance, and color vision, will be essential in navigating through the diverse day-to-day demands of this position.
Employment Type: Full-Time

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