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Contract Downstream Processing Scientist Jobs (NOW HIRING)

Scientist II, Downstream Location: This is an on-site position located in Pearland, TX. The purpose ... The ideal candidate will be responsible for leading new process development and improving existing ...

Scientist II, Downstream Location: This is an on-site position located in Pearland, TX. The purpose ... The ideal candidate will be responsible for leading new process development and improving existing ...

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Perform hands-on purification processes, including column chromatography, tangential flow ... Bachelor's degree in life sciences or a closely related discipline * Demonstrated leadership in ...

Aptask Global Workforce (AGW) is seeking a Scientist - I (Assistant) for an Onsite position with a ... This is a 12+ month contract opportunity. This role involves supporting downstream processing of ...

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Contract Downstream Processing Scientist information

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$58.5K

$87.8K

$123.5K

How much do contract downstream processing scientist jobs pay per year?

As of Jul 3, 2026, the average yearly pay for contract downstream processing scientist in the United States is $87,842.00, according to ZipRecruiter salary data. Most workers in this role earn between $75,500.00 and $100,000.00 per year, depending on experience, location, and employer.

What is the difference between Contract Downstream Processing Scientist vs Contract Upstream Processing Scientist?

AspectContract Downstream Processing ScientistContract Upstream Processing Scientist
ResponsibilitiesFocuses on purification, formulation, and finishing of bioproductsHandles cell culture, fermentation, and initial product generation
Required SkillsProtein purification, chromatography, aseptic techniquesCell culture, bioreactor operation, media preparation
Work EnvironmentBiotech manufacturing, contract research organizationsBiotech labs, manufacturing facilities
Common CertificationsGMP, cGMP, laboratory safetyGMP, cGMP, laboratory safety

Contract Downstream Processing Scientists specialize in purification and finishing of bioproducts, while Contract Upstream Processing Scientists focus on cell culture and fermentation. Both roles require GMP knowledge and are found in biotech manufacturing settings, but they differ in their specific technical focus and stage of bioprocessing.

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Associate Scientist, Downstream Process Development

Epicrispr Biotechnologies

South San Francisco, CA

$118K - $124K/yr

Other

Posted 7 days ago


Job description

Title: Associate Scientist, Downstream Process Development

Location: South San Francisco, CA

Opportunity:

We are seeking a highly motivated and detail-oriented Associate Scientist to join the Downstream Process Development team focused on adeno-associated virus (AAV) gene therapy therapeutics. This role will support the development, optimization, and scale-up of purification processes for AAV vectors from early research through clinical manufacturing.

Responsibilities:

  • Design, execute, and analyze downstream purification experiments for AAV vectors for process steps including clarification, sterile filtration, tangential flow filtration (TFF), chromatography (affinity, ion exchange, size exclusion, mixed mode), and ultracentrifugation.
  • Perform small-scale studies for development of downstream AAV processes, process optimization, process characterization, and assessment of process robustness.
  • Support process development activities from bench scale through pilot scale and tech transfer to GMP manufacturing.
  • Present data and project updates in team meetings and cross-functional forums.
  • Maintain accurate and timely documentation in electronic lab notebooks and technical reports.
  • Collaborate cross-functionally with upstream process development and analytical development and other functions.
  • Stay current with advancements in AAV purification technologies, regulatory expectations, and industry best practices.

Qualifications:
The requirements listed below are representative of the knowledge, skill, and/or ability required to perform this job successfully.

  • B.S. degree in Biochemical Engineering, Chemical Engineering, Molecular Biology, Biotechnology, Biochemistry, or related discipline with 5+ years of relevant industry experience (or M.S. with 3+ years or Ph.D.)
  • Required experience with AKTA purification
  • Strong working knowledge of chromatography and filtration technologies
  • Hands-on experience with viral vector purification, preferably AAV
  • Experience with analytical techniques for AAV characterization such as Refeyn, qPCR/dPCR/ddPCR, ELISA, alkaline gel, CE-SDS, SEC-HPLC, AUC and other similar analytical assays
  • Familiarity with Design of Experiments (DOE) and JMP are a plus
  • Strong organizational, analytical, and problem-solving skills
  • Excellent written and verbal communication skills

Compensation: The salary range for this position is $118,000 to $124,000 USD annually. This salary range is an estimate, and the actual salary may vary based on various factors, including, without limitation, individual education, experience, tenure, skills, and abilities, as well as internal equity and alignment with market data, including potential adjustments for geographic location.Â