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Clinical Histocompatibility Scientist Jobs (NOW HIRING)

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Clinical Histocompatibility Scientist information

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$42.5K

$94.4K

$153K

How much do clinical histocompatibility scientist jobs pay per year?

As of Aug 5, 2026, the average yearly pay for clinical histocompatibility scientist in the United States is $94,420.00, according to ZipRecruiter salary data. Most workers in this role earn between $59,000.00 and $119,000.00 per year, depending on experience, location, and employer.

What is a clinical histocompatibility scientist?

Clinical Histocompatibility Scientists are specialized laboratory professionals who perform testing to determine tissue compatibility, primarily for organ and stem cell transplantation. They analyze blood and tissue samples to identify genetic markers and antibodies that could affect transplant success. Their work helps match donors and recipients to minimize the risk of rejection and ensure the best possible outcomes. These scientists also provide essential support to clinicians by interpreting complex test results and advising on compatibility issues.

What is the difference between Clinical Histocompatibility Scientist vs Histotechnologist?

AspectClinical Histocompatibility ScientistHistotechnologist
CredentialsTypically requires a Bachelor's degree in biology, immunology, or related field; certification such as ASHI is commonRequires an associate degree or post-secondary training in histotechnology; certification like HT(ASCP) is often preferred
Work EnvironmentLaboratories performing tissue typing, transplantation testing, and immunogeneticsPathology labs preparing tissue samples for diagnosis
Employer & IndustryHospitals, transplant centers, research institutionsHospitals, diagnostic labs, research facilities

The Clinical Histocompatibility Scientist and Histotechnologist roles differ mainly in their focus: the former specializes in tissue typing and transplantation immunology, while the latter prepares tissue samples for pathology analysis. Both roles require specialized certifications and work in laboratory settings, but their specific tasks and industry applications vary.

What are the key skills and qualifications needed to thrive as a clinical histocompatibility scientist?

To thrive as a Clinical Histocompatibility Scientist, you need expertise in immunology, genetics, and laboratory practices, often supported by a bachelor's or advanced degree in biomedical sciences and certification such as ABHI. Familiarity with molecular typing methods, flow cytometry, PCR, and laboratory information systems is typically required. Attention to detail, analytical thinking, and strong communication skills help you interpret complex results and collaborate effectively with clinical teams. These competencies are crucial for ensuring accurate compatibility testing for organ transplantation and improving patient outcomes.

What are the typical challenges faced by a clinical histocompatibility scientist when interpreting complex test results?

Clinical Histocompatibility Scientists often encounter complex test results, especially when assessing compatibility for organ or stem cell transplantation. Challenges may include ambiguous serological or molecular findings, handling rare HLA variants, or resolving discrepancies between different testing platforms. Collaboration with transplant physicians and laboratory colleagues is essential to ensure accurate interpretation and effective communication of results. Staying current with advancements in immunogenetics and laboratory technologies also helps address these challenges.
More about Clinical Histocompatibility Scientist jobs
What cities are hiring for Clinical Histocompatibility Scientist jobs? Cities with the most Clinical Histocompatibility Scientist job openings:
What states have the most Clinical Histocompatibility Scientist jobs? States with the most job openings for Clinical Histocompatibility Scientist jobs include:
What job categories do people searching Clinical Histocompatibility Scientist jobs look for? The top searched job categories for Clinical Histocompatibility Scientist jobs are:
Infographic showing various Clinical Histocompatibility Scientist job openings in the United States as of July 2026, with employment types broken down into 2% As Needed, 73% Full Time, 17% Part Time, and 8% Contract. Highlights an 95% Physical, 1% Hybrid, and 4% Remote job distribution, with an average salary of $94,420 per year, or $45.4 per hour.

Clinical Histocompatibility Scientist (CHS) Trainee

University of California San Francisco

San Francisco, CA • On-site

Full-time

Re-posted 12 days ago


University Of California San Francisco rating

7.8

Company rating: 7.8 out of 10

Based on 13 frontline employees who took The Breakroom Quiz

225th of 614 rated colleges and universities


Job description


This is a training position. The Trainee will be enrolled in a state-approved training program for the Clinical Histocompatibility Scientist (CHS). (https://www.cdph.ca.gov/Programs/OSPHLD/LFS/Pages/Approved-CLS-Training-Schools-Programs.aspx)
While enrolled in the program, the trainee will be trained to perform:
  • HLA typing by molecular methods (e.g., RT-PCR and NGS)
  • KIR genotyping by SSP method
  • Crossmatch by flow cytometry method
  • Antibody screening by Luminex-based method
  • Chimerism testing by NGS method
  • Other procedures that are performed by licensed histocompatibility personnel.
  • Other duties include
    • Accession samples using Laboratory Information Systems (LIS)
    • Isolate DNA from blood, buccal mucosa, and cells
    • Isolate and cryopreserve lymphocytes from blood, spleen, and lymph nodes
    • Prepare serum samples for testing
    • Maintain samples in the inventory
    • Prepare reagents for testing
    • Perform QC and maintenance on various laboratory equipment
    • Perform maintenance duties for lab space
    • Order and stock lab supplies
    • File lab reports
    • Archive and scan documents

The Trainee must satisfy the requirements of the state-approved training program for continuous enrollment. Employment beyond the training period is dependent upon the receipt of California license and availability of a CHS/CLS position at ITL.
The Trainee must satisfy the requirements of the state-approved training program for continuous enrollment. Employment beyond the training period is dependent upon the receipt of California license and availability of a CHS/CLS position at ITL.
Department Description :
The mission of the UCSF Department of Surgery is threefold: to develop the next generation of leaders in surgery; to provide outstanding quality clinical care that is cost effective, yet compassionate; and to make significant advances in scientific knowledge and clinical practice through basic and clinical research. The Department is comprised of multiple divisions and sections and our surgeons provide care at locations throughout the greater San Francisco Bay Area and beyond. Our Residents and Fellows also play a critical role in Department's success. The Department of Surgery Chair's Office is an extremely high profile, fast paced environment with a very diverse range of contacts and needs which require an immediate and accurate response, handled with confidentiality, and while staying compliant. The Chair's Office is responsible for management, direction and oversight of over 400 faculty (clinical and research), trainees and staff personnel.
Qualifications
Required Qualifications :
  • BA/BS in life science, clinical science or appropriate scientific field
  • Relevant laboratory experience
  • Must meet the academic requirements to enroll in the training program
  • Must be able to work variable shifts as required by laboratory operations including weekends, nights and early mornings.
  • Accurate and be able to process multiple samples without switches.
  • Be able to work with personal computers.
  • Must be effective as a member of a team.
  • Proven record of being reliable and be able to multi-task.
  • Must be able to work independently with minimum supervision.
  • Tidy and orderly.

Preferred Qualifications :
  • Experience working with human samples
  • Experience with QC/QA/QS in a clinical laboratory setting
  • Working knowledge of antigens and genetics of the HLA system and be able to interpret results correctly.

About Us
About UCSF
The University of California, San Francisco (UCSF) is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care. It is the only campus in the 10-campus UC system dedicated exclusively to the health sciences. We bring together the world's leading experts in nearly every area of health. We are home to five Nobel laureates who have advanced the understanding of cancer, neurodegenerative diseases, aging and stem cells.
Pride Values
UCSF is a diverse community made of people with many skills and talents. We seek candidates whose work experience or community service has prepared them to contribute to our commitment to professionalism, respect, integrity, diversity and excellence - also known as our PRIDE values.
In addition to our PRIDE values, UCSF is committed to equity - both in how we deliver care as well as our workforce. We are committed to building a broadly diverse community, nurturing a culture that is welcoming and supportive, and engaging diverse ideas for the provision of culturally competent education, discovery, and patient care. Additional information about UCSF is available here.
Join us to find a rewarding career contributing to improving healthcare worldwide.
Equal Employment Opportunity
The University of California is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected status under state or federal law.
Salary Information
The final salary and offer components are subject to additional approvals based on UC policy.
Your placement within the salary range is dependent on a number of factors including your work experience and internal equity within this position classification at UCSF. For positions that are represented by a labor union, placement within the salary range will be guided by the rules in the collective bargaining agreement.
To learn more about the benefits of working at UCSF, including total compensation, please visit: https://ucnet.universityofcalifornia.edu/compensation-and-benefits/index.html

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