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Cell Based Potency Assay Jobs (NOW HIRING)

CYNET SYSTEMS

Scientist 2 - Chemistry

Malvern, PA · On-site

$37 - $44/hr

Plate-based biochemical assays (impurity, HCP), ELISA, FRET, Cell-based potency assays. * Experience working in a cGMP environment. Founded in 2010 and headquartered in the Washington, DC metro area ...

DISCGENICS INC

Analytical Scientist

Salt Lake City, UT · On-site

The position includes leading and supporting cell-based development (e.g., ELISA, flow cytometry, potency assays), evaluating new analytical technologies, and enabling method transfer to Quality ...

Legend Biotech USA, Inc.

... cell-based assays.Experience implementing or executing compendial methods is preferred.Experience with lentiviral vector characterization, including infectious titer, potency, and transduction ...

Cellares

Quality Control Analyst

Bridgewater, NJ · On-site

$90K - $210K/yr

Work with cell therapy products and associated assays (dPCR, qPCR, cell-based potency assays, proliferation assays, ELISA, flow cytometry assays, etc.) * Perform timely and accurate peer review of ...

Cellares

Quality Control Analyst

Bridgewater, NJ · On-site

$90K - $210K/yr

Work with cell therapy products and associated assays (dPCR, qPCR, cell-based potency assays, proliferation assays, ELISA, flow cytometry assays, etc.) * Perform timely and accurate peer review of ...

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All JobsCell Based Potency Assay Jobs

Cell Based Potency Assay information

What are cell based potency assays?

Cell based potency assays are laboratory tests that use living cells to measure the biological activity of a drug, vaccine, or biologic product. These assays help determine how effective a compound is in producing a desired cellular response, making them crucial for drug development and quality control. By closely mimicking the drug’s mechanism of action in the body, they provide more relevant information about efficacy and safety compared to non-cellular assays.

What are some common challenges faced when developing and validating cell based potency assays in a laboratory setting?

Developing and validating cell-based potency assays can be challenging due to the inherent biological variability of living cells, which can impact assay reproducibility and consistency. Additionally, optimizing assay conditions—such as cell passage number, incubation times, and reagent quality—requires careful attention to detail. Collaboration across multidisciplinary teams, including scientists, quality control, and regulatory affairs, is often necessary to ensure the assay meets rigorous industry and compliance standards. Successful candidates should be comfortable troubleshooting technical issues and adapting protocols to achieve reliable results.

What are the key skills and qualifications needed to thrive as a cell based potency assay scientist, and why are they important?

To excel as a Cell Based Potency Assay Scientist, you need a solid background in cellular biology, assay development, and quantitative analysis, usually supported by a degree in life sciences or a related field. Familiarity with laboratory instruments like flow cytometers, plate readers, and proficiency in data analysis software such as GraphPad Prism are typically required, along with knowledge of GMP/GLP standards. Attention to detail, strong problem-solving abilities, and effective communication skills are essential soft skills in this role. These competencies ensure accurate assay results, regulatory compliance, and clear collaboration with cross-functional teams in biopharmaceutical development.

What is the difference between Cell Based Potency Assay vs Cell Culture Technician?

AspectCell Based Potency AssayCell Culture Technician
Primary ResponsibilitiesAssessing the biological activity of products using cell-based methodsMaintaining and preparing cell cultures for various experiments
Required SkillsKnowledge of assay development, data analysis, cell biology techniquesCell culture techniques, aseptic handling, media preparation
Work EnvironmentLaboratories focused on assay validation and quality controlCell culture labs, manufacturing, or research facilities
Common CertificationsBiotech or laboratory certifications, cell biology trainingCell culture training, laboratory safety certifications

While both roles involve working with cells, the Cell Based Potency Assay specialist focuses on developing and performing assays to measure product activity, whereas the Cell Culture Technician primarily prepares and maintains cell cultures. The assay role requires analytical skills and assay-specific knowledge, while the technician role emphasizes cell handling and maintenance skills.

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Cell Based Potency Assay jobs near you
Infographic showing various Cell Based Potency Assay job openings in the United States as of August 2026, with employment types broken down into 1% As Needed, 78% Full Time, 14% Part Time, and 7% Contract. Highlights an 86% Physical, 2% Hybrid, and 12% Remote job distribution.

Senior Scientist I, Quality Control

Candel Therapeutics

Needham, MA • On-site

$155K - $160K/yr

Full-time

Re-posted 29 days ago

Job description


Salary $155K - $160K 
On site role in Needham
Senior Scientist I, Quality Control is responsible for executing highly complex analytical assays supporting clinical and commercial programs. This position collaborates with external manufacturing and tech transfer and is focused on Adenovirus and Herpesvirus vectors, associated cell-based potency assays, as well as performing training of new technical staff and troubleshooting and validation of new and established assays. The Senior Scientist I, Quality Control works with various cell lines, performs analytical methods, trends quality attributes, and suitability of product lines for continued use. 

Essential Areas of Responsibility: 

  • Participate in the development of cell culture and viral vector production using Adenovirus and Herpesvirus production systems. 

  • Function as subject matter expert (SME) for technical platforms and new methodologies. 

  • Perform assays in support of process development including cell-based assays, ELISA, HPLC, qPCR, SDS-PAGE, UV-spectroscopy. 

  • Generate, manage, evaluate, and maintain critical data in a highly organized manner and document in paper or Electronic Laboratory notebook. 

  • Participate in the development, optimization, and validation of new assays. 

  • Assist with the development of SOPs and batch records for use in Quality Control, or external CMOs. 

  • Interact with other departments such as Analytical development, Quality Assurance, Regulatory Affairs, Research, Upstream and Downstream Process Development. 

  • Contribute to laboratory support duties associated with operating a QC laboratory. 

  • Guide, direct, and train direct reports and team members, including performance monitoring, constructive feedback, quality standards, etc. 

  • Able to react to change productively and handle other essential tasks as assigned. 

Minimum Education, Experience and Skill Requirements: 

Education: 

  • PhD or equivalent in biology, chemistry, biochemistry, or related field plus applicable experience. (Internship and/or post-doctoral experience is also accepted) 

Experience: 

  • Hands-on experience with aseptic techniques related to mammalian cell culture (Vero and HEK293 cells lines) 

  • Hands-on experience in laboratory techniques supporting virus, protein and DNA analysis: SDS-PAGE, Western Blot, BCA, residual DNA, HPLC, ELISA. 

  • Willingness to learn (new methods, drug development processes, new modalities, etc.) and ability to demonstrate scientific curiosity and innovation. 

  • Previous experience in small biotech/pharma company.  

  • Previous experience working with viruses.  

  • Ability to work independently.  

  • Familiarity with basic regulatory expectations around product control strategies and the ICH guidelines for method qualification.  

  • Familiarity with Drug Substance and Drug Product release and stability testing programs.  

  • A strong background in one or more analytical techniques such as various HPLC based methods, microplate UV/Vis/Luminescent assays, cell-based assays including virus quantification and potency, qPCR, electrophoresis, sizing techniques such as DLS, etc.  

  • Ability to write technical documents, including but not limited to method SOPs, development reports, qualification reports, method transfer protocols and method transfer report.  

  • Functional understanding of GxP principles.  

  • Strong computer skills and good verbal and written communication skills.  

  • Very good collaboration and team building skills. 

Must be authorized to work in the US. No sponsorships available.
We are not accepting resumes from agencies at this time. 

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