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Clinical Science Manager Jobs (NOW HIRING)

Pathos

Director, Clinical Science

New York, NY · On-site

$200K - $240K/yr

There is no middle management. There are no layers of approval. The company is designed, from the ... About the Role The Director, Clinical Science is a hands-on member of the Clinical Development team ...

TScan Therapeutics

Clinical Scientist

Waltham, MA · On-site

Experience * 5-8+ years of experience in clinical development, clinical science, data management, or related functions within biotechnology, pharmaceutical, or CRO environments. * Demonstrated ...

TScan Therapeutics

Clinical Scientist

Waltham, MA

Experience * 58+ years of experience in clinical development, clinical science, data management, or related functions within biotechnology, pharmaceutical, or CRO environments. * Demonstrated ...

BioNTech SE

Director, Clinical Science

Cambridge, MA · On-site +1

$168K - $268K/yr

As Director, Clinical Science (m/f/d), you will lead and shape clinical development strategies ... manage adverse event * Drive the creation of key study-level documents such as protocols ...

TScan Therapeutics

Clinical Scientist

Waltham, MA · On-site

Experience * 5-8+ years of experience in clinical development, clinical science, data management, or related functions within biotechnology, pharmaceutical, or CRO environments. * Demonstrated ...

McKesson Corporation

Clinical Science Liaison

$67K - $89K/yr

Position Summary Clinical Science Liaison (CSL) is a senior clinical leader responsible for ... Program Management: Manages multiple high-priority initiatives with precision. * Adaptability:

Clinovo

Sr Clinical Scientist

Cambridge, MA · On-site

The successful candidate will bring strong clinical science expertise and experience supporting ... Safety & Risk Management * Collaborate closely with Pharmacovigilance, Medical Safety, and Medical ...

Sutter Health

Director, Clinical Science

Livermore, CA · Hybrid

$209K - $334K/yr

This position will function as director in charge of all required clinical science, new test ... Management reserves the right to revise the or require that other tasks be performed when the ...

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Clinical Science Manager information

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$43.5K

$82.3K

$140K

How much do clinical science manager jobs pay per year?

As of Jul 22, 2026, the average yearly pay for clinical science manager in the United States is $82,350.00, according to ZipRecruiter salary data. Most workers in this role earn between $65,000.00 and $89,500.00 per year, depending on experience, location, and employer.

How does a Clinical Science Manager typically collaborate with cross-functional teams during clinical trial development?

Clinical Science Managers play a key role in bridging scientific objectives with operational execution by working closely with clinical operations, regulatory affairs, data management, and medical affairs teams. They often lead the development of clinical protocols and ensure scientific integrity throughout the study, facilitating regular meetings and communication to align project goals and timelines. Their collaborative efforts help anticipate and resolve challenges, streamline processes, and ensure that trials meet regulatory requirements and scientific standards.

What are Clinical Science Managers?

Clinical Science Managers are professionals who oversee and coordinate clinical research projects, often within the pharmaceutical, biotechnology, or medical device industries. They are responsible for managing clinical trials, ensuring regulatory compliance, and collaborating with cross-functional teams such as clinical operations, regulatory affairs, and medical affairs. Their role involves protocol development, data analysis, and ensuring the safety and efficacy of investigational products. Clinical Science Managers also play a critical part in interpreting study results and presenting findings to stakeholders. They typically have advanced degrees in life sciences and significant experience in clinical research.

What is the difference between Clinical Science Manager vs Clinical Research Associate?

AspectClinical Science ManagerClinical Research Associate
CredentialsTypically requires advanced degrees (e.g., Master’s or PhD) and industry experienceUsually holds a bachelor’s degree in life sciences or related field
Work EnvironmentLeads teams, manages projects, and oversees clinical studiesMonitors clinical trials at sites, ensures protocol compliance
Employer & Industry UsagePharmaceutical, biotech, and medical device companiesContract research organizations, pharmaceutical companies
Search & Comparison IntentUnderstanding managerial roles in clinical scienceFocus on trial monitoring and site management

The Clinical Science Manager typically oversees clinical projects and manages teams, requiring advanced credentials. In contrast, the Clinical Research Associate focuses on monitoring clinical trials at sites. Both roles are essential in the clinical research process but differ in responsibilities and experience levels.

What are the key skills and qualifications needed to thrive as a Clinical Science Manager, and why are they important?

To thrive as a Clinical Science Manager, you need a solid background in clinical research, life sciences, and project management, typically supported by an advanced degree (e.g., PharmD, PhD, or MD) and industry experience. Familiarity with clinical trial management systems, regulatory compliance tools, and data analysis platforms is crucial. Strong leadership, strategic thinking, and effective communication skills help you manage cross-functional teams and build relationships with stakeholders. These competencies ensure the successful design, execution, and oversight of clinical studies, ultimately advancing scientific and business goals.
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What cities are hiring for Clinical Science Manager jobs? Cities with the most Clinical Science Manager job openings:
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Clinical Science Manager jobs near you
Infographic showing various Clinical Science Manager job openings in the United States as of July 2026, with employment types broken down into 2% As Needed, 73% Full Time, 17% Part Time, and 8% Contract. Highlights an 95% Physical, 1% Hybrid, and 4% Remote job distribution, with an average salary of $82,350 per year, or $39.6 per hour.
Associate Director, Clinical Science

Associate Director, Clinical Science

Alnylam Pharmaceuticals

Cambridge, MA • On-site

Full-time

Medical, Dental, Vision, Life, Retirement, PTO

Posted 10 days ago

Job description

Overview
The Associate Director (AD), Clinical Science will be a member of the global clinical development team, working closely with other members of the clinical research group within clinical development (medical lead, medical monitor, statistician, medical safety director, safety manager and clinical pharmacologist) to support investigations that deliver the development strategies for therapeutic compound(s) under development. Under supervision, the AD, Clinical Science, may assist with study design, contribution to the protocol concept sheet, support the protocol development and collaborate on clinical study execution. In addition, the AD, Clinical Science may contribute to key regulatory documents, clinical filing activities that are part of new drug applications, and participating in responses to questions from Regulatory Agencies.
Summary of Key Responsibilities
  • Clinical science expert for assigned studies maintaining current scientific and clinical knowledge in the specific therapeutic and disease area(s) of assignment.
  • May provide input to the protocol design document; contributes to the development of the protocol, including protocol amendments, Protocol Administrative Change Letters, and Dear Investigator Letters
  • Ensures development of Study Informed Consent Documents and responses to external stakeholder (e.g., Health Authority and Independent Ethics Committee) requests
  • Provides clinical input to the the development of the Statistical Analysis Plan and Tables, Listings, and Figures
  • Provides clinical guidance to the development of the clinical data collection strategy, instruments, and data review plan, ensuring alignment with the protocol and SAP, optimized data collection principles, and clinical data review best practice.
  • Sets the clinical data review strategy and leads the team in the review of emerging clinical data and trends; reviews and queries data; presents data to internal and external stakeholders; partners with site-facing colleagues in support of data issue resolution; ensures all clinical queries are appropriately addressed in support of database lock
  • Collaborates with Medical Safety and Pharmacovigilance on the Safety Review Plan and Safety Narrative Plan; reviews safety data and ensures clinical documents are updated in response to emerging safety profile; leads clinical safety data discussion during Safety Review Team meetings in collaboration with Medically Qualified Individual(s); reviews safety narratives
  • Provides clinical input to the development of the Risk Management Plan; ensures clinical activities are consistent with the approved Plan and partners with key stakeholders to develop and implement risk mitigations
  • Collaborates with the medical monitor on the establishment of External Data Monitoring Committees and Adjudication Committees, including chartering, data provision and presentation of data, and documentation and dissemination of Committee recommendations, as appropriate
  • Provides clinical input to selection of sites, and ensures protocol training is delivered to site-facing colleagues
  • Participates in investigator meeting planning and develops and delivers protocol training; develops and delivers ongoing protocol training in response to e.g., protocol amendments, emerging data issues, and quality events
  • Serves as the primary clinical point of contact with investigators and study team for questions relating to clinical aspects of the protocol; manages clinical response development, delivery, documentation, and curation (e.g., in FAQ)
  • In collaboration with the medical monitor, ensures protocol deviation sub-categories are established; ensures protocol deviations identified during clinical data review are reported; ensures all reported protocol deviations are appropriately managed and reconciled; leads protocol deviation trends review
  • Ensures TMF compliance for clinical documents
  • Provides clinical input and review of the Clinical Study Report
  • Ensures disclosure of safety and efficacy data and trial conclusions; may contribute to primary publications
  • Provides clinical support to audits and inspections, including responding to and addressing audit and inspection findings
  • May contribute to clinical sections of regulatory filings (e.g., Briefing Documents, Pediatric Investigational Plan, Investigator Brochure, IND/NDA Annual Reports, Periodic Safety Update Reports, responses to Health Authority requests)
  • Contributes to continuous improvement / process enhancement activities and innovative approaches to maximize effectiveness of clinical trial execution

Requirements
  • Minimum of a college degree in life sciences or nursing degree, advanced degree preferred (i.e. PhD, PharmD or MS) with 8+ years of experience in the pharmaceutical/biotech industry
  • Previous experience working on complex trials in the area Huntington's Disease or other movement disorders preferred.
  • Proven track record of successfully executing multiple proof of concept and pivotal trials; (s)NDA submission and HA interactions experience is a plus
  • The skills required for success in the job include scientific and analytic ability, ability to think strategically and tactically, an interest in applied clinical research, ability to work effectively in multifunctional and multinational teams, as well as the ability to multitask and prioritize.
  • Proven experience in developing effective relationships with key investigators.
  • Experience in leading the team in a matrix setting.

#LI-JR1
U.S. Pay Range
$177,700.00 - $240,300.00
The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).
Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.
Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers
About Alnylam
We are the leader in RNAi therapeutics - a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another.
At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

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