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Director Clinical Affairs Jobs (NOW HIRING)

Noctrix Health

Director, Clinical Affairs

Pleasanton, CA · On-site

$89K - $121K/yr

The Director, Clinical Affairs will serve as a key cross-functional leader and liaison among Clinical Affairs, Clinical Research, Regulatory Affairs, Quality, Product Development, and external ...

New

Sysmex

Director, Clinical Affairs

Lincolnshire, IL

$84K - $114K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

The Director, Clinical Affairs will be responsible for developing, coordinating, and executing the clinical strategy for new and modified Sysmex IVD products. This position will be responsible for ...

Sysmex

Director, Clinical Affairs

Mundelein, IL

$81K - $111K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

The Director, Clinical Affairs will be responsible for developing, coordinating, and executing the clinical strategy for new and modified Sysmex IVD products. This position will be responsible for ...

Sysmex

Director, Clinical Affairs

Lincolnshire, IL · On-site

$84K - $114K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

The Director, Clinical Affairs will be responsible for developing, coordinating, and executing the clinical strategy for new and modified Sysmex IVD products. This position will be responsible for ...

Sysmex Corporation

Director, Clinical Affairs

Lincolnshire, IL · On-site

$168.49 - $264/hr

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

The Director, Clinical Affairs will be responsible for developing, coordinating, and executing the clinical strategy for new and modified Sysmex IVD products. This position will be responsible for ...

Sysmex

Sr. Director, Clinical Affairs

Mundelein, IL

$81K - $111K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

The Senior Director, Clinical Affairs will be responsible for developing, coordinating, and executing the clinical strategy for new and modified Sysmex IVD products. This position will be responsible ...

Sysmex

Sr. Director, Clinical Affairs

Lincolnshire, IL

$84K - $114K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

The Senior Director, Clinical Affairs will be responsible for developing, coordinating, and executing the clinical strategy for new and modified Sysmex IVD products. This position will be responsible ...

Sysmex

Sr. Director, Clinical Affairs

Lincolnshire, IL · On-site

$84K - $114K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

The Senior Director, Clinical Affairs will be responsible for developing, coordinating, and executing the clinical strategy for new and modified Sysmex IVD products. This position will be responsible ...

Sysmex

Sr. Director, Clinical Affairs

Lincolnshire, IL

$84K - $114K/yr

  • Medical

  • Dental

  • Vision

  • Retirement

  • PTO

The Senior Director, Clinical Affairs will be responsible for developing, coordinating, and executing the clinical strategy for new and modified Sysmex IVD products. This position will be responsible ...

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Director Clinical Affairs information

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$62K

$143.1K

$191K

How much do director clinical affairs jobs pay per year?

As of Aug 15, 2026, the average yearly pay for director clinical affairs in the United States is $143,112.00, according to ZipRecruiter salary data. Most workers in this role earn between $123,500.00 and $178,500.00 per year, depending on experience, location, and employer.

What is the difference between Director Clinical Affairs vs Clinical Project Manager?

AspectDirector Clinical AffairsClinical Project Manager
CredentialsTypically requires advanced degrees (e.g., MD, PhD, or PharmD) and extensive industry experienceBachelor's or Master's degree in life sciences or related field, with relevant project management certifications
Work EnvironmentStrategic leadership in clinical development, overseeing multiple projects and teamsOperational management of individual clinical trials, coordinating teams and timelines
Industry UsageCommonly used in pharmaceutical, biotech, and medical device companies for senior clinical rolesUsed across similar industries for managing specific clinical studies and projects

The main difference is that the Director Clinical Affairs focuses on strategic oversight and leadership of clinical programs, while the Clinical Project Manager handles the day-to-day management of clinical trials. Both roles require industry-specific knowledge, but the director position involves higher-level planning and decision-making.

What does a director of clinical affairs do?

A Director of Clinical Affairs is responsible for overseeing the planning, execution, and management of clinical trials and research activities within an organization, often in the medical device, pharmaceutical, or biotechnology industries. They ensure that clinical studies comply with regulatory requirements and ethical standards, manage clinical teams, and coordinate with other departments such as regulatory affairs and product development. Their role is crucial in bringing new medical products to market safely and effectively by generating clinical evidence to support product claims.

How does a director of clinical affairs typically collaborate with cross-functional teams during clinical trials?

A Director of Clinical Affairs plays a central role in coordinating efforts across departments such as regulatory affairs, clinical operations, medical affairs, and data management. They ensure that clinical trial protocols align with regulatory requirements and company objectives, often leading cross-functional meetings to resolve issues and maintain timelines. Effective collaboration involves clear communication, strategic planning, and the ability to translate complex clinical data for diverse stakeholders. This teamwork is crucial for the successful design, execution, and reporting of clinical studies.

What are the key skills and qualifications needed to thrive as a director of clinical affairs?

To thrive as a Director of Clinical Affairs, you need deep expertise in clinical research, regulatory compliance, and program management, typically supported by an advanced degree in a health-related field and significant industry experience. Familiarity with clinical trial management systems (CTMS), regulatory submission platforms, and certifications like RAC (Regulatory Affairs Certification) are highly valued. Exceptional leadership, cross-functional collaboration, and strategic communication skills set top performers apart in this role. These competencies ensure effective oversight of clinical programs, regulatory adherence, and successful cross-team execution in complex healthcare environments.
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Director Clinical Affairs jobs near you
Infographic showing various Director Clinical Affairs job openings in the United States as of August 2026, with employment types broken down into 3% As Needed, 72% Full Time, 17% Part Time, and 8% Contract. Highlights an 95% Physical, 1% Hybrid, and 4% Remote job distribution, with an average salary of $143,112 per year, or $68.8 per hour.

Director, Clinical Affairs

Noctrix Health

Pleasanton, CA • On-site

$89K - $121K/yr

Full-time

Posted 2 days ago

New

Job description

Noctrix Health is redefining the treatment of chronic neurological disorders with clinically validated therapeutic wearables. Our team of medical device specialists, neuroscientists, and consumer electronics engineers is dedicated to delivering prescription-grade therapy with an outstanding user experience. We have pioneered the world's first drug-free wearable therapy, clinically proven to alleviate symptoms in adults with drug-resistant Restless Legs Syndrome (RLS). Join us in transforming healthcare, improving lives, and driving meaningful change through innovative medical technology.
We are seeking an experienced and strategic Director, Clinical Affairs to lead the planning, execution, and oversight of clinical studies supporting the development, regulatory approval, reimbursement, and commercialization of Noctrix Health's medical devices. This leader will be accountable for the successful delivery of clinical programs, ensuring studies are executed efficiently, compliantly, on schedule, and within budget while generating high-quality clinical evidence that supports regulatory and business objectives.
The Director, Clinical Affairs will serve as a key cross-functional leader and liaison among Clinical Affairs, Clinical Research, Regulatory Affairs, Quality, Product Development, and external partners. This individual will provide leadership across clinical operations, including sponsor oversight, site management, CRO and vendor management, clinical data quality, study execution, and evidence generation.
This position reports to the Senior Vice President, Clinical & Regulatory Affairs.
This is a full-time, hybrid position that is located at our Pleasanton headquarters.
Responsibilities:
  • Lead the planning, execution, and oversight of medical device clinical studies from study start-up through close-out
  • Contribute to clinical development strategies supporting product development, regulatory submissions, reimbursement initiatives, commercialization, and post-market evidence generation
  • Provide effective sponsor oversight of clinical trials, including monitoring activities, site performance, protocol compliance, enrollment, and clinical data quality
  • Ensure clinical studies are conducted in accordance with applicable FDA requirements, Good Clinical Practice (GCP), ISO 14155, approved protocols, and company procedures
  • Develop and manage study timelines, budgets, resource plans, enrollment forecasts, and key milestones
  • Proactively identify clinical program risks, develop mitigation strategies, and resolve operational challenges that could impact study timelines, quality, or budget
  • Lead clinical site identification, selection, initiation, engagement, performance management, and close-out activities
  • Build and maintain productive relationships with investigators, study coordinators, research institutions, and other clinical partners
  • Select, manage, and oversee CROs, clinical vendors, consultants, and service providers to ensure quality, timeline, and budget expectations are achieved
  • Support the development and review of clinical study protocols, informed consent forms, case report forms, clinical reports, and other study documentation
  • Partner with Regulatory Affairs to support regulatory submissions requiring clinical evidence and ensure clinical programs are aligned with regulatory strategy
  • Ensure the integrity, completeness, quality, and traceability of clinical data and study documentation
  • Support adverse event review, safety monitoring, clinical risk management, audits, regulatory inspections, and applicable Quality System activities
  • Collaborate with Product Development, Quality, Regulatory Affairs, and Clinical Research to incorporate clinical insights into product development, risk management, labeling, and post-market activities
  • Support the generation of clinical evidence for reimbursement, payer engagement, market access, and commercialization initiatives
  • Establish and monitor clinical program KPIs, study performance metrics, and operational dashboards
  • Provide executive leadership with regular updates regarding study progress, enrollment, budgets, risks, clinical evidence generation, and key program milestones
  • Lead, mentor, and develop Clinical Affairs personnel while establishing clear performance expectations and promoting operational excellence
  • Identify and implement opportunities to improve clinical processes, systems, vendor management, and study execution as the organization scales

Requirements:
  • Bachelor's degree in Nursing, Life Sciences, Biomedical Engineering, or a related scientific or technical discipline
  • Minimum of 8 years of clinical affairs or clinical research experience within the medical device industry
  • Demonstrated leadership experience managing Clinical Affairs personnel, CROs, clinical vendors, and external partners
  • Proven experience managing medical device clinical programs from study start-up through execution and close-out
  • Experience with multiple clinical study models, including multicenter, decentralized, and hybrid clinical trials
  • Strong knowledge of FDA clinical trial requirements, Good Clinical Practice (ICH-GCP), ISO 14155, and applicable clinical research regulations
  • Demonstrated experience providing sponsor oversight of medical device clinical studies
  • Experience developing and managing clinical study budgets, timelines, enrollment forecasts, resources, and operational plans
  • Experience supporting clinical evidence generation for regulatory submissions
  • Strong understanding of clinical study documentation, data quality, safety reporting, monitoring, and inspection-readiness requirements
  • Proven ability to identify and mitigate clinical program risks while managing multiple priorities and studies simultaneously
  • Excellent leadership, project management, organizational, and problem-solving capabilities
  • Strong written and verbal communication skills with the ability to communicate clinical strategy, study performance, and risks to executive leadership
  • Demonstrated ability to effectively collaborate across Clinical Research, Regulatory Affairs, Quality, Product Development, and other functions

Preferred Qualifications:
  • Master's degree or other advanced degree in a relevant scientific, clinical, or technical discipline
  • Experience within a startup or growth-stage medical device organization
  • Experience supporting pivotal or other clinical studies used for FDA submissions and product approvals/clearances
  • Experience generating clinical evidence to support reimbursement, payer coverage, or market access initiatives
  • Experience with neurological, neuromodulation, wearable, or connected medical devices
  • Experience supporting FDA inspections, clinical site audits, and other regulatory or Quality System inspections
  • Experience building or scaling Clinical Affairs functions, processes, and teams
  • Experience working with international clinical studies and regulatory requirements

Compensation:
  • Base Pay: $240,000-$280,000 per year
  • Annual Bonus Eligibility

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