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Bioconjugation Scientist Jobs (NOW HIRING)

Pharmaceutical Company

Scientist

San Diego, CA

Scientist I - Gene Therapy Nanotechnology (LNP & Bioconjugation) Location: San Diego, CA, Onsite (Monday to Friday, 9:00 AM - 5:30 PM PT) Employment Type: Contract on W2 About the Role Join a cutting ...

Cellanome

Staff Scientist, Chemistry

Foster City, CA

$140K - $200K/yr

You will be responsible for developing novel chemistries, bioconjugation methods, materials ... related scientific discipline, with a minimum of 5 years of relevant experience. * Extensive ...

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How much do bioconjugation scientist jobs pay per year?

As of Jun 15, 2026, the average yearly pay for bioconjugation scientist in the United States is $112,400.00, according to ZipRecruiter salary data. Most workers in this role earn between $105,000.00 and $120,500.00 per year, depending on experience, location, and employer.

What are the typical daily responsibilities of a Bioconjugation Scientist?

A Bioconjugation Scientist typically spends their day designing and performing experiments to create and characterize conjugates of biomolecules, such as antibodies, proteins, or nucleic acids, with various chemical tags or drugs. Routine responsibilities include preparing reagents, optimizing reaction conditions, running purification and analytical assays, and documenting results in laboratory notebooks or electronic systems. Collaboration with cross-functional teams—such as analytical chemistry, biology, or process development—is frequent to ensure projects move efficiently from research to development stages. This role often requires meticulous attention to experimental detail, the ability to manage multiple projects simultaneously, and strong data interpretation skills. Regular team meetings and presentations are also common aspects of the work environment.

What is a Bioconjugation Scientist job?

A Bioconjugation Scientist specializes in developing and optimizing techniques to attach biomolecules, such as proteins, peptides, or antibodies, to other molecules like drugs, fluorophores, or nanoparticles. This work is critical in biopharmaceuticals, diagnostics, and drug delivery systems. They design and perform chemical or enzymatic conjugation reactions, analyze conjugates for stability and functionality, and troubleshoot process challenges. Additionally, they collaborate with cross-functional teams to improve bioconjugation strategies for therapeutic and diagnostic applications.

What are the key skills and qualifications needed to thrive in the Bioconjugation Scientist position, and why are they important?

To thrive as a Bioconjugation Scientist, you need a strong background in chemistry, biochemistry, or related life sciences, with hands-on experience in protein modification, organic synthesis, and analytical techniques. Familiarity with tools such as HPLC, mass spectrometry, and relevant software for data analysis is common, along with knowledge of GLP/GMP practices. Strong problem-solving skills, attention to detail, and clear communication are vital soft skills for collaborating on interdisciplinary research projects. These capabilities enable precise and efficient development of bioconjugated molecules for applications in diagnostics, therapeutics, and biotechnology.

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Bioconjugation Scientist jobs near you
Infographic showing various Bioconjugation Scientist job openings in the United States as of June 2026, with employment types broken down into 100% Full Time. Highlights an 78% In-person, and 22% Remote job distribution, with an average salary of $112,400 per year, or $54 per hour.
Staff / Senior Scientist, Bioconjugation Chemistry

Staff / Senior Scientist, Bioconjugation Chemistry

Glyphic Biotechnologies

Berkeley, CA • On-site

$112K - $153K/yr

Full-time

Medical, Dental, Vision, Retirement, PTO

Posted 27 days ago

Job description

About Glyphic:
At Glyphic Biotechnologies, we plan to create the protein revolution for which scientists and researchers have been waiting. We are developing a massively parallel, single-molecule proteome sequencing platform that will transform life science discovery and usher in a new era of insights into human biology and disease. To date, we have raised >$80M from venture partners and non-dilutive grant funding to achieve our vision of next generation proteome sequencing.
What we are looking for in you
We are seeking a Senior or Staff Scientist, Bioconjugation to join our Chemistry team at a pivotal stage in assay development. Reporting to the Senior Director of Chemistry, you will be a hands-on expert who designs, develops, and executes bioconjugation strategies for peptide and oligonucleotide components that are central to our single-molecule proteome sequencing assay.
The ideal candidate brings deep expertise in protein and peptide bioconjugation, site-specific chemical modification of amino acid sidechains, and oligonucleotide-biomolecule conjugation, with a track record of working in complex, multi-component systems (e.g., ADCs, therapeutic bioconjugates, or new bioconjugated components for assays). A successful candidate will have an innovative method-development mindset and will effectively build new approaches to making bioconjugates. This individual will thrive in a cross-functional environment where chemical solutions must be tightly integrated into assay design.
This role offers the unique opportunity to develop first-in-class conjugation chemistry that enables single-molecule protein sequencing.
This is a full-time, exempt, in-person position with work conducted at our Berkeley, CA location.
What you'll do
Bioconjugation strategies:
  • Partner with sample prep and assay development to screen and select conjugation chemistries for peptides and oligonucleotides that enable single molecule protein sequencing
  • Design bioconjugation workflows using NHS-ester chemistry, maleimides, isothiocyanate chemistry, and click chemistry (CuAAC, SPAAC, IEDDA)
  • Prepare bioconjugation reagents to enable studies from proof-of-concept through prototype-kitting.

Peptide chemistry:
  • Develop labeling strategies based on Edman Chemistry
  • Develop and apply selective C-terminal and N-terminal conjugation chemistries
  • Develop site-specific labeling strategies for amino acid sidechains (Cys, Lys, Arg, Tyr, Trp, His, Asp/Glu) on native peptides. Screen protecting groups to enhance amino acid signal in the protein sequencing assay
  • Enable on-bead workflow to label and release peptides for interrogation in the sequencing assay

Synthesize, characterize, and scale:
  • Synthesize and purify peptide and oligonucleotide conjugates for assay testing
  • Characterize conjugation efficiency, purity, and stability using tools such as HPLC, LC-MS/MS, NMR, CE, UV/Vis, and FTIR
  • Scale conjugate synthesis from R&D quantities to prototype-grade supply for internal testing, with attention to reproducibility, shelf-life, and fit-for-purpose quality

Collaborate and document:
  • Work cross-functionally with sample preparation, assay integration, and reagent manufacturing teams to troubleshoot conjugation failures and optimize workflows
  • Contribute to intellectual property development through invention disclosures
  • Maintain rigorous experimental documentation in Confluence and laboratory notebooks; author and maintain SOPs for new conjugation methods

What you need
Required:
  • MS or PhD in organic chemistry, chemical biology, biochemistry, or a related field
  • Industry experience in bioconjugation chemistry, with demonstrated ability to independently design, develop, and troubleshoot conjugation workflows
    • MS/PhD with 8+/6+ years of experience (for Staff Scientist)
    • MS/PhD with 6+/4+ years of experience (for Senior Scientist)
  • Deep expertise in protein and/or peptide bioconjugation: NHS esters, maleimides, click chemistries (CuAAC, SPAAC, IEDDA), isothiocyanate coupling, and related bioorthogonal approaches
  • Experience with site-specific amino acid sidechain chemistry beyond maleimide chemistry (e.g. Cys, Lys, Arg, Tyr, Trp, Asp/Glu) for application in multistep workflows
  • Track record developing novel blocking groups and conducting SAR studies to optimize blocking group performance and selectivity
  • Proficiency in analytical characterization: HPLC method development, LC-MS/MS for conjugate analysis, UV/Vis, and CE
  • Method-development mindset: history of building and adapting new chemical approaches rather than executing established protocols
  • Demonstrated ability to function as an independent contributor and collaborative partner in a cross-functional team setting

Nice to have:
  • Hands-on experience with solid-phase peptide synthesis (SPPS), including protecting group strategies beyond standard Fmoc/Boc and selective on-resin modifications
  • Experience with peptide C-terminal chemistry manipulation methods: thioester formation, native chemical ligation, or photoredox/iridium-catalyzed C-terminal labeling
  • Familiarity with oligonucleotide chemistry and oligo-conjugation techniques (ITC, phosphoramidite modifications, click coupling to nucleic acids)
  • Experience with scalable surface chemistry methods for flow cells or solid-phase supports
  • Familiarity with statistical and DOE-based experimental design for chemistry optimization
  • Prior experience in an early-stage biotech or tools/diagnostics company

We're looking for a teammate that:
  • Navigates complex team dynamics, partnerships, and challenges with creativity and logic.
  • Operates with adaptability, urgency, and flexibility in evolving environments, thriving in ambiguity.
  • Drives work forward without needing to be asked, taking responsibility for outcomes rather than tasks.
  • Treats obstacles as problems to be creatively solved, not reasons something can't be done.
  • Applies sound judgment to the best available information, testing, learning, and iterating.
  • Shares early and directly when assumptions change, results are unclear, or timelines are at risk.

What you can expect from this role
Work environment:
  • Collaborative culture where your ideas and expertise are valued
  • Direct impact on product development and company direction

Professional growth:
  • Learn from a diverse team of world-class scientists and engineers
  • Contribute to first-of-their kind technologies, high-impact publications, and patents

Compensation
Estimated Base Salary $123,000 - $187,575
This is the pay range for this position that we reasonably expect to pay. Individual compensation is based on various factors including, experience, education, skillset, and geographic location. This range is for the SF Bay Area, California location and may be adjusted to the labor market in other geographic areas.
Benefits and Perks:
  • Employee Stock Option Plan
  • 100% Health Plan Coverage for Employees & Dependents (Medical, Dental, & Vision)
  • Employer Retirement Contributions to 401(k)
  • Generous Paid Time Off
  • Paid Maternity and Paternity Leave
  • Health & Wellbeing Program
  • Office Snacks and Beverages
  • Regular Team Bonding Activities

We are an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. Individuals seeking employment at Glyphic Biotechnologies are considered without regard to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation.

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