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Bioconjugation Principal Scientist Jobs (NOW HIRING)

Quanterix

Sr Principal Scientist

Billerica, MA · On-site

$170K - $200K/yr

We are seeking an innovative and highly accomplished Senior Principal Scientist to lead the ... Develop and optimize bioconjugation strategies involving antibodies, proteins, oligonucleotides ...

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Amgen Inc. (IR)

Career Category Scientific Process Development Senior Principal Scientist Bioconjugates Join Amgen ... Drive bioconjugation technology innovation * Support cGMP manufacturing and technology transfer to ...

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Dyne Tx

... proprietary bioconjugation platform. The Principal Scientist of Oligonucleotide Development will steer the development of preclinical assets and help define CMC strategies within a matrixed ...

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Bioconjugation Principal Scientist information

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$68.5K

$144K

$190.5K

How much do bioconjugation principal scientist jobs pay per year?

As of Sep 12, 2026, the average yearly pay for bioconjugation principal scientist in the United States is $144,009.00, according to ZipRecruiter salary data. Most workers in this role earn between $117,500.00 and $169,000.00 per year, depending on experience, location, and employer.

What does a bioconjugation principal scientist do?

A Bioconjugation Principal Scientist is responsible for leading research and development projects that involve chemically linking biomolecules, such as proteins, antibodies, or nucleic acids, to other molecules or drugs. Their work is crucial in the creation of targeted therapies, diagnostics, and drug delivery systems. They design experiments, analyze data, oversee laboratory teams, and collaborate with cross-functional groups to advance bioconjugation strategies and products. Additionally, they ensure compliance with regulatory standards and contribute to scientific publications and patent applications.

What are the key skills and qualifications needed to thrive as a bioconjugation principal scientist?

To thrive as a Bioconjugation Principal Scientist, you need a strong background in chemistry, biochemistry, or related fields, typically supported by a Ph.D. and experience in bioconjugation techniques. Expertise with analytical tools such as HPLC, mass spectrometry, and bioconjugation-specific methodologies, along with knowledge of regulatory standards, is essential. Strong problem-solving, leadership, and communication skills help manage cross-functional teams and effectively drive projects forward. These skills ensure the successful development of complex biologic therapeutics and maintain high standards of scientific rigor and collaboration.

What are some common challenges faced by a bioconjugation principal scientist when developing new therapeutic molecules?

A Bioconjugation Principal Scientist often faces challenges related to optimizing the efficiency and specificity of conjugation processes, such as ensuring site-selectivity and maintaining biomolecule stability. Balancing the desired therapeutic effects while minimizing off-target activities can be complex, requiring in-depth knowledge of both chemistry and biology. Additionally, scaling up from lab experiments to manufacturing while adhering to regulatory standards adds another layer of complexity. Close collaboration with analytical, formulation, and process development teams is essential to address these challenges and drive successful project outcomes.

What is the difference between Bioconjugation Principal Scientist vs Bioconjugation Scientist?

AspectBioconjugation Principal ScientistBioconjugation Scientist
CredentialsAdvanced degree (PhD or equivalent), extensive experienceMaster's or PhD, relevant industry experience
Work EnvironmentLeadership roles, strategic planning, cross-functional collaborationHands-on laboratory research, experimental design
Industry UsageResearch & Development, senior technical rolesResearch & Development, technical contributor roles

The main difference between a Bioconjugation Principal Scientist and a Bioconjugation Scientist lies in their level of responsibility and experience. The Principal Scientist typically leads projects, develops strategies, and provides expert guidance, while the Scientist focuses on executing experiments and supporting research efforts. Both roles require strong technical skills, but the Principal Scientist often has more leadership duties and a broader scope of influence within the organization.

What are popular job titles related to Bioconjugation Principal Scientist jobs?

For Bioconjugation Principal Scientist jobs, the most frequently searched job titles are:

Infographic showing various Bioconjugation Principal Scientist job openings in the United States as of September 2026, with employment types broken down into 90% Full Time, 8% Part Time, 1% Temporary, and 1% Contract. Highlights an 91% Physical, 3% Hybrid, and 6% Remote job distribution, with an average salary of $144,009 per year, or $69.2 per hour.

Sr Principal Scientist

Billerica, MA • On-site

Quanterix
Biotechnology Research and Development • 201 - 500 employees
Learn more about Quanterixexternal

$170K - $200K/yr

Full-time

Medical, Dental, Vision, Retirement, PTO

Posted 2 days ago

New

Job description

Senior Principal ScientistBillerica, MA
Quanterix is a global leader in ultra-sensitive biomarker detection, enabling breakthroughs in disease research, diagnostics, and drug development. Its vision is to lead the next era of precision biomarker science to power earlier detection, better decisions, and improved human health. Its mission is to make biology measurable at its most fundamental level, delivering earlier insight when it matters most. Across discovery to clinical applications, Quanterix empowers scientists and healthcare providers to improve patients’ lives through detection and understanding of disease. Its proprietary Simoa® technology delivers industry-leading sensitivity, allowing researchers to detect and quantify biomarkers in blood and other fluids at concentrations far below traditional limits. With more than 3,400 peer-reviewed publications, Quanterix has been a trusted partner to the scientific community for nearly two decades. In 2025, Quanterix acquired Akoya Biosciences, The Spatial Biology Company®, adding multiplexed tissue imaging with single-cell resolution to its portfolio. Together, the combined company offers a uniquely integrated platform that connects biology across blood and tissue—advancing precision medicine from discovery to diagnostics.
ROLE SUMMARY:
We are seeking an innovative and highly accomplished Senior Principal Scientist to lead the development of next-generation assay reagents and detection technologies supporting advanced biomarker analysis platforms. This role will serve as a technical leader in the design, optimization, and commercialization of novel reagents and assay systems, with a primary focus on spatial dyes, bead technologies, and bioconjugation chemistry.
The successful candidate will combine deep scientific expertise in assay development, molecular detection technologies, and conjugation chemistry with demonstrated leadership in cross-functional product development environments. This position will drive innovation from concept through commercialization and play a critical role in expanding platform capabilities for highly sensitive multiplexed protein and biomarker detection.
WHAT YOU’LL DO:
Scientific Leadership
  • Serve as the subject matter expert for spatial dye technologies, bead-based assays, and conjugation chemistry across the organization.
  • Define scientific strategy and technology roadmaps for next-generation assay reagents and detection systems.
  • Lead innovation efforts focused on improving assay sensitivity, specificity, multiplexing capability, and performance.
  • Provide scientific leadership for complex technical investigations and root-cause analyses.
Spatial Dye Innovation
  • Lead research and development of novel spatial dye architectures and labeling approaches.
  • Investigate fluorophore chemistry, signal amplification strategies, and spatially encoded detection systems.
  • Develop solutions to improve multiplexing performance, signal discrimination, and assay robustness.
  • Drive intellectual property generation in dye chemistry and spatial detection technologies.
Bead Technology Development
  • Lead development and optimization of functionalized bead systems utilized in digital immunoassays and multiplex detection platforms.
  • Develop novel bead surface chemistries and reagent architectures to enhance assay performance.
  • Evaluate new bead materials, manufacturing methods, and coating strategies.
  • Collaborate with manufacturing teams to ensure scalability and reproducibility of bead production processes.
Conjugation Chemistry
  • Develop and optimize bioconjugation strategies involving antibodies, proteins, oligonucleotides, fluorophores, enzymes, and nanoparticles.
  • Design and characterize dye-antibody, bead-antibody, and other biomolecular conjugates.
  • Apply advanced analytical techniques to evaluate conjugate quality, stability, functionality, and performance.
  • Establish best practices for conjugation process development, scale-up, and quality control.
BASIC QUALIFICATIONS:
  • Ph.D. in Chemistry, Biochemistry, Molecular Biology, Bioengineering, Analytical Chemistry, Immunology, or related scientific discipline.
  • 20+ years of industry experience in assay development, reagent development, or diagnostic product development.
PREFERRED QUALIFICATIONS:
  • Demonstrated expertise in biomarker detection technologies, including ultra-sensitive immunoassays, spatial biomarker applications, bead-based systems, and biomolecular conjugation chemistry.
  • Proven track record translating scientific innovation into commercial products.
  • Experience supporting regulated diagnostic products, including IVD, CLIA, or FDA-regulated environments.
  • Inventor on patents related to assay technologies, bioconjugation chemistry, dyes, or biomarker detection systems.
  • Publication record in high-impact scientific journals.
  • Experience scaling reagent, assay, or bead manufacturing processes.
  • Expertise in multiplex protein detection and spatial biology applications.
EXPECTATIONS, COMPETENCIES, SKILLS amp; ABILITIES:
  • Onsite role based at 900 Middlesex Turnpike, Billerica, MA.
  • Travel up to 10–20% as needed for collaborations, conferences, and partner engagements.
  • Recognized scientific thought leader who demonstrates sound judgment, intellectual curiosity, and the ability to solve complex, ambiguous technical problems.
  • Ability to influence technical direction across matrixed teams through clear scientific rationale, data-driven recommendations, and collaborative decision-making.
  • Strong experimental design, data interpretation, troubleshooting, and statistical analysis skills with the ability to translate findings into practical product-development actions.
  • Excellent written, verbal, and presentation skills, including the ability to communicate complex scientific concepts to technical, executive, commercial, and cross-functional audiences.
  • Demonstrated ability to mentor scientists, foster technical rigor, and promote a culture of scientific excellence, accountability, collaboration, and continuous improvement.
  • Comfortable operating with a high degree of autonomy while managing priorities, risks, and deliverables in a fast-paced product development environment.
  • Ability to work effectively in laboratory and office environments; must be able to comply with applicable safety, quality, documentation, and training requirements.
WHY YOU’LL LIKE WORKING WITH US:
Our Technology:
From discovery to diagnostics, Quanterix’s ultrasensitive biomarker detection is fueling breakthroughs only made possible through its unparalleled sensitivity and flexibility. Simoa® technology has delivered the gold standard for earlier biomarker detection in blood, serum or plasma, with the ability to quantify proteins that are far lower than the Level of Quantification (LoQ). Our industry-leading precision instruments, digital immunoassay technology and CLIA-certified Accelerator laboratory have supported research that advances disease understanding and management in neurology, oncology, immunology, cardiology, and infectious disease.
Akoya Biosciences, a Quanterix company, is The Spatial Biology Company®—bringing tissue context to life through high-resolution, single-cell imaging. Akoya’s spatial phenotyping platforms help researchers visualize and measure how cells organize and interact within tissue to influence disease progression and therapeutic response. From discovery through clinical research, Akoya offers a full continuum of solutions, including PhenoCycler®, PhenoImager® Fusion and HT, and PhenoCode™ Panels. As part of Quanterix, Akoya complements a leading portfolio of ultra-sensitive biomarker detection technologies, together enabling a more complete view of biology and disease across both tissue and blood.
Our Commitment to Employees:
At Quanterix, our values are based on: Team, Innovation, Customer and Owner. Team: Challenge assumptions, not the person. Respect diversity of thought and hold ourselves to lofty standards. Innovation: Stay curious, experiment, create and change. Customer: Prioritize and celebrate these pioneers by doing our best to deliver on commitments. Owner: Act with high integrity and in the best interest of Quanterix. Take measured risks and learn from their success and failures.
We reward and recognize our employees by offering competitive compensation and a 401k plan with employer match, as well as competitive health, dental, and vision benefits for employees and their dependents. We also offer an unlimited vacation policy to all exempt employees, and a generous PTO policy for non-exempt employees. All employees are eligible for equity, employee stock purchase plan, a performance bonus, and 1:1 financial counseling/planning. We also offer Tuition Assistance. We have a free, state-of-the-art onsite fitness center for all employees. To keep you fueled up, we provide onsite employees free snacks and drinks every day!
DIVERSE amp; INCLUSIVE WORKPLACE:
Quanterix is committed to a Diverse and Inclusive workplace. We strive to recruit candidates who will bring inclusive mindsets and contribute to our values.
Quanterix is an Equal Opportunity Employer and does not discriminate based on race, national origin, gender, gender identity, sexual orientation, protected veteran status, disability, age, or other legally protected status. Quanterix will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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