Design and synthesize DNA-encoded libraries, contribute to DEL-based lead discovery, and engage in cross-functional scientific discussions. * Contribute to multidisciplinary lead-finding project ...
Design and synthesize DNA-encoded libraries, contribute to DEL-based lead discovery, and engage in cross-functional scientific discussions. * Contribute to multidisciplinary lead-finding project ...
Staff Scientist - Medicinal Chemistry
Houston, TX · On-site
$72K - $75K/yr
Design and synthesize DNA-encoded libraries, contribute to DEL-based lead discovery, and engage in cross-functional scientific discussions. * Contribute to multidisciplinary lead-finding project ...
Staff Scientist - Medicinal Chemistry
Houston, TX · On-site
$72K - $75K/yr
Design and synthesize DNA-encoded libraries, contribute to DEL-based lead discovery, and engage in cross-functional scientific discussions. * Contribute to multidisciplinary lead-finding project ...
Dna Encoded Libraries information
What are the key skills and qualifications needed to thrive as a DNA Encoded Libraries (DEL) Scientist, and why are they important?
To thrive as a DNA Encoded Libraries (DEL) Scientist, you need a solid background in chemistry, molecular biology, and drug discovery, usually with an advanced degree (PhD or MSc) in a relevant field. Familiarity with DEL technology platforms, high-throughput screening systems, and data analysis software is typically required. Strong problem-solving skills, attention to detail, and effective cross-disciplinary communication help individuals excel in this role. These competencies are crucial for efficiently designing, executing, and interpreting DEL experiments that accelerate the identification of new therapeutic compounds.
What are DNA Encoded Libraries?
DNA Encoded Libraries (DELs) are collections of small molecules that are each attached to a unique DNA sequence acting as a molecular barcode. This technology allows researchers to rapidly screen millions to billions of compounds simultaneously to identify those that bind to a biological target, which is especially useful in early-stage drug discovery. The DNA tags make it possible to track and identify active compounds using DNA sequencing techniques, greatly increasing throughput and efficiency compared to traditional screening methods.
What is the difference between Dna Encoded Libraries vs Synthetic Chemistry Chemist?
| Aspect | Dna Encoded Libraries | Synthetic Chemistry Chemist |
|---|---|---|
| Required Credentials | Typically a background in molecular biology, biochemistry, or related fields; often with experience in library synthesis and screening | Usually a degree in chemistry or chemical engineering; expertise in organic synthesis and reaction mechanisms |
| Work Environment | Laboratory focused on high-throughput screening, drug discovery, and molecular biology techniques | Laboratories or industrial settings focused on chemical synthesis, process development, and compound optimization |
| Industry Usage | Primarily used in pharmaceutical and biotech industries for drug discovery | Used across pharmaceuticals, materials science, and chemical manufacturing |
In summary, Dna Encoded Libraries specialists focus on creating and screening vast collections of DNA-tagged molecules for drug discovery, requiring expertise in molecular biology. Synthetic Chemistry Chemists concentrate on designing and synthesizing chemical compounds through organic reactions, emphasizing chemical expertise. Both roles are essential in the pharmaceutical industry but differ in their techniques and focus areas.
What are some typical challenges faced by scientists working with DNA-encoded libraries (DELs), and how can they be addressed?
Scientists working with DNA-encoded libraries often encounter challenges such as maintaining the integrity of DNA tags during chemical synthesis, ensuring efficient library encoding, and accurately decoding hits after screening. Addressing these issues requires careful optimization of reaction conditions to prevent DNA degradation, thorough validation of encoding and decoding steps, and close collaboration with bioinformatics specialists to analyze sequencing data. Working in multidisciplinary teams and staying current with advances in DEL technology can also help scientists overcome technical hurdles and contribute to successful drug discovery campaigns.
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Full-time
Posted 6 days ago
Baylor College of Medicine rating
8.6
Based on 23 frontline employees who took The Breakroom Quiz
67th of 612 rated colleges and universities
Job description
Summary
The Center for Drug Discovery https://www.bcm.edu/research/centers/drug-discovery is a strategic research center established at Baylor College of Medicine (BCM) in Houston, Texas. The mission of the Center for Drug Discovery is to establish novel discovery technologies that enable rapid and cost-effective drug discovery within the academic community. We are seeking a highly skilled and motivated staff scientist with expertise in medicinal chemistry and/or organic chemistry to join the Center for Drug Discovery's DNA encoded chemical library (DEL) team.
Job Duties
- Plan, direct and conduct research experiments.
- Evaluate and analyze data.
- Develop research techniques and perform applications required for specific research projects.
- Conduct literature searches and summarize information in an appropriate format for a particular study.
- Document results of experiments and reports to principal investigators.
- Participate in early stage drug discovery efforts in collaboration with biological scientists throughout the academic community, with a goal of bringing new treatments to patients with unmet medical needs.
- Synthesize medicinal chemistry compounds that the Center for Drug Discovery request in a timely and efficient manner.
- Design and synthesize DNA-encoded libraries, contribute to DEL-based lead discovery, and engage in cross-functional scientific discussions.
- Contribute to multidisciplinary lead-finding project teams by engaging in the following activities: design, screen, and synthesize DNA-encoded chemical libraries; perform compound resynthesis and medicinal chemistry optimization; uncover and utilize novel chemical reactions in water; and/or evaluate compounds for efficacy in vitro and/or in vivo.
- Perform other job related duties as assigned.
Minimum Qualifications
- Doctoral Degree. Experience may not be substituted in lieu of degree.
- Three years of post doctoral research experience.
Preferred Qualifications
- PhD in medicinal/organic chemistry or a related discipline.
- Hands-on laboratory experience in medicinal/organic chemistry and/or a related field and a track record of quality publications and/or patents in these areas.
- Experience with one or more of the following: DEL design and synthesis, performing innovative chemistry reactions and compound synthesis
Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.
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About Baylor College
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Industry
Colleges, universities, and professional schools
Company size
5,001 - 10,000 Employees
Headquarters location
Houston, TX, US
Year founded
1900