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$87.8K

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How much do contract downstream processing scientist jobs pay per year?

As of Jul 3, 2026, the average yearly pay for contract downstream processing scientist in the United States is $87,842.00, according to ZipRecruiter salary data. Most workers in this role earn between $75,500.00 and $100,000.00 per year, depending on experience, location, and employer.

What is the difference between Contract Downstream Processing Scientist vs Contract Upstream Processing Scientist?

AspectContract Downstream Processing ScientistContract Upstream Processing Scientist
ResponsibilitiesFocuses on purification, formulation, and finishing of bioproductsHandles cell culture, fermentation, and initial product generation
Required SkillsProtein purification, chromatography, aseptic techniquesCell culture, bioreactor operation, media preparation
Work EnvironmentBiotech manufacturing, contract research organizationsBiotech labs, manufacturing facilities
Common CertificationsGMP, cGMP, laboratory safetyGMP, cGMP, laboratory safety

Contract Downstream Processing Scientists specialize in purification and finishing of bioproducts, while Contract Upstream Processing Scientists focus on cell culture and fermentation. Both roles require GMP knowledge and are found in biotech manufacturing settings, but they differ in their specific technical focus and stage of bioprocessing.

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Contract Downstream Processing Scientist jobs near you

Staff Scientist- Downstream Process

ABL, Inc.

Rockville, MD • On-site

Full-time

Posted 8 days ago

Job description

ABL, Inc. is an Equal Opportunity Employer and is committed to embracing diverse backgrounds. ABL, Inc. does not discriminate on the basis of race, color, religion, gender, age, national origin, disability, veteran status, sexual orientation or any other characteristic protected by federal, state or local law. For more information click here.
Job Title
Staff Scientist- Downstream Process
Location
Rockville, MD 20850 US (Primary)
Job Type
Full-time
Funding available in current budget
115000
Exemption Type
Exempt
Career Level
Experienced (Non-Manager)
Education
Bachelor's Degree
Job Description
PURPOSE OF JOB
Serving as a project leader in Downstream Process Development, the Staff Scientist will collaborate on anddrive the planning, execution, and management of assigned purification activities. Working with external clients, R&D, Quality Control/Quality Assurance and Manufacturing, the Staff Scientist is expected to provide expertise and scientific knowledge for design, development, optimization, and manufacturing of protein and virus products. The incumbent will participate in downstream experiment design and execute the downstream process screening, optimization, scale-up, characterization, and stability studies for proteins and viral vectors to meet client specified end points.
The incumbent in this position is expected to have a strong understanding of the principals involved in protein and viral vector purification and extensive hands-on experience in downstream process development. This position involves developing scalable downstream purification processes for GMP production, optimizing process performance for yield and purity, and adapting existing procedures to meet regulatory requirements for the manufacture of protein and viral products intended for human injection. The successful candidate is expected to carry out the work with minimal guidance. This position is expected to interact with other departments involved in technology transfer, GMP manufacturing, product testing and quality assurance for product release.
ESSENTIAL JOB FUNCTIONS
  • This is a hands-on laboratory role requiring active participation in experimental execution and process development activities.
  • Perform downstream process development studies and generate high-quality data under minimal supervision.
  • Service as a downstream technical expert for client projects.
  • Generate, manage, and maintain critical data in a highly organized manner in the form of notebook, protocol and SOP.
  • Generate, interpret, and document experimental results in the form of technical reports, study summaries, and client-facing documentation.
  • Responsible for laboratory maintenance, material ordering, inventory control, and preparation of experiments.
  • Stay current with scientific and technical literature and leverage emerging knowledge to solve complex technical problems and improve process performance.
  • Formulate and establish process design and performance objectives in consultation with other functions, including Research and Manufacturing, as well as contractors, suppliers, and customers.
  • Provide expertise and troubleshooting for all in-house developed processes.

Job Requirements
QUALIFICATIONS AND EDUCATION REQUIREMENTS
  • Ph.D. in life science discipline with 2+ years of downstream experience; or MS degree in with 5+ years of experience; or BS degree in biochemistry/chemistry with 10+ years of experience in downstream process development.
  • Highly proficient in chromatography, tangential flow filtration (TFF), and filtration.
  • Experience in the development, purification, or characterization of viral vectors and/or protein-based biologics.
  • Strong attention to detail with a track record of executing experimental work with a high level of accuracy and reliability. Exhibits neatness, accuracy, consistency and promptness in work habits.
  • Proven ability to independently execute experimental work and deliver accurate results under minimal supervision, within tight timelines and defined budget requirements for internal and external client projects.

PREFERRED SKILLS & QUALIFICATIONS
  • Experience with cGMP manufacturing under cGMP /cGLP compliance is a plus.
  • Experience with standard analytical techniques including HPLC, SDS-PAGE, ELISA, and cell-based assays.
  • Advanced computer and presentation skills using MS Office (Word, Excel, Power Point).
  • Strong written and verbal communication skills with the ability to clearly communicate technical information across cross-functional teams.
  • Task & Team-oriented, analytical, organized, detail-oriented, self-motivated & ability to multitask.
SUPERVISORY RESPONSIBILITIES
  • No supervisory responsibilities.
PHYSICAL DEMANDS
  • Meet all the requirements of our Company Occupational Health program as directed by the Occupational Health Consultant. Employment is contingent upon favorable background, reference and pre-employment physical including drug screen.
  • Able to lift up to 35 lbs.
WORK ENVIRONMENT
  • Office
  • Laboratory
  • cGMP suite
  • Remote work

Travel Expectation
None
ABL, Inc. participates in E-Verify, an Internet-based system of the Department of Homeland Security (DHS) and Social Security Administration, that allows us to determine an employee's eligibility to work in the United States.
ADDITIONAL INFORMATION:
  • Candidate must meet all the requirements of our Company Occupational Health program as directed by the Occupational Health Consultant to include pre-employment physical and drug screen.
  • Candidates are encouraged to submit a resume and a cover letter outlining background and experience as it relates to the position requirements and salary history/requirements. Please note that "negotiable" is neither salary nor requirements. Salary commensurate with experience.

ABL, Inc. does not accept nor respond to unsolicited resumes from vendors, including recruitment agencies and search firms. Approved recruiting agencies must obtain prior approval from ABL, Inc. Human Resources in order to submit resumes to ABL, Inc. for consideration.

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