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Dna Encoded Libraries Jobs (NOW HIRING)

Overview DNA-encoded library (DEL) and SELEX (Systematic Evolution of Ligands by EXponential enrichment) technologies are rapidly expanding drug discovery platforms within the IVBU at WuXi AppTec.

Senior Scientist I

Cambridge, MA · On-site

$99.20K - $130.20K/yr

The scientist will work closely with medicinal chemistry and DNA encoded library groups to develop new synthesis and screening technologies on and off beads. The successful candidate will be a ...

Senior Scientist I

Cambridge, MA · Hybrid

$99.20K - $130.20K/yr

The scientist will work closely with medicinal chemistry and DNA encoded library groups to develop new synthesis and screening technologies on and off beads. The successful candidate will be a ...

Senior Scientist, Bio AI

Redwood City, CA · On-site

$205K - $235K/yr

... DNA in a stealth LNP. Once activated, they force the cancer cells to produce encoded proteins - T ... libraries of DNA or RNA sequences * Proficiency in routine bioinformatic analyses such as ...

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Dna Encoded Libraries information

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How much do dna encoded libraries jobs pay per hour?

As of May 31, 2026, the average hourly pay for dna encoded libraries in the United States is $65.38, according to ZipRecruiter salary data. Most workers in this role earn between $63.94 and $66.83 per hour, depending on experience, location, and employer.

What are the key skills and qualifications needed to thrive as a DNA Encoded Libraries (DEL) Scientist, and why are they important?

To thrive as a DNA Encoded Libraries (DEL) Scientist, you need a solid background in chemistry, molecular biology, and drug discovery, usually with an advanced degree (PhD or MSc) in a relevant field. Familiarity with DEL technology platforms, high-throughput screening systems, and data analysis software is typically required. Strong problem-solving skills, attention to detail, and effective cross-disciplinary communication help individuals excel in this role. These competencies are crucial for efficiently designing, executing, and interpreting DEL experiments that accelerate the identification of new therapeutic compounds.

What are some typical challenges faced by scientists working with DNA-encoded libraries (DELs), and how can they be addressed?

Scientists working with DNA-encoded libraries often encounter challenges such as maintaining the integrity of DNA tags during chemical synthesis, ensuring efficient library encoding, and accurately decoding hits after screening. Addressing these issues requires careful optimization of reaction conditions to prevent DNA degradation, thorough validation of encoding and decoding steps, and close collaboration with bioinformatics specialists to analyze sequencing data. Working in multidisciplinary teams and staying current with advances in DEL technology can also help scientists overcome technical hurdles and contribute to successful drug discovery campaigns.

What are DNA Encoded Libraries?

DNA Encoded Libraries (DELs) are collections of small molecules that are each attached to a unique DNA sequence acting as a molecular barcode. This technology allows researchers to rapidly screen millions to billions of compounds simultaneously to identify those that bind to a biological target, which is especially useful in early-stage drug discovery. The DNA tags make it possible to track and identify active compounds using DNA sequencing techniques, greatly increasing throughput and efficiency compared to traditional screening methods.

What is the difference between Dna Encoded Libraries vs Synthetic Chemistry Chemist?

AspectDna Encoded LibrariesSynthetic Chemistry Chemist
Required CredentialsTypically a background in molecular biology, biochemistry, or related fields; often with experience in library synthesis and screeningUsually a degree in chemistry or chemical engineering; expertise in organic synthesis and reaction mechanisms
Work EnvironmentLaboratory focused on high-throughput screening, drug discovery, and molecular biology techniquesLaboratories or industrial settings focused on chemical synthesis, process development, and compound optimization
Industry UsagePrimarily used in pharmaceutical and biotech industries for drug discoveryUsed across pharmaceuticals, materials science, and chemical manufacturing

In summary, Dna Encoded Libraries specialists focus on creating and screening vast collections of DNA-tagged molecules for drug discovery, requiring expertise in molecular biology. Synthetic Chemistry Chemists concentrate on designing and synthesizing chemical compounds through organic reactions, emphasizing chemical expertise. Both roles are essential in the pharmaceutical industry but differ in their techniques and focus areas.

More about Dna Encoded Libraries jobs
What cities are hiring for Dna Encoded Libraries jobs? Cities with the most Dna Encoded Libraries job openings:
What states have the most Dna Encoded Libraries jobs? States with the most job openings for Dna Encoded Libraries jobs include:
Infographic showing various Dna Encoded Libraries job openings in the United States as of May 2026, with employment types broken down into 100% Full Time. Highlights an 100% In-person job distribution, with an average salary of $135,999 per year, or $65.4 per hour.
Director / Senior Director, Small Molecule External Innovation

Director / Senior Director, Small Molecule External Innovation

Lilly

South San Francisco, CA • On-site

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Posted 21 days ago


Eli Lilly and Company rating

8.8

Company rating: 8.8 out of 10

Based on 62 frontline employees who took The Breakroom Quiz

11th of 70 rated pharmaceutical


Job description

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.

About the Team

Lilly Small Molecule Discovery (LSMD) exists to create molecules that make life better for people - using cutting-edge science to open new doors for diseases with limited treatment options.

Small Molecule External Innovation (SM E&I) identifies, evaluates, secures, and integrates transformative external technologies, capabilities, and assets that strengthen Lilly's small molecule discovery. The team works across three pillars: transformative assets accessed through license or acquisition, emerging platforms and technologies accessed through research collaborations, and capability built through integrated discovery partnerships. These pillars address real and pressing strategic needs: difficult targets, unconventional chemical space, and compressed competitive timelines.

What You'll Do

This is a high-impact, high-autonomy role at the intersection of science and strategy. You'll be SM E&I's primary connector to the external biotech, venture, and academic ecosystems - guiding opportunities from first contact through due diligence, governance, deal finalization, and internal adoption.

Sourcing & Evaluation

  • Source and evaluate external capabilities, technologies, and assets across all three pillars, drawing on your drug discovery expertise and understanding of LSMD's strategic needs.

  • Maintain a structured pipeline of external opportunities - including potential asset acquisitions, research collaborations, and discovery partnerships - with clear status tracking, strategic fit assessment, and next steps.

Relationship Building & Ecosystem Engagement

  • Build and sustain relationships across the biotech, venture capital, academic, and CRO ecosystems to surface opportunities aligned with LSMD's priorities.

  • Represent SM E&I at partnering events (JPM, BIO, BioEurope), venture showcases, and scientific conferences.

Due Diligence & Governance

  • Lead cross-functional scientific due diligence by coordinating input from LSMD experts across medicinal chemistry, computational chemistry, automation, pharmacology, biophysics, and AI/ML.

  • Author structured evaluation reports, investment theses, and governance presentations for senior leadership.

Competitive Intelligence & Strategy

  • Own and maintain a living competitive landscape across SM E&I's key technology domains - tracking partnership activity, asset licensing transactions, technology acquisitions, and emerging science that may shift LSMD's priorities.

  • Translate landscape intelligence into clear, actionable strategic recommendations for LSMD leadership.

Cross-Functional Collaboration

  • Partner closely with Therapeutic Area Search & Evaluate teams, Lilly Research Labs, Lilly's venture ecosystem (Catalyze360), and Corporate BD to ensure portfolio coherence and execution quality.

Basic Qualification

  • PhD (with 7+ years of experience), Master degree (with 10 + years of experience) in pharmaceutical or biotechnology R&D, with a foundation in drug discovery or translational science

  • 3+ years of experience in external innovation, search and evaluation, business development scouting, or a similar function involving systematic evaluation of external scientific opportunities

Additional Skills/Preference:

  • Broad scientific literacy across drug discovery fields - chemistry, biology, pharmacology, AI/ML, automation, and translational science - with the ability to coordinate and synthesize specialist input

  • Experience conducting or leading structured scientific due diligence for licensing, collaboration, or investment opportunities

  • Strong written communication skills, with experience preparing evaluation reports or governance materials for senior leadership

  • Familiarity with the external biotech and health-tech ecosystem, including experience engaging venture-backed and early-stage companies

  • Familiarity with at least two technology areas such as: macrocyclic drug design, targeted protein degradation, AI/ML driven drug discovery, automation, protein-protein interaction modulators, or DNA-encoded libraries

  • Exposure to deal structures (research collaborations, licensing, option agreements, asset acquisitions) sufficient to contribute meaningfully to strategic deal discussions

  • Strong business sense with demonstrated ability to persuade, and influence across internal and external partners

  • Strong interpersonal and communication skills, with a track record of building trust and influencing across functions and seniority levels

  • Ability to manage multiple concurrent evaluations in a dynamic environment

  • Collaborative personality well-suited to a small, high-autonomy team

Additional Information

  • This role supports work across Lilly's core therapeutic areas: Diabetes/Obesity/Cardiometabolic, Neuroscience, Immunology, Oncology, Genetic Medicines, and Advanced Modalities

  • Up to 40% travel (domestic and international)

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.


Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia Network, Black Employees at Lilly, Chinese Culture Network, Japanese International Leadership Network (JILN), Lilly India Network, Organization of Latinx at Lilly (OLA), PRIDE (LGBTQ+ Allies), Veterans Leadership Network (VLN), Women's Initiative for Leading at Lilly (WILL), enAble (for people with disabilities). Learn more about all of our groups.

Actual compensation will depend on a candidate's education, experience, skills, and geographic location. The anticipated wage for this position is

$148,500 - $217,800

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly's compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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About Eli Lilly

Sourced by ZipRecruiter

Eli Lilly, based in Indianapolis, IN, US, is one of the pioneers in the pharmaceutical industry with a rich history dating back to 1876. This global pharmaceutical company focuses on discovering, developing, manufacturing and selling pharmaceutical products in approximately 120 countries. The company's product categories include endocrinology, oncology, cardiovascular, neuroscience, and immunology. Having invested over $9 billion in research and development in the past decade, Eli Lilly is also committed to creating high-quality medicines that meet real needs. As a recipient of several awards and recognitions, Eli Lilly is known for its focus on life-saving research and drug development. Their mission is to make medicines that help people live longer, healthier, and more active lives.

Industry

Pharmaceutical product wholesalers

Company size

10,000+ Employees

Headquarters location

Indianapolis, IN, US

Year founded

1876