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Bioconjugation Scientist Jobs (NOW HIRING)

Thermo Fisher Scientific

R&D Scientist III

Fremont, CA

$100K - $133K/yr

... Scientific team, you'll discover meaningful work that makes a positive impact on a global scale ... Apply your hands-on expertise in organic synthesis, bioconjugation, and analytical chemistry to ...

Cellanome

Staff Scientist, Chemistry

Foster City, CA · On-site

$140K - $200K/yr

Develop novel chemistries or bioconjugation strategies for Cellanome's consumable product line. * Develop strategies for immobilization or encapsulation of key reagents on surfaces or in particles.

Waters Corporation

Sr Scientist

Milford, MA · Hybrid

$100K - $137K/yr

Experience with different solid surface bioconjugation approaches and the quantification of ... WAT) is a global leader in life sciences and diagnostics, dedicated to accelerating the benefits of ...

Thermo Fisher Scientific

R&D Scientist III

Fremont, CA · On-site

$100K - $133K/yr

... Scientific team, you'll discover meaningful work that makes a positive impact on a global scale ... Apply your hands-on expertise in organic synthesis, bioconjugation, and analytical chemistry to ...

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Bioconjugation Scientist information

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How much do bioconjugation scientist jobs pay per year?

As of Jun 15, 2026, the average yearly pay for bioconjugation scientist in the United States is $112,400.00, according to ZipRecruiter salary data. Most workers in this role earn between $105,000.00 and $120,500.00 per year, depending on experience, location, and employer.

What are the typical daily responsibilities of a Bioconjugation Scientist?

A Bioconjugation Scientist typically spends their day designing and performing experiments to create and characterize conjugates of biomolecules, such as antibodies, proteins, or nucleic acids, with various chemical tags or drugs. Routine responsibilities include preparing reagents, optimizing reaction conditions, running purification and analytical assays, and documenting results in laboratory notebooks or electronic systems. Collaboration with cross-functional teams—such as analytical chemistry, biology, or process development—is frequent to ensure projects move efficiently from research to development stages. This role often requires meticulous attention to experimental detail, the ability to manage multiple projects simultaneously, and strong data interpretation skills. Regular team meetings and presentations are also common aspects of the work environment.

What is a Bioconjugation Scientist job?

A Bioconjugation Scientist specializes in developing and optimizing techniques to attach biomolecules, such as proteins, peptides, or antibodies, to other molecules like drugs, fluorophores, or nanoparticles. This work is critical in biopharmaceuticals, diagnostics, and drug delivery systems. They design and perform chemical or enzymatic conjugation reactions, analyze conjugates for stability and functionality, and troubleshoot process challenges. Additionally, they collaborate with cross-functional teams to improve bioconjugation strategies for therapeutic and diagnostic applications.

What are the key skills and qualifications needed to thrive in the Bioconjugation Scientist position, and why are they important?

To thrive as a Bioconjugation Scientist, you need a strong background in chemistry, biochemistry, or related life sciences, with hands-on experience in protein modification, organic synthesis, and analytical techniques. Familiarity with tools such as HPLC, mass spectrometry, and relevant software for data analysis is common, along with knowledge of GLP/GMP practices. Strong problem-solving skills, attention to detail, and clear communication are vital soft skills for collaborating on interdisciplinary research projects. These capabilities enable precise and efficient development of bioconjugated molecules for applications in diagnostics, therapeutics, and biotechnology.

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Bioconjugation Scientist jobs near you
Infographic showing various Bioconjugation Scientist job openings in the United States as of June 2026, with employment types broken down into 100% Full Time. Highlights an 78% In-person, and 22% Remote job distribution, with an average salary of $112,400 per year, or $54 per hour.
Associate Scientist, Oligonucleotide Chemistry & Delivery

Associate Scientist, Oligonucleotide Chemistry & Delivery

Denali Therapeutics

South San Francisco, CA • On-site

$106K - $138K/yr

Full-time

Medical, Retirement

Posted 9 days ago

Job description

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients.
We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients.
This role will apply oligonucleotide chemistry and bioconjugation expertise to advance novel therapeutics within our Oligonucleotide Transport Vehicle (OTV) platform. This is an exciting and unique opportunity to contribute to several programs and position us for the future as our groundbreaking OTV therapeutics enter the clinical phase.
Key Accountabilities/Core Job Responsibilities:
  • Design, synthesize, purify, and characterize oligonucleotide therapeutics, including siRNA/ASOs, in support of early discovery OTV programs.
  • Design and generate antibody-oligonucleotide conjugates to support targeted delivery of siRNA/ASOs using established and emerging bioconjugation technologies.
  • Support high-throughput and mid-scale oligonucleotide synthesis activities, including the evaluation of novel chemistries, modifications, and workflow innovations to enable rapid discovery-stage generation of siRNA/ASOs and bioconjugates within one or more preclinical drug discovery programs.
  • Develop, refine, and troubleshoot oligonucleotide synthesis, bioconjugation, purification, and analytical methods in support of new biotherapeutic designs.
  • Apply analytical technologies, including UV-Vis spectrophotometry, high-performance liquid chromatography (HPLC), mass spectrometry (MS), multi-angle light scattering (MALS), and other orthogonal characterization techniques, to analyze, purify, quantify, and characterize oligonucleotides and bioconjugates.
  • Interpret in vitro and in vivo experimental data to generate structure-activity relationships (SAR) informing iterative experiment design and ultimately advancing preclinical candidate nomination.
  • Collaborate closely with cross-functional partners across Biology, Protein Sciences, Drug Metabolism and Pharmacokinetics (DMPK), and related functions to advance drug discovery objectives and support program progression.
  • Maintain accurate, complete, and timely documentation of experimental data in electronic laboratory notebooks.
  • Communicate scientific results, technical insights, and recommendations clearly in team meetings and cross-functional discussions.
  • Contribute to a collaborative, innovative, and scientifically rigorous research environment.

Qualifications/Skills:
  • Typically requires a minimum of 2+ years of related experience with a Bachelor's degree; or 1+ years and a Master's degree
  • Strong hands-on experience in oligonucleotide synthesis, purification, and characterization, including siRNA/ASOs.
  • Experience with bioconjugation chemistry and analytical characterization of oligonucleotide conjugates.
  • Demonstrated ability to develop and troubleshoot experimental workflows and to independently design, execute, and interpret experiments in a discovery research setting.
  • Excellent written and verbal communication skills, with the ability to work effectively in a collaborative, multidisciplinary team.

Salary Range: $106,000.00 to $138,000.00 . Compensation for the role will depend on a number of factors, including a candidate's qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at https://www.denalitherapeutics.com/careers
This compensation and benefits information is based on Denali's good faith estimate as of the date of publication and may be modified in the future.
Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class.

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