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Car T Scientist Jobs (NOW HIRING)

Jj

Senior Scientist, In-vivo CAR-T

Spring House, PA · On-site

$87K - $119K/yr

We are searching for the best talent for a Senior Scientist, In-vivo CAR-T, to be based on-site in Spring House, PA. Purpose: The Senior Scientist will support the development, optimization, and ...

Jj

Principal Scientist, In-vivo CAR-T

Malvern, PA · On-site

We are searching for the best talent for a Principal Scientist, In-vivo CAR-T, to be based on-site in Malvern, PA. Purpose: The Principal Scientist will support the development, optimization, and ...

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Car T Scientist information

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$42.5K

$94.4K

$153K

How much do car t scientist jobs pay per year?

As of Aug 19, 2026, the average yearly pay for car t scientist in the United States is $94,420.00, according to ZipRecruiter salary data. Most workers in this role earn between $59,000.00 and $119,000.00 per year, depending on experience, location, and employer.

What does a Car T Scientist do?

A CAR T Scientist researches and develops chimeric antigen receptor (CAR) T-cell therapies, a type of immunotherapy used to treat cancer. They design, test, and optimize CAR T cells in laboratory settings, ensuring their safety and effectiveness before clinical trials. Their work involves genetic engineering, cell culture, and analyzing immune responses. CAR T Scientists collaborate with teams of biologists, clinicians, and regulatory experts to advance therapies from the lab to patient treatment.

What are the key skills and qualifications needed to thrive as a Car T Scientist?

To thrive as a Car T Scientist, you need a strong background in cellular biology, immunology, and molecular techniques, typically supported by an advanced degree in a relevant scientific field. Familiarity with laboratory equipment such as flow cytometers, cell culture systems, and gene-editing technologies like CRISPR, as well as compliance with biosafety and Good Laboratory Practice (GLP) standards, is essential. Strong problem-solving skills, effective communication, and attention to detail are important soft skills in this position. These competencies are crucial for conducting research and development of CAR T-cell therapies safely and efficiently while collaborating within multidisciplinary teams.

What does a typical workday look like for a Car T Scientist?

A typical workday for a Car T Scientist involves planning and performing laboratory experiments related to the development and optimization of CAR T-cell therapies, such as designing constructs, culturing cells, and analyzing results using advanced techniques like flow cytometry. You'll also document findings, contribute to troubleshooting sessions, and participate in team meetings to strategize ongoing projects or share data. Collaboration is common, as you'll work closely with colleagues in research, clinical, and manufacturing teams. The role offers a dynamic environment with hands-on lab work, opportunities for scientific discussion, and the chance to make meaningful impacts in advancing cell therapy.

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Car T Scientist jobs near you
Infographic showing various Car T Scientist job openings in the United States as of August 2026, with employment types broken down into 37% Full Time, 59% Part Time, and 4% Contract. Highlights an 99% Physical, and 1% Remote job distribution, with an average salary of $94,420 per year, or $45.4 per hour.

Scientist, Solid Tumor CAR-T

Legend Biotech US

Philadelphia, PA • On-site

Full-time

Posted 27 days ago

Job description

Legend Biotech is seeking a Scientist, Solid Tumor CAR-T as part of the Research and Development team based in Philadelphia, PA. 

Role Overview

We are seeking a highly motivated Scientist to join our interdisciplinary cell therapy team at Legend Biotech, focused on advancing CAR-T cell therapies for solid tumors. This role is central to our in vivo CAR-T platform and will drive preclinical development from construct design through animal model efficacy studies.

The ideal candidate holds a PhD in Immunology, Immuno-Oncology, or a closely related discipline, with up to 3 years of postdoctoral experience. You are a rigorous scientist who thrives in a fast-paced, collaborative environment and is passionate about translating basic immunology insights into transformative oncology therapies.

Key Responsibilities

  • Design and execute in vitro CAR-T functional assays.
  • Perform comprehensive phenotypic analysis of T cell differentiation, activation, and memory subsets.
  • Evaluate CAR-T cell trafficking and tumor infiltration in vivo using flow cytometry and immunohistochemistry.
  • Handling and engineering human and murine T cells as well as various cancer cells.
  • Engineering and maintaining various cancer cell lines for model development.
  • Analyze and interpret data, troubleshooting, maintain detailed experimental records. 

Requirements

  • A scientist in Immunology, Immuno-Oncology, Tumor Immunology, Cancer Biology, or a closely related field.
  • Candidates completing ther PhD within the past 3 years are strongly encouraged to apply.
  • Primary human T cell isolation, activation, lentiviral transduction, and expansion is required.
  • Multicolor flow cytometry: panel design, data acquisition (e.g., Attune,Novocyte, Cytek Aurora), and analysis (FlowJo).
  • Standard molecular biology: PCR/qPCR, lentiviral vector packaging and titration, Western blot.
  • Experience with humanized mouse models for in vivo CAR-T evaluation.
  • Proficiency in CAR-T cell trafficking studies: IHC/IF of tumor sections, in vivo imaging.
  • Familiarity with gene editing tools (CRISPR/Cas9) for cell engineering.
  • Experience with in vitro Organoid cancer model establishment and expansion.
  • Experience in solid tumor indications (e.g., lung, gastric, or other refractory cancers).
  • Contributions to innovation in cell therapy (publications, patents, or conference presentations).

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