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Clinical Science Manager Jobs (NOW HIRING)

Celldex Therapeutics

Director, Clinical Science

Hampton, NJ · On-site

$81K - $110K/yr

Working closely with Clinical Science physicians, Clinical Operations, Data Management, Biostatistics, Regulatory Affairs, Medical Writing, Biomarker/Translational Research, Pharmacovigilance, and ...

Relay Therapeutics

Manager, Clinical Science

Cambridge, MA · On-site

$71K - $97K/yr

As Manager, Clinical Science at Relay Tx, you will play a key role in driving the development of our assets and support the implementation and execution of the clinical strategy. You will work ...

Relay Therapeutics

Manager, Clinical Science

Cambridge, MA · On-site

$71K - $97K/yr

As Manager, Clinical Science at Relay Tx, you will play a key role in driving the development of our assets and support the implementation and execution of the clinical strategy. You will work ...

Olema Oncology

Director, Clinical Science

Boston, MA · On-site

$86K - $118K/yr

... Management, Biostatistics, Clinical Pharmacology, Regulatory and Program Management, in the ... Attending scientific meetings pertinent to clinical science activities And will also include:

Olema Oncology

Director, Clinical Science

Boston, MA · On-site

$220K - $250K/yr

... Management, Biostatistics, Clinical Pharmacology, Regulatory and Program Management, in the ... Attending scientific meetings pertinent to clinical science activities And will also include:

Olema Oncology

Director, Clinical Science

San Francisco, CA · On-site

$94K - $128K/yr

... Management, Biostatistics, Clinical Pharmacology, Regulatory and Program Management, in the ... Attending scientific meetings pertinent to clinical science activities And will also include:

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Clinical Science Manager information

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$43.5K

$82.3K

$140K

How much do clinical science manager jobs pay per year?

As of Sep 1, 2026, the average yearly pay for clinical science manager in the United States is $82,350.00, according to ZipRecruiter salary data. Most workers in this role earn between $65,000.00 and $89,500.00 per year, depending on experience, location, and employer.

What is a clinical science manager?

Clinical Science Managers are professionals who oversee and coordinate clinical research projects, often within the pharmaceutical, biotechnology, or medical device industries. They are responsible for managing clinical trials, ensuring regulatory compliance, and collaborating with cross-functional teams such as clinical operations, regulatory affairs, and medical affairs. Their role involves protocol development, data analysis, and ensuring the safety and efficacy of investigational products. Clinical Science Managers also play a critical part in interpreting study results and presenting findings to stakeholders. They typically have advanced degrees in life sciences and significant experience in clinical research.

What are the key skills and qualifications needed to thrive as a clinical science manager?

To thrive as a Clinical Science Manager, you need a solid background in clinical research, life sciences, and project management, typically supported by an advanced degree (e.g., PharmD, PhD, or MD) and industry experience. Familiarity with clinical trial management systems, regulatory compliance tools, and data analysis platforms is crucial. Strong leadership, strategic thinking, and effective communication skills help you manage cross-functional teams and build relationships with stakeholders. These competencies ensure the successful design, execution, and oversight of clinical studies, ultimately advancing scientific and business goals.

How does a clinical science manager typically collaborate with cross-functional teams during clinical trial development?

Clinical Science Managers play a key role in bridging scientific objectives with operational execution by working closely with clinical operations, regulatory affairs, data management, and medical affairs teams. They often lead the development of clinical protocols and ensure scientific integrity throughout the study, facilitating regular meetings and communication to align project goals and timelines. Their collaborative efforts help anticipate and resolve challenges, streamline processes, and ensure that trials meet regulatory requirements and scientific standards.

What is the difference between Clinical Science Manager vs Clinical Research Associate?

AspectClinical Science ManagerClinical Research Associate
CredentialsTypically requires advanced degrees (e.g., Master’s or PhD) and industry experienceUsually holds a bachelor’s degree in life sciences or related field
Work EnvironmentLeads teams, manages projects, and oversees clinical studiesMonitors clinical trials at sites, ensures protocol compliance
Employer & Industry UsagePharmaceutical, biotech, and medical device companiesContract research organizations, pharmaceutical companies
Search & Comparison IntentUnderstanding managerial roles in clinical scienceFocus on trial monitoring and site management

The Clinical Science Manager typically oversees clinical projects and manages teams, requiring advanced credentials. In contrast, the Clinical Research Associate focuses on monitoring clinical trials at sites. Both roles are essential in the clinical research process but differ in responsibilities and experience levels.

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What cities are hiring for Clinical Science Manager jobs?

Cities with the most Clinical Science Manager job openings:

What states have the most Clinical Science Manager jobs?

States with the most job openings for Clinical Science Manager jobs include:

What job categories do people searching Clinical Science Manager jobs look for?

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Clinical Science Manager jobs near you
Infographic showing various Clinical Science Manager job openings in the United States as of August 2026, with employment types broken down into 87% Full Time, 12% Part Time, and 1% Contract. Highlights an 87% Physical, 2% Hybrid, and 11% Remote job distribution, with an average salary of $82,350 per year, or $39.6 per hour.

Director, Clinical Science

Celldex Therapeutics

Hampton, NJ • On-site

Other

Medical, Retirement, PTO

Posted 25 days ago

Job description

Overview
The Director, Clinical Science is a strategic scientific leader responsible for clinical study design, clinical data review, and execution of clinical development programs supporting innovative therapies. This individual will play a central role in translating scientific and medical insights into robust clinical studies and development strategies, while leading the interpretation of clinical data to inform key program decisions.
Working closely with Clinical Science physicians, Clinical Operations, Data Management, Biostatistics, Regulatory Affairs, Medical Writing, Biomarker/Translational Research, Pharmacovigilance, and Medical Affairs, the Director, Clinical Science will provide leadership across all phases of development, with particular emphasis on protocol development and study design, data review and interpretation, and data-driven decision making.
Responsibilities
Clinical Study Design and Development Strategy
  • Lead the design and development of clinical study protocols, protocol amendments, and associated study documents across all phases of development.
  • Partner with Clinical Science physicians and cross functional stakeholders to define study objectives, endpoints, eligibility criteria, study procedures and visit schedule, safety monitoring plans, and statistical considerations.
  • Ensure study designs are scientifically rigorous, operationally feasible, and aligned with regulatory and development objectives.
  • Contribute to clinical development plans, indication expansion strategies, and overall asset development decisions.
  • Integrate translational, biomarker, pharmacokinetic/pharmacodynamic (PK/PD), and patient-centered endpoints into clinical development programs.
  • Evaluate emerging scientific, competitive, clinical, and regulatory information to inform development strategies.

Clinical Data Review and Interpretation
  • Lead ongoing review and interpretation of clinical trial data, including efficacy, safety, biomarker, PK/PD, immunogenicity, and patient-reported outcomes.
  • Develop and implement data review strategies in collaboration with Biostatistics and Data Management.
  • Identify emerging trends, clinical signals, and development risks and provide recommendations to study teams and senior leadership.
  • Lead clinical review meetings and contribute to study conclusions, integrated analyses, and clinical development recommendations.
  • Present clinical data and program updates to governance committees, senior management, and cross-functional teams.
  • Support benefit-risk assessments and key development decisions throughout the product lifecycle.

Clinical Trial Execution and Scientific Oversight
  • Serve as the Clinical Science lead for assigned studies and development programs.
  • Provide scientific oversight during study conduct to ensure high-quality execution and data integrity.
  • Collaborate with Clinical Operations to support study startup, enrollment, protocol adherence, and issue resolution.
  • Participate in investigator meetings, advisory boards, and interactions with key opinion leaders and external experts.
  • Contribute to inspection readiness and compliance with GCP, ICH guidelines, and applicable regulatory requirements.

Regulatory and Scientific Contributions
  • Author and review clinical sections of regulatory documents, including INDs, CTAs, Investigator Brochures, Clinical Study Reports, briefing packages, periodic safety reports, annual reports, and marketing applications.
  • Support interactions with global health authorities and responses to regulatory inquiries.
  • Collaborate with Regulatory Affairs and Medical Writing to ensure high-quality and compliant clinical documentation.
  • Contribute to scientific publications, abstracts, posters, presentations, and congress materials.

Cross-Functional Leadership
  • Partner closely with Clinical Science physicians, Data management, Biomarker/Translational Research, Clinical Operations, Biostatistics, Safety, Regulatory Affairs, Medical Writing, and Medical Affairs.
  • Represent Clinical Science on cross-functional project teams, governance committees, and portfolio discussions.
  • Drive alignment across functions to support efficient decision-making and program execution.
  • Mentor and develop Clinical Scientists and contribute to building a culture of scientific excellence and continuous improvement.

Qualifications
  • Advanced degree in a scientific, healthcare, or related discipline preferred (e.g., PhD, PharmD, MD, DO, MS, MPH, NP, PA, or equivalent).
  • 10+ years of clinical research, clinical development, or clinical science experience within the biotechnology, pharmaceutical, or CRO industry.
  • Demonstrated experience leading clinical study design, protocol development, and clinical data review activities.
  • Experience serving as Clinical Science Lead for Phase 1 through Phase 3 clinical trials.
  • Proven track record of interpreting complex clinical datasets and translating findings into development strategy.
  • Experience supporting regulatory submissions and health authority interactions.
  • Experience in Immunology, autoimmune diseases, inflammatory disorders, or related therapeutic areas strongly preferred.
  • Biotechnology industry experience preferred.
  • Deep understanding of clinical trial methodology, study design, endpoint development, and statistical concepts.
  • Expertise in clinical data review and interpretation of efficacy, safety, biomarker, PK/PD, and translational data.
  • Strong knowledge of GCP, ICH guidelines, and global regulatory requirements.
  • Excellent scientific writing, communication, and presentation skills.
  • Strategic thinker with strong scientific judgment and analytical skills.
  • Proven ability to influence cross-functional teams and senior stakeholders.
  • Strong leadership, collaboration, and decision-making capabilities.
  • Ability to thrive in a fast-paced, innovative biotechnology environment.

Compensation Statement
The expected base salary for this position is: $176659.00 to $229427.00. We are committed to compensating employees equitably based on several factors including experience, education, licensure/certifications, skill level, location of the position, and availability of similar talent in a competitive market.
Subject to eligibility and applicable plan terms, compensation includes base salary, annual discretionary bonus, long term incentive, 401(K) plan with employer contribution, health care and other insurance benefits (for employee and family), paid holidays, vacation, and sick days. A summary of our benefits can be found on our careers page
Celldex is proud to be an equal opportunity employer that strives to foster a culture of diversity, equity, and inclusion. We are committed to promoting a diverse environment through development, recruiting and community outreach.

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