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Cell Based Potency Assay Jobs in Seattle, WA (NOW HIRING)

Fred Hutch

Quality Control Analyst III/IV

Seattle, WA · On-site

$27.25 - $36.75/hr

Cross training in other cell-based potency, biologics, and microbial assays will be required. Responsibilities * Lead technical support, root-cause analysis, and troubleshooting for flow cytometry ...

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Cell Based Potency Assay information

What are cell based potency assays?

Cell based potency assays are laboratory tests that use living cells to measure the biological activity of a drug, vaccine, or biologic product. These assays help determine how effective a compound is in producing a desired cellular response, making them crucial for drug development and quality control. By closely mimicking the drug’s mechanism of action in the body, they provide more relevant information about efficacy and safety compared to non-cellular assays.

What are some common challenges faced when developing and validating cell based potency assays in a laboratory setting?

Developing and validating cell-based potency assays can be challenging due to the inherent biological variability of living cells, which can impact assay reproducibility and consistency. Additionally, optimizing assay conditions—such as cell passage number, incubation times, and reagent quality—requires careful attention to detail. Collaboration across multidisciplinary teams, including scientists, quality control, and regulatory affairs, is often necessary to ensure the assay meets rigorous industry and compliance standards. Successful candidates should be comfortable troubleshooting technical issues and adapting protocols to achieve reliable results.

What are the key skills and qualifications needed to thrive as a cell based potency assay scientist, and why are they important?

To excel as a Cell Based Potency Assay Scientist, you need a solid background in cellular biology, assay development, and quantitative analysis, usually supported by a degree in life sciences or a related field. Familiarity with laboratory instruments like flow cytometers, plate readers, and proficiency in data analysis software such as GraphPad Prism are typically required, along with knowledge of GMP/GLP standards. Attention to detail, strong problem-solving abilities, and effective communication skills are essential soft skills in this role. These competencies ensure accurate assay results, regulatory compliance, and clear collaboration with cross-functional teams in biopharmaceutical development.

What is the difference between Cell Based Potency Assay vs Cell Culture Technician?

AspectCell Based Potency AssayCell Culture Technician
Primary ResponsibilitiesAssessing the biological activity of products using cell-based methodsMaintaining and preparing cell cultures for various experiments
Required SkillsKnowledge of assay development, data analysis, cell biology techniquesCell culture techniques, aseptic handling, media preparation
Work EnvironmentLaboratories focused on assay validation and quality controlCell culture labs, manufacturing, or research facilities
Common CertificationsBiotech or laboratory certifications, cell biology trainingCell culture training, laboratory safety certifications

While both roles involve working with cells, the Cell Based Potency Assay specialist focuses on developing and performing assays to measure product activity, whereas the Cell Culture Technician primarily prepares and maintains cell cultures. The assay role requires analytical skills and assay-specific knowledge, while the technician role emphasizes cell handling and maintenance skills.

What are popular job titles related to Cell Based Potency Assay jobs in Seattle, WA?

For Cell Based Potency Assay jobs in Seattle, WA, the most frequently searched job titles are:

What job categories do people searching Cell Based Potency Assay jobs in Seattle, WA look for?

The top searched job categories for Cell Based Potency Assay jobs in Seattle, WA are:

What cities near Seattle, WA are hiring for Cell Based Potency Assay jobs?

Cities near Seattle, WA with the most Cell Based Potency Assay job openings:

Cell Based Potency Assay jobs near you
Infographic showing various Cell Based Potency Assay job openings in Seattle, WA as of August 2026, with employment types broken down into 78% Full Time, and 22% Contract. Highlights an 89% In-person, and 11% Remote job distribution.

Senior Scientist I, Functional Biocharacterization & Impurities

Scorpion Therapeutics

Redmond, WA • On-site

$150 - $210/hr

Other

Posted 5 days ago

Job description

Responsibilities:
  • Serve as a subject matter expert in development of cell-based assay formats for early and late phase biologics programs.
  • Lead a team to implement method development and phase-appropriate validation for cell-based assays across formats.
  • Supervise and develop direct reports; mentor and train junior staff.
  • Transfer methods to Quality Control laboratory.
  • Author technical documents.
  • Participate in process development teams (potentially as potency lead and analytical team lead).
  • Execute comparability and biosimilarity assessments.
  • Lead technology development to improve throughput, efficiency, and onboard new technologies.
  • Author and contribute to regulatory filing documents (IND, INDa, BLA, IMPD).
  • Present data to internal teams, clients, conferences, and peer-reviewed journals.
  • Lead cross-functional teams and initiatives.
Required Qualifications:
  • PhD (3+ years), MS (5+ years), or BS (10+ years) in Biochemistry, Molecular/Cellular Biology, Chemical Engineering, Bioengineering, Chemistry, or related.
  • Understanding of ICH/USP guidelines for analytical and potency assay development/validation.
  • Experience in development and phase-appropriate validation of potency and methods.
  • Experience managing and mentoring direct reports.
  • Strong understanding of link between Mechanism of Action and analytical method development; effects of impurities on biological manufacturing.
  • Technology development experience relevant to potency assays (e.g., FcgR effector function assays, large-scale cell banking, image/flow cytometry).
  • Strong oral and written communication; ability to thrive in fast-paced, collaborative environments.
Preferred Qualifications:
  • Experience with SoftMax Pro, JMP, and Microsoft Office.
  • Experience with late-stage regulatory filings.
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