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Director Cell Line Development Jobs (NOW HIRING)

Boston Institute of Biotechnology

$150K - $160K/yr

The Associate Director of Cell Line Development at BIB will lead a team of scientists and associates to develop mammalian cell lines and strains for the expression of therapeutic proteins. As a core ...

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How much do director cell line development jobs pay per year?

As of Sep 15, 2026, the average yearly pay for director cell line development in the United States is $82,598.00, according to ZipRecruiter salary data. Most workers in this role earn between $55,000.00 and $97,500.00 per year, depending on experience, location, and employer.

What does a director of cell line development do?

A Director of Cell Line Development leads teams responsible for creating and optimizing cell lines used in the production of biopharmaceutical products, such as therapeutic proteins and antibodies. This role involves overseeing scientific strategy, ensuring regulatory compliance, and collaborating with cross-functional teams to meet project goals. Directors also provide technical guidance, manage budgets, and contribute to the development of new technologies and processes. Their work is critical in ensuring high-yield, stable, and safe cell lines for large-scale manufacturing.

What are the key skills and qualifications needed to thrive as a director of cell line development?

To excel as a Director Cell Line Development, you need advanced knowledge in cell biology, molecular biology, and bioprocessing, often backed by a Ph.D. and significant industry experience. Expertise with technologies such as CRISPR, high-throughput screening, cell culture automation systems, and regulatory standards like GMP is essential. Strong leadership, strategic planning, and effective communication are vital soft skills for guiding teams and collaborating across departments. These competencies ensure the efficient creation of robust cell lines critical for biologics development and organizational success.

What are the primary challenges a director of cell line development faces when overseeing multiple projects simultaneously?

A Director of Cell Line Development often manages several projects at different stages, which requires balancing timelines, resources, and technical challenges. Coordinating cross-functional teams—such as upstream process development, analytical, and quality assurance groups—can be complex, especially when each project has unique scientific hurdles and regulatory requirements. Effective communication, prioritization, and risk mitigation are key skills needed to ensure projects progress smoothly and meet critical milestones. Additionally, maintaining up-to-date knowledge of evolving technologies and regulatory guidelines is essential to lead teams successfully.

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Director Cell Line Development jobs near you
Infographic showing various Director Cell Line Development job openings in the United States as of June 2026, with employment types broken down into 1% As Needed, 82% Full Time, 16% Part Time, and 1% Contract. Highlights an 95% Physical, 2% Hybrid, and 3% Remote job distribution, with an average salary of $82,598 per year, or $39.7 per hour.

Research Associate, Cell Line Development

Emeryville, CA • On-site

Prolific Machines
Biotechnology Research and Development • 1 - 10 employees
Learn more about Prolific Machinesexternal

$70K - $100K/yr

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Posted 18 days ago

Job description

Prolific Machines is ushering in a new era of biotechnology with light. Our first-of-its-kind optogenetic platform delivers unprecedented control, precisely guiding cellular behavior when and where it matters most. Unlike existing tools used to control biology, our technology enables dynamic, tunable control over virtually any cellular function in any cell type. We're enabling partners to unlock robust efficiency, quality, and reproducibility advantages across the most complex pharmaceuticals and therapeutic proteins. Prolific is supported by leading investors, including Bill Gates's Breakthrough Energy Ventures, Mayfield and SOSV.


We are seeking a skilled Research Associate to join our Cell Line Development team, contributing technically and scientifically to the advancement of multiple projects while bringing innovation and new perspectives to our workflows. This role will be based on-site in Emeryville, CA and will report to a Principal Scientist of the Cell Line Development department.
Responsibilities:
  • Contribute to the maintenance of an internal cell line bank, including banking of new cell lines and ensuring the quality of cell lines for Research purposes.
  • Develop and engineer new cell lines;
  • Assessment and quantification of target antigen expression.
  • Design and perform cell-based and protein analysis assays.
  • Contribute to improvement of processes and techniques.
  • Analysis and interpretation of data and presentation to internal stakeholders.
  • Maintain a close collaboration with cross-functional project teams.
  • Maintain accurate and timely up-to-date documentation (familiarity with ELNs).
  • Update and optimize local guidelines / SOPs for the team.
  • Routine maintenance of the Tissue Culture labs.
Requirements:

For this position, we are looking for a highly motivated individual bringing along:

  • A Bachelor's degree in Biology or equivalent with 2 or more years of experience.
  • Previous experience in industry is a plus.
  • Extensive hands-on experience with mammalian cell culture techniques.
  • Careful and accurate working style, quality awareness.
  • Proficiency in Microsoft Office Suite (Excel, Word, Outlook, and Teams).
  • Data analytic software, such as GraphPad Prism.
Specific cell line development experience that will help you to succeed in this role will be:
  • Experience executing batch and fed-batch culture studies as part of cell line development and upstream process development activities.
  • Experience with bench-scale bioreactor set-up and operation (mammalian culture).
  • Familiarity with fully-automated instrumentation (FACS, Octet, Cell Printer, etc.) for the selection of high-producing clones used in antibody discovery and cell line development.
  • Experience with basic molecular biology techniques (PCR, ligation cloning, gel electrophoresis, etc.).

This role requires on-site/in-person presence in the Emeryville office. Occasional weekend work may be required to support operational needs. This position summary is not intended to be all inclusive. An employee may perform other related duties as negotiated to meet the ongoing needs of the organization. 

About You:
A successful candidate for this role will:
  • Have a flexible and independent working attitude.
  • Adapt successfully to changing situations and environments.
  • Have a strong eagerness to learn.
  • Have well-developed communication, teamwork, and organizational skills.
  • Be proactive and drive to optimize workflows.
This is an individual contributor role within the Research Associate track. The position is best suited for candidates who excel in hands-on execution, instrumentation, and technical operations in a laboratory setting. Growth opportunities within this role are focused on deepening technical expertise, expanding instrument proficiency, and taking on increasing operational responsibility within the Cell Line Development function.
$70,000 - $100,000 a year
This role is salaried, exempt, and paid semi-monthly. Starting salary will be dependent upon specific experience, knowledge, and skillset. The range depending on exact level will typically fall between $70k-$85k for Research Associate I or $85k-$100k for Research Associate II.

Benefits: Generous equity package in an early stage company, retirement plan with company contribution, flexible PTO with healthy time off minimums, company-covered medical, dental, and vision insurance, life and disability insurance, career coaching, mental health support, free team lunches everyday, great snacks, and companywide social events!

Diversity: Prolific Machines values diverse perspectives, backgrounds, experiences, and ideas. We are committed to building an inclusive workplace where all employees can bring their authentic selves to work and have equal opportunities to succeed. Prolific Machines is proud to be an equal opportunity employer and does not discriminate on the basis of race, color, religion, creed, sex, gender identity or expression, sexual orientation, national origin, ancestry, age, disability, medical condition, genetic information, marital status, military or veteran status, or any other characteristic protected by applicable law.

Location: The San Francisco Bay Area (Emeryville, CA)

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