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Contract Downstream Processing Scientist Jobs (NOW HIRING)

Repligen Corporation

Scientist II

Waltham, MA · On-site

• The Scientist II, Downstream Processing will independently design, execute, and interpret studies to test and characterize new and prototype downstream processing technologies, equipment, and ...

Repligen

Scientist II

Waltham, MA

The Scientist II, Downstream Processing will independently design, execute, and interpret studies to test and characterize new and prototype downstream processing technologies, equipment, and ...

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How much do contract downstream processing scientist jobs pay per year?

As of Sep 4, 2026, the average yearly pay for contract downstream processing scientist in the United States is $87,842.00, according to ZipRecruiter salary data. Most workers in this role earn between $75,500.00 and $100,000.00 per year, depending on experience, location, and employer.

What is the difference between Contract Downstream Processing Scientist vs Contract Upstream Processing Scientist?

AspectContract Downstream Processing ScientistContract Upstream Processing Scientist
ResponsibilitiesFocuses on purification, formulation, and finishing of bioproductsHandles cell culture, fermentation, and initial product generation
Required SkillsProtein purification, chromatography, aseptic techniquesCell culture, bioreactor operation, media preparation
Work EnvironmentBiotech manufacturing, contract research organizationsBiotech labs, manufacturing facilities
Common CertificationsGMP, cGMP, laboratory safetyGMP, cGMP, laboratory safety

Contract Downstream Processing Scientists specialize in purification and finishing of bioproducts, while Contract Upstream Processing Scientists focus on cell culture and fermentation. Both roles require GMP knowledge and are found in biotech manufacturing settings, but they differ in their specific technical focus and stage of bioprocessing.

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Contract Downstream Processing Scientist jobs near you
Infographic showing various Contract Downstream Processing Scientist job openings in the United States as of August 2026, with employment types broken down into 1% As Needed, 80% Full Time, 14% Part Time, 1% Temporary, 3% Contract, and 1% Nights. Highlights an 93% Physical, 2% Hybrid, and 5% Remote job distribution, with an average salary of $87,842 per year, or $42.2 per hour.

Downstream Process Development Associate - Gene Therapy Purification 3656143

Axiom Path

San Diego, CA • On-site

$80 - $84.60/hr

Full-time

Posted 16 days ago

Job description

Be Part Of A Dynamic Team

Join a growing gene therapy organization supporting the development of innovative therapeutic programs through advanced process development and purification technologies. This team operates in a collaborative, startup-style environment where scientists work closely together to develop and optimize processes that support future manufacturing capabilities.

The successful candidate will join a hands-on process development group focused on downstream purification activities, laboratory execution, and advancing gene therapy programs through critical development milestones.

What's In Store For You

  • Engagement: W2 only (no C2C/1099)
  • Full-time onsite laboratory opportunity in San Diego, California.
  • Opportunity to contribute directly to gene therapy process development activities.
  • Exposure to advanced downstream purification technologies and specialized laboratory equipment.
  • Work alongside experienced scientists in a collaborative and evolving biotech environment.
  • Potential contract extension or future full-time consideration based on business needs and performance.

How You Will Make An Impact

  • Execute downstream process development activities supporting gene therapy programs.
  • Operate chromatography systems, tangential flow filtration (TFF), ultrafiltration, and depth filtration equipment.
  • Support purification process development studies and laboratory experimentation.
  • Generate experimental data and contribute to process optimization activities.
  • Troubleshoot equipment operation and support successful execution of development runs.
  • Collaborate with scientists and cross-functional partners to achieve project goals.
  • Maintain accurate laboratory documentation and communicate study results effectively.
  • Support continued development of downstream processing capabilities within a growing organization.

Are you an experienced downstream process development professional ready to make an impact?

  • Approximately 4–6 years of hands-on downstream process development experience preferred.
  • Experience operating chromatography systems in a laboratory environment.
  • Hands-on experience with tangential flow filtration (TFF) systems.
  • Experience with ultrafiltration and depth filtration processes.
  • Background in gene therapy, biologics, bioprocess development, or related purification environments preferred.
  • Ability to independently execute laboratory activities after onboarding and training.
  • Experience in process development environments strongly preferred; GMP experience is helpful but not required.
  • Bachelor's degree in a relevant scientific discipline preferred, although equivalent hands-on experience may be considered.
  • Strong problem-solving skills and ability to troubleshoot laboratory equipment and processes.
  • Collaborative communication style aligned with a team-focused scientific environment.
  • Comfortable working onsite five days per week in San Diego.