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Clinical Informatics Nurse Jobs in Boston, MA (NOW HIRING)

Clinical degree (MD, DO, RN, PharmD, NP/PA) with active or previous licensure preferred; OR equivalent deep domain experience in Health Informatics. * Informatics Experience: 5+ years of experience ...

Clinical degree (MD, DO, RN, PharmD, NP/PA) with active or previous licensure preferred; OR equivalent deep domain experience in Health Informatics. * Informatics Experience: 5+ years of experience ...

Clinical Pathologist

Burlington, MA ยท On-site

$358K - $406K/yr

Current needs include assistance in core laboratory management and informatics. An interest in ... Nurses, doctors, technicians, therapists, researchers, teachers and more, making a difference in ...

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Clinical Informatics Nurse information

See Boston, MA salary details

$46.2K

$106.9K

$180.9K

How much do clinical informatics nurse jobs pay per year?

As of Aug 29, 2026, the average yearly pay for clinical informatics nurse in Boston, MA is $106,911.00, according to ZipRecruiter salary data. Most workers in this role earn between $76,000.00 and $133,100.00 per year, depending on experience, location, and employer.

What is a Clinical Informatics Nurse?

A Clinical Informatics Nurse is a registered nurse who specializes in managing and optimizing healthcare information systems, such as electronic health records (EHRs). They act as a bridge between clinical staff and IT professionals, ensuring that technology supports quality patient care. Their responsibilities often include training staff, troubleshooting system issues, and analyzing clinical data to improve processes. Clinical Informatics Nurses play a key role in implementing new technologies and maintaining compliance with healthcare regulations.

How does a Clinical Informatics Nurse typically collaborate with healthcare providers and IT teams?

Clinical Informatics Nurses act as vital liaisons between clinical staff and IT professionals, ensuring that electronic health records (EHRs) and other health information systems meet the practical needs of patient care. They regularly communicate with nurses, physicians, and administrators to gather feedback on software usability and workflow integration. By translating clinical requirements into technical specifications, they help IT teams develop and optimize system functionalities. This collaboration is ongoing and crucial for successful technology adoption and improved patient outcomes.

What are the key skills and qualifications needed to thrive as a Clinical Informatics Nurse, and why are they important?

To thrive as a Clinical Informatics Nurse, you need a solid background in nursing practice combined with expertise in health informatics, often supported by a BSN degree, RN licensure, and informatics certification such as ANCC. Familiarity with electronic health records (EHRs), clinical decision support systems, and data analytics tools is essential. Strong problem-solving, communication, and change management skills help bridge the gap between clinical staff and IT teams. These skills are crucial for successfully implementing technology solutions that improve patient care and operational efficiency.

What is the difference between Clinical Informatics Nurse vs Registered Nurse?

AspectClinical Informatics NurseRegistered Nurse
CredentialsRN license, certification in informatics (e.g., ANCC)RN license, may have additional certifications
Work EnvironmentHospitals, clinics, healthcare IT settingsHospitals, clinics, community health
Job FocusImplementing and managing health IT systems, data analysisPatient care, direct clinical duties
Employer & IndustryHealthcare providers, IT vendors, hospitalsHospitals, clinics, long-term care facilities

The main difference is that Clinical Informatics Nurses focus on integrating technology into patient care, while Registered Nurses primarily provide direct patient care. Both roles require RN licensure, but Clinical Informatics Nurses also need specialized informatics certifications and work more with health IT systems.

How to get into clinical informatics as a nurse?

To become a clinical informatics nurse, professionals typically need a registered nurse (RN) license, experience in clinical settings, and additional training or certification in health informatics such as the Certified Healthcare Technology Specialist (CHTS) or the American Nurses Credentialing Center's Informatics Nursing Certification. Gaining knowledge of electronic health records (EHR) systems, data management, and health IT tools is essential, and some roles may require a bachelor's or master's degree in nursing or health informatics.

What are popular job titles related to Clinical Informatics Nurse jobs in Boston, MA?

For Clinical Informatics Nurse jobs in Boston, MA, the most frequently searched job titles are:

What job categories do people searching Clinical Informatics Nurse jobs in Boston, MA look for?

The top searched job categories for Clinical Informatics Nurse jobs in Boston, MA are:

Infographic showing various Clinical Informatics Nurse job openings in Boston, MA as of August 2026, with employment types broken down into 75% Full Time, and 25% Part Time. Highlights an 100% In-person job distribution, with an average salary of $106,911 per year, or $51.4 per hour.

Clinical Informatics Specialist

Boston, MA โ€ข On-site

Full-time

Re-posted 24 days ago


Job description

We are seeking a highly skilled Clinical Informatics Specialist to play a pivotal role in the architecture and development of our canonical data model and transformation framework within the InterSystems ecosystem. Focus areas include data modeling, comprehensive documentation, and validating clinical workflows to ensure real-world clinical alignment.

In this role, you will act as the bridge between clinical experts and technical engineering teams.ย  You will be responsible for translating clinical needs into product requirements, defining complex data mappings, validating clinical logic, and ensuring our data models adhere to global HIT standards (FHIR, HL7v2, CDA, OMOP, etc.) while maintaining the highest standards of patient safety and data privacy.

Key Responsibilities
  1. Data Modeling & Transformation Strategy
  • Manage the governance of the canonical data model definition and maintenance processes in alignment with product strategy, ensuring it supports diverse clinical domains across the care continuum.
  • Design and document detailed logic for data transformations and mappings between various healthcare data standards (e.g., HL7v2, C-CDA, FHIR, X12, OMOP, openEHR).
  • Analyze emerging national and international Implementation Guides and regulatory standards, translating them into technical specifications for the engineering team to support future product capabilities.
  1. Clinical Terminology Management
  • Serve as the subject matter expert on standard terminologies and code sets, (e.g., SNOMED CT, LOINC, ICD-10, CPT/HCPCS, RxNorm).
  • Define concept maps and value sets to ensure semantic interoperability across the platform.
  • Troubleshoot terminology binding issues that arise during data ingestion or exchange.
  1. Clinical Requirements & Translation
  • Collaborate with clinical subject matter experts (SMEs) to gather requirements and translate "clinical intent" into precise technical specifications.
  • Author functional specifications that allow engineers to build robust interoperability pipelines within InterSystems product suite.
  • Act as a translator, explaining complex technical data constraints to clinicians and complex clinical workflows to engineers.
  1. Quality Assurance & Safety Validation
  • Validate data models and transformation logic to ensure they are clinically sound and accurately reflect the patient story.
  • Conduct clinical safety assessments on proposed data structures to identify and mitigate risks related to data loss, misinterpretation, or context stripping.
  • Ensure all data designs comply with privacy regulations (HIPAA, GDPR) and data governance policies.
Qualifications

Education & Experience

  • Clinical Background: Clinical degree (MD, DO, RN, PharmD, NP/PA) with active or previous licensure preferred; OR equivalent deep domain experience in Health Informatics.
  • Informatics Experience: 5+ years of experience in clinical informatics, data modeling, or interoperability analysis.
  • InterSystems Expertise: Proven experience working within InterSystems IRIS for Health or HealthShare environments is highly desired. Experience with other major integration engines combined with a willingness to learn InterSystems technology will also be considered.

Technical Skills & Knowledge

  • Standards: Deep mastery of HL7v2, C-CDA, and FHIR (resources, profiles, and implementation guides). Familiarity with OMOP CDM or openEHR archetypes is a strong plus.
  • Terminologies: Proficiency with LOINC, SNOMED CT, ICD-10, and RxNorm browsers and hierarchy structures.
  • Tools: Experience with mapping tools, SQL, and data modeling software.
  • Regulatory: Understanding of ONC certification rules (USCDI), TEFCA, and CMS interoperability rules.

Competencies

  • Translation: Ability to demystify technical jargon for clinicians and clinical workflows for developers.
  • Analytical Thinking: Strong capability to visualize data flows and identify edge cases in complex clinical scenarios.
  • Communication: Excellent written and verbal communication skills for creating documentation and specifications.
  • Leverage AI-assisted tools (e.g., large language models, copilots) to accelerate documentation, specification authoring, and data mapping workflows - while applying clinical judgment to validate outputs for accuracy and patient safety.
  • AI Fluency: Comfort using AI/LLM-based tools (e.g., coding assistants, document drafting copilots, terminology mapping aids) to improve productivity; ability to critically evaluate AI-generated outputs for clinical correctness and safety.

We are an equal-opportunity employer and do not discriminate because of race, color, religion, sex, national origin, ancestry, marital status, veteran status, age, disability, sexual orientation or gender identity or expression or any other legally protected category. InterSystems is an E-Verify Employer in the United States.