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Director Process Chemistry Jobs (NOW HIRING)

Amat

Director, Process Support Engineering

Boise, ID

$180K - $247K/yr

The Director will lead a team of Process Support Engineering managers and engineers while ... Qualifications Required * BS degree in Engineering, Physics, Materials Science, Chemistry, or ...

GondolaBio

Sr. Director, Chemical Development

As a subject matter expert, the Sr. Director of Chemical Development will lead internal teams and ... Lead CDMO process chemistry teams in advancing small molecule drug substances from candidate ...

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How much do director process chemistry jobs pay per year?

As of Aug 21, 2026, the average yearly pay for director process chemistry in the United States is $84,782.00, according to ZipRecruiter salary data. Most workers in this role earn between $59,000.00 and $105,000.00 per year, depending on experience, location, and employer.

What does a director of process chemistry do?

A Director of Process Chemistry leads teams responsible for developing and optimizing chemical processes used in the production of pharmaceuticals or other chemicals. They oversee process development from laboratory scale to full manufacturing, ensuring efficiency, safety, and regulatory compliance. This role involves collaboration with R&D, manufacturing, and quality teams to deliver scalable and cost-effective chemical synthesis solutions. Directors also manage budgets, mentor staff, and may interact with regulatory agencies to support product approval.

What are the key skills and qualifications needed to thrive as a director of process chemistry?

A Director of Process Chemistry typically requires a Ph.D. in chemistry or chemical engineering, extensive experience in process development and scale-up, and a strong foundation in organic synthesis. Familiarity with analytical instrumentation, process safety systems, and regulatory compliance, as well as proficiency in software for data analysis and project management, are commonly expected. Exceptional leadership, communication, and problem-solving skills help foster innovation and guide multidisciplinary teams effectively. These competencies are vital for ensuring efficient, safe, and cost-effective chemical manufacturing processes that meet organizational goals and industry standards.

How does a director of process chemistry typically collaborate with cross-functional teams during drug development?

A Director of Process Chemistry works closely with teams such as Analytical Development, Formulation, Quality Assurance, and Regulatory Affairs to ensure smooth progression of drug candidates from lab to manufacturing scale. Collaboration involves regular meetings to align on project timelines, address technical challenges, and implement process improvements. This role often leads technology transfer discussions and troubleshooting sessions, ensuring process scalability and compliance with regulatory requirements. Effective communication and interdisciplinary teamwork are essential for success in this leadership position.

What is the difference between Director Process Chemistry vs Process Development Manager?

AspectDirector Process ChemistryProcess Development Manager
CredentialsAdvanced degree in Chemistry or Chemical Engineering, extensive industry experienceSimilar educational background, often with several years of industry experience
Work EnvironmentStrategic leadership, overseeing multiple projects and teamsHands-on process development, project management, and team coordination
Industry UsageUsed in pharmaceutical, chemical, and biotech industries for high-level oversightCommonly found in R&D and manufacturing settings for process optimization

The main difference is that the Director Process Chemistry focuses on strategic leadership and overall process chemistry direction, while the Process Development Manager handles day-to-day process development and project execution. Both roles require similar credentials but differ in scope and responsibilities.

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Director Process Chemistry jobs near you
Infographic showing various Director Process Chemistry job openings in the United States as of August 2026, with employment types broken down into 1% As Needed, 79% Full Time, 16% Part Time, 3% Contract, and 1% Nights. Highlights an 92% Physical, 2% Hybrid, and 6% Remote job distribution, with an average salary of $84,782 per year, or $40.8 per hour.

Scientist III, Process Chemistry (Antibody-siRNA Conjugates)

Arrowhead Pharmaceuticals

Madison, WI • On-site

$110K - $125K/yr

Full-time

Re-posted 25 days ago

Job description

Arrowhead Pharmaceuticals, Inc. (Nasdaq ARWR) is a commercial stage biopharmaceutical company that develops medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a mechanism present in living cells that inhibits the expression of a specific gene, thereby affecting the production of a specific protein. Arrowhead's RNAi-based therapeutics leverage this natural pathway of gene silencing.

Arrowhead is focused on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins that are involved with disease. The depth and versatility of our RNAi technologies enables us to potentially address conditions in virtually any therapeutic area and pursue disease targets that are not otherwise addressable by small molecules and biologics. Arrowhead is leading the field in bringing the promise of RNAi to address diseases outside of the liver, and our clinical pipeline includes disease targets in the liver and lung with a promising pipeline of preclinical candidates.

Arrowhead's corporate headquarters is in Pasadena, CA with research and development teams in Madison, WI & San Diego, CA, and a state of the art manufacturing facility in Verona, WI. Our employees are nimble, science-driven innovators who are collaborating to bring new therapies to patients in need.

The Position

Arrowhead Pharmaceuticals is seeking a motivated Scientist III to join our Process Chemistry team, focused on the development and scale-up of conjugated RNAi therapeutics. This role centers on process development for antibody-siRNA conjugates (AOCs/ARCs), a key expansion of Arrowhead's TRiM platform into targeted extrahepatic delivery. The successful candidate will span the full development continuum - taking discovery-stage conjugation protocols, optimizing them for robustness and reproducibility, and developing them into GMP, kilogram-scale manufacturing processes. This is a hands-on role at the bench combined with oversight of external CRO/CDMO partners.

Responsibilities

  • Optimize discovery-stage conjugation protocols for antibody-siRNA conjugates, improving yield, reproducibility, and product quality to enable scale-up.
  • Develop GMP-ready, kilogram-scale conjugation processes, including site-specific and stochastic conjugation strategies, linker chemistry, and payload attachment.
  • Work hands-on in the laboratory to design, execute, and optimize conjugation reactions, purification (chromatography, TFF/UF-DF), and analytical control strategies.
  • Oversee and direct CROs/CDMOs executing process development and manufacturing activities, including setting technical direction, reviewing data, and ensuring timelines and quality standards are met.
  • Characterize conjugates for DAR/siRNA-to-antibody ratio, aggregation, charge heterogeneity, and stability using relevant analytical methods (e.g., HIC, SEC, IEX, LC-MS, AEX).
  • Lead technology transfer to internal and external manufacturing partners, authoring process descriptions, batch records, and development reports.
  • Troubleshoot process and analytical challenges; design experiments to define process parameters, ranges, and robustness for kilogram-scale operation.
  • Collaborate cross-functionally with discovery chemistry, linker/conjugation chemistry, analytical development, and CMC teams

Requirements

  • PhD in Organic Chemistry, Bioconjugate Chemistry, Chemical Engineering, or a related field; or a Bachelor's/Master's degree with commensurate hands-on industry experience.
  • Demonstrated hands-on experience in siRNA conjugation development is required.
  • Working knowledge of oligonucleotide and/or antibody chemistry, linker design, and bioconjugation methods.
  • Familiarity with purification and analytical characterization of conjugates.
  • Strong problem-solving, documentation, and communication skills.

Preferred

  • Experience with antibody-oligonucleotide conjugates (AOCs) or antibody-drug conjugates (ADCs).
  • Experience developing and scaling processes to GMP/kilogram scale and managing CRO/CDMO relationships.
  • Knowledge of site-specific conjugation technologies (e.g., engineered cysteines, enzymatic/click chemistry).
  • Experience with tech transfer and CMC/GMP environments.
Wisconsin pay range
$110,000—$125,000 USD

Arrowhead provides competitive salaries and an excellent benefit package.

Candidates must have current, valid authorization to work in the country where this role is located.

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