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How much do director cell line development jobs pay per year?

As of Aug 26, 2026, the average yearly pay for director cell line development in the United States is $82,598.00, according to ZipRecruiter salary data. Most workers in this role earn between $55,000.00 and $97,500.00 per year, depending on experience, location, and employer.

What does a director of cell line development do?

A Director of Cell Line Development leads teams responsible for creating and optimizing cell lines used in the production of biopharmaceutical products, such as therapeutic proteins and antibodies. This role involves overseeing scientific strategy, ensuring regulatory compliance, and collaborating with cross-functional teams to meet project goals. Directors also provide technical guidance, manage budgets, and contribute to the development of new technologies and processes. Their work is critical in ensuring high-yield, stable, and safe cell lines for large-scale manufacturing.

What are the key skills and qualifications needed to thrive as a director of cell line development?

To excel as a Director Cell Line Development, you need advanced knowledge in cell biology, molecular biology, and bioprocessing, often backed by a Ph.D. and significant industry experience. Expertise with technologies such as CRISPR, high-throughput screening, cell culture automation systems, and regulatory standards like GMP is essential. Strong leadership, strategic planning, and effective communication are vital soft skills for guiding teams and collaborating across departments. These competencies ensure the efficient creation of robust cell lines critical for biologics development and organizational success.

What are the primary challenges a director of cell line development faces when overseeing multiple projects simultaneously?

A Director of Cell Line Development often manages several projects at different stages, which requires balancing timelines, resources, and technical challenges. Coordinating cross-functional teams—such as upstream process development, analytical, and quality assurance groups—can be complex, especially when each project has unique scientific hurdles and regulatory requirements. Effective communication, prioritization, and risk mitigation are key skills needed to ensure projects progress smoothly and meet critical milestones. Additionally, maintaining up-to-date knowledge of evolving technologies and regulatory guidelines is essential to lead teams successfully.

What cities are hiring for Director Cell Line Development jobs?

Cities with the most Director Cell Line Development job openings:

What are the most commonly searched types of Cell Line Development jobs?

The most popular types of Cell Line Development jobs are:

What states have the most Director Cell Line Development jobs?

States with the most job openings for Director Cell Line Development jobs include:

Director Cell Line Development jobs near you
Infographic showing various Director Cell Line Development job openings in the United States as of June 2026, with employment types broken down into 1% As Needed, 82% Full Time, 16% Part Time, and 1% Contract. Highlights an 95% Physical, 2% Hybrid, and 3% Remote job distribution, with an average salary of $82,598 per year, or $39.7 per hour.

Principal Scientist, Biologics Cell Line Development

Boston, MA • On-site

Asimov
See more jobs at Asimovexternal

$120 - $160/hr

Other

Re-posted 14 days ago

Job description

Our mission at Asimov is to advance humanity's ability to design living systems, enabling biotechnologies with outsized benefit to society. We’re developing a mammalian synthetic biology platform––from cells to software––to enable the design and manufacture of next-generation therapeutics.

We are seeking a Principal Scientist to join our Biologics Cell Line Development team in Boston, MA and help push the boundaries of biotherapeutic cell line development. This role is for a scientific innovator and a manager of junior scientists. The successful candidate will conduct & supervise CHO-based cell line development for biologic therapeutics moving into clinical development. Significant effort designing complex experimental approaches to improve expression systems and workflows through innovation and implementation of new technology is also an important part of this role.

The successful candidate will also work cross-functionally with Asimov’s synthetic biology, modeling, process development and analytical teams. This is a unique opportunity to work at a nimble, forward-thinking synthetic biology startup and help build the future of biological engineering.

About the Role
  • You’ll perform CHO cell line development processes including transfection, cloning, characterization, and cell banking using state-of-the-art equipment.
  • You’ll drive innovation through the development of improved genetic components, host cell line engineering and cell line development process optimization.
  • You’ll identify emerging practices for biologics cell line development and manufacturing to shape scientific strategies and continued innovation.
  • You’ll represent the cell line development team on cross-functional projects, making decisions for cell line activities and effectively communicating results, progress and plans.
  • You’ll represent Asimov externally, contributing to industry conferences, industry forums, filing patents, and publishing peer-reviewed manuscripts.
  • You’ll manage and mentor a team of 3+ scientists focused on CHO-based biologics CLD, providing technical direction and supporting them in their professional development.
About You
  • Experience of 8+ years CHO-based cell line development is a must, stemming from expressing IgGs and bispecifics in an industrial CLD environment.
  • You have a Ph.D. in Biological Engineering, Cell Biology, Molecular Biology, or a related field.
  • You’re a creative problem solver never satisfied with the status quo and get excited about the opportunity to drive the creation of disruptive technology.
  • Minimum 1 year experience managing direct report(s) and providing technical guidance.
  • Don’t let this stop you from applying, but it’s a plus if you are familiar with any of the following: vector optimization to improve titer and product quality attributes for complex bispecific scaffolds; CLD process optimization; or development of automated high-throughput screening for CLD workflows.
  • Experience working with a global customer base isn’t a requirement for this role but bonus points if you have it.

We’re fueled by a vision to transform biological engineering into a fully-fledged engineering discipline. Should you join our team, you will grow with a constantly evolving organization and push the frontiers of synthetic biology. Company culture is key to Asimov, and ours is a culture of recombination; we believe that our mission can only be achieved by bringing together a diverse team with a mixture of backgrounds and perspectives.

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