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Entry Level Car T Scientist Jobs (NOW HIRING)

Legend Biotech USA, Inc.

$110K - $145K/yr

Legend Biotech is seeking a Scientist, Solid Tumor CAR-T as part of the Research and Development team based in Philadelphia, PA. Role OverviewWe are seeking a highly motivated Scientist to join our ...

Legend Biotech USA, Inc.

$110K - $145K/yr

Legend Biotech is seeking a Scientist, Solid Tumor CAR-T as part of the Research and Development team based in Philadelphia, PA. Role OverviewWe are seeking a highly motivated Scientist to join our ...

Legend Biotech USA, Inc.

$96K - $126K/yr

Legend Biotech is seeking a Scientist, In Vivo CAR-T Pipeline as part of the Research and Development team based in Philadelphia, PA.Role OverviewLegend Biotech is a global leader in the development ...

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Entry Level Car T Scientist information

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How much do entry level car t scientist jobs pay per year?

As of Sep 13, 2026, the average yearly pay for entry level car t scientist in the United States is $111,343.00, according to ZipRecruiter salary data. Most workers in this role earn between $94,500.00 and $137,000.00 per year, depending on experience, location, and employer.

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Entry Level Car T Scientist jobs near you
Infographic showing various Entry Level Car T Scientist job openings in the United States as of August 2026, with employment types broken down into 35% Full Time, 60% Part Time, and 5% Contract. Highlights an 99% Physical, and 1% Remote job distribution, with an average salary of $111,343 per year, or $53.5 per hour.

Scientist, Solid Tumor CAR-T

Philadelphia, PA

Legend Biotech US
Biotechnology Research and Development • 1 - 5K employees
Learn more about Legend Biotech USexternal

Full-time

Re-posted 22 days ago

Legend Biotech rating

9.2

Company rating: 9.2 out of 10

Based on 6 frontline employees who took The Breakroom Quiz

Job description

Legend Biotech is seeking a Scientist, Solid Tumor CAR-T as part of the Research and Development team based in Philadelphia, PA. 

Role Overview

We are seeking a highly motivated Scientist to join our interdisciplinary cell therapy team at Legend Biotech, focused on advancing CAR-T cell therapies for solid tumors. This role is central to our in vivo CAR-T platform and will drive preclinical development from construct design through animal model efficacy studies.

The ideal candidate holds a PhD in Immunology, Immuno-Oncology, or a closely related discipline, with up to 3 years of postdoctoral experience. You are a rigorous scientist who thrives in a fast-paced, collaborative environment and is passionate about translating basic immunology insights into transformative oncology therapies.

Key Responsibilities

  • Design and execute in vitro CAR-T functional assays.
  • Perform comprehensive phenotypic analysis of T cell differentiation, activation, and memory subsets.
  • Evaluate CAR-T cell trafficking and tumor infiltration in vivo using flow cytometry and immunohistochemistry.
  • Handling and engineering human and murine T cells as well as various cancer cells.
  • Engineering and maintaining various cancer cell lines for model development.
  • Analyze and interpret data, troubleshooting, maintain detailed experimental records. 

Requirements

  • A scientist in Immunology, Immuno-Oncology, Tumor Immunology, Cancer Biology, or a closely related field.
  • Candidates completing ther PhD within the past 3 years are strongly encouraged to apply.
  • Primary human T cell isolation, activation, lentiviral transduction, and expansion is required.
  • Multicolor flow cytometry: panel design, data acquisition (e.g., Attune,Novocyte, Cytek Aurora), and analysis (FlowJo).
  • Standard molecular biology: PCR/qPCR, lentiviral vector packaging and titration, Western blot.
  • Experience with humanized mouse models for in vivo CAR-T evaluation.
  • Proficiency in CAR-T cell trafficking studies: IHC/IF of tumor sections, in vivo imaging.
  • Familiarity with gene editing tools (CRISPR/Cas9) for cell engineering.
  • Experience with in vitro Organoid cancer model establishment and expansion.
  • Experience in solid tumor indications (e.g., lung, gastric, or other refractory cancers).
  • Contributions to innovation in cell therapy (publications, patents, or conference presentations).

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